Solubility

ABSTRACT Solubility is the phenomenon of dissolution of solid in liquid phase to give a homogenous system.Solubility is one of the important parameter to achieve desired concentration of drug in systemic circulation for pharmacological response to be shown. Poor watersolubledrugs often require high doses in order to reach therapeutic plasma concentrations after oral administration. Low aqueoussolubility is the major problem encountered with formulation development of new chemical entities. Any drug to be absorbed must be present in the form of an aqueous solution at the site of absorption. Water is the solvent of choice for liquid pharmaceuticalformulations. Mostof drugs weakly acidic and weakly basic with poor aqueous solubility. Hence various…

1) Important solubility characteristics for a solvent to be used in the crystallization of an organic solid that’s contaminated with impurities is that the organic solid should have low solubility at low temperatures in the solvent, but highly soluble at high temperatures. Also, the solvent should allow the impurities to be either completely soluble or completely insoluble at all temperatures. 2) One way to improve our percent recovery is by making a second crop of crystals by removing the…

In this lab, the main objective is to identify the identity of an unknown compound via the methods of extraction, recrystallization, and melting point determination (University of Windsor, 2015). An important factor in this experiment is solubility. Solubility is the affinity for one solvent over the other. Liquids, or aqueous solutions, that may dissolve the same compound are commonly found to be miscible. By using liquid – liquid extraction a compound can transform into an ionic form, soluble…

Introduction: Solubility is the “ability for a given substance, the solute, to dissolve in a solvent” . The effect of temperature on solubility is that when heat (energy) is added, it increases the speed on which molecules and particles move, therefore making it a quicker process. Where as with cooler temperatures there aren’t as many particles because the solvent doesn’t contain as much energy as warmer temperatures, therefore not dissolving as well as it could if it was warmer. To make jelly…

Our lab consisted of combining small amounts of aqueous solutions in order to observe their soluble nature (or lack thereof). The key concept that was involved in this lab was the concept of solubility, the ability of a substance (the solute) to dissolve in a solvent rather than to form a solid precipitate. Through this lab, we were attempting to determine the solubility of the solutions as well as observe how the solutions interact with each other -- if they form a precipitate once combined or…

RESULTS SOLUBILITY ANALYSIS: Ketoprofen sample was found to be soluble in ethanol, Chloroform, ether, acetone at neutral pH and is found to be almost insoluble in water. Solubility analysis is important because the drug has to dissolve in the solvents and also in the dissolution medium used. MELTING POINT DETERMINATION: The melting point of the Ketoprofen was found to be 96˚C by open capillary tube using microcontroller based melting point apparatus which is within the reported range of 94˚C…

The unknown compound we received consisted of white crystal-like particles and was a solid at room temperature. During the smell test, we did not receive any indication of a distinct smell, thus concluding that the compound is ionic. The solubility tests indicated that the compound was soluble in water, NaOH, and HCl and non-soluble in acetone and toluene as shown in Table 1. The compound was soluble in water indicating that the compound is either polar or ionic, but not soluble in toluene or…

II. Results and discussion: 1. Screening of ME components: 1.1. Solubility of sulpiride in ME components: In order to achieve maximum drug loading into ME formulation, the oil, which showed higher solubilization capacity for sulpiride is selected for ME preparation. The choice of oil for ME is often a compromise between its solubilization potential for the drug and its ability to microemulsify. Results in table 1 represent the solubility of sulpiride into different oils, surfactants and…

Solubility of Chemical Compounds Lab Victoria Chanderpaul Tasneem, Zarrin Ms. Rungee February 6, 2018 February 13, 2018 Reaction of Chemical Compounds When Added to Water Introduction/Purpose: The purpose of this lab was to gain an understanding of how different chemical compounds react when added to water. Hypothesis: If different pure substances are dissolved in water, then there can be an understanding of the difference between the solubility because each chemical compound have…

Solubility Curves Lab Report Objective: To demonstrate how the solubility of a salt varies with temperature and plot the solubility curve of a salt on the basis of observed data. Introduction: Solubility is the maximum amount of substance that will dissolve at a specific temperature. The units for solubility are grams of solute/ 100 grams of solvent. A solute is the substance being dissolved. A solvent is present in greater amount. The solubility of a solute is defined as the amount of…