High performance liquid chromatography

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  • High Performance Liquid Chromatography

    Raju Chandra et al; A reliable and reproducible reversed-phase high performance liquid chromatography (RP-HPLC) was developed for the quantitative determination of quetiapine fumarate from marketed bulk tablets. The active ingredient of quetiapine fumarate separation achieved with C18 column using the methanol water mobile phase in the ratio of 30:70 (v/v). The active ingredient of the drug content quantify with UV detector at 359 nm. The retention time of quetiapine fumarate is 5.27 min. A good linearity relation (r2=0.999) was obtained between drug concentration and average peak areas. The limit of detection and limit of quantification of the instrument were calculated 0.02 and 0.06 μg/ml, respectively. The accuracy of the method validation…

    Words: 1867 - Pages: 8
  • High Performance Liquid Chromatography Essay

    1.5 ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY (UPLC) Since from thirty years, High performance liquid Chromatography (HPLC) is well accepted technique used in laboratories worldwide. It is one of the analytical techniques used to identify, separate and quantify each analyte in a mixture. One of the primary drivers for the development of this technique has been the progression of the packing materials (particle size, packing technology, chemistry) used to impact the separation. The fundamental…

    Words: 927 - Pages: 4
  • Liquid Chromatography Lab

    High performance liquid chromatography (HPLC) is a separation technique utilizing differences in distribution of compounds in two phases; called the stationary phase and the mobile phase. The stationary phase designates a thin layer created on the surface of fine particles and the mobile phase designates the liquid flowing over the particles. Under a certain dynamic condition, each component in a sample has a different distribution equilibrium depending upon the solubility in the phases and or…

    Words: 952 - Pages: 4
  • Acetaminophen Tablets Essay

    Introduction: Acetaminophen is a common pain reliever and fever reducer used to treat conditions such as head, muscle or tooth ache, as well as colds, fevers, and even arthritis. It is available in a tablet form to be ingested. These tablets are manufactured by a large variety of pharmaceutical manufactures including a great deal of generic brand companies. These tablets all have the same active ingredient, acetaminophen, yet each hold different inactive ingredients that can impact the overall…

    Words: 2102 - Pages: 9
  • The Principle Of Centrifugation

    Introduction: Centrifugation is a process used to separate or concentrate materials suspended in a liquid medium. It is a method used to separate molecules under the centrifugation field based on their sedimentation rate with the help of centrifugal force. It is also used to measure the physical properties of a molecule like molecular weight, density, shape, etc. If it is used for the separation of one type of materials from others is termed as preparative centrifugation and when used for…

    Words: 767 - Pages: 4
  • Summary Of Ketorolac Tromethamine

    less disintegration time. HPLC method was developed and validated for determination of content of Ketorolac Tromethamine and Phenylephrine Hydrochloride in immediate release tablet. UV spectrophotometric method was developed and validated to study drug release profile of Ketorolac Tromethamine and Phenylephrine Hydrochloride in immediate release tablet. Background: Ketorolac Tromethamine is a pyrrolizine carboxylic acid derivative structurally related to indomethacin. It is an anti inflammatory…

    Words: 854 - Pages: 4
  • Formulae Of Levodopa Floating Tablets

    CHAPTER-V FORMULATION AND EVALUATION OF LEVODOPA FLOATING TABLETS FORMULATION AND EVALUATION OF LEVODOPA FLOATING TABLETS Several approaches are currently used to retain the dosage form in the stomach. The principle of the floating tablets is simple and practically approach to achieve increased gastric residence time to obtain controlled release floating tablets designed based on the gas generating principle needs a strong floating matrix former. In this regard HPMC K4M,…

    Words: 2440 - Pages: 10
  • Glutathione Peroxidase Lab Report Antioxidant assays in gastric tissue homogenate Catalase activity Catalase activity in the gastric tissue was measured according to the procedures of Sinha (1972). One ml of homogenate solution was taken and mixed with 5 ml of phosphate buffer of pH 7.4. To this 4 ml of 0.2 M H2O2 was added and time noted. Exactly after 180 seconds of adding H2O2, a set of 1ml of reaction mixture from the above was taken and 2 ml dichromate acetic acid was added. It was then kept in a boiling…

    Words: 801 - Pages: 4
  • Research Paper Chromatography

    Introduction Chromatographic process is a separation technique which has to do with the mass transfer of test sample between a stationary and mobile phase. HPLC (High Performace Liqud Chromatography) is a vast system which involves the use of a mobile and stationary phase to separate materials. The stationary phase is usually a column packed with solids (usually silica gel) while the mobile phase is usually a solvent or a mixture of various solvents. The mobile phase usually, is the carrier of…

    Words: 2135 - Pages: 9
  • Analysis Of Cr-DLC Coatinging

    rate was much higher than that in seawater. As seen in Fig.5, the polished wear scars were obtained on the wear tracks. While the scratches appeared on the wear scar of mating balls in seawater, especially, white scratches presented on the age of wear scar in Fig.5j. That result was attributed to the calcium magnesium salt precipitation (Mg(OH)2, CaCO3), which played the role of abrasive particles on the friction interface and resulted in scratches on the wear scar of balls. On the other hand,…

    Words: 1533 - Pages: 7
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