Solubility

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  • Solubility

    ABSTRACT Solubility is the phenomenon of dissolution of solid in liquid phase to give a homogenous system.Solubility is one of the important parameter to achieve desired concentration of drug in systemic circulation for pharmacological response to be shown. Poor watersolubledrugs often require high doses in order to reach therapeutic plasma concentrations after oral administration. Low aqueoussolubility is the major problem encountered with formulation development of new chemical entities. Any drug to be absorbed must be present in the form of an aqueous solution at the site of absorption. Water is the solvent of choice for liquid pharmaceuticalformulations. Mostof drugs weakly acidic and weakly basic with poor aqueous solubility. Hence various…

    Words: 1984 - Pages: 8
  • Toluene Solubility

    1) Important solubility characteristics for a solvent to be used in the crystallization of an organic solid that’s contaminated with impurities is that the organic solid should have low solubility at low temperatures in the solvent, but highly soluble at high temperatures. Also, the solvent should allow the impurities to be either completely soluble or completely insoluble at all temperatures. 2) One way to improve our percent recovery is by making a second crop of crystals by removing the…

    Words: 777 - Pages: 4
  • Effect Of Temperature On Solubility

    Introduction: Solubility is the “ability for a given substance, the solute, to dissolve in a solvent” . The effect of temperature on solubility is that when heat (energy) is added, it increases the speed on which molecules and particles move, therefore making it a quicker process. Where as with cooler temperatures there aren’t as many particles because the solvent doesn’t contain as much energy as warmer temperatures, therefore not dissolving as well as it could if it was warmer. To make jelly…

    Words: 766 - Pages: 4
  • Solubility Lab Report

    Our lab consisted of combining small amounts of aqueous solutions in order to observe their soluble nature (or lack thereof). The key concept that was involved in this lab was the concept of solubility, the ability of a substance (the solute) to dissolve in a solvent rather than to form a solid precipitate. Through this lab, we were attempting to determine the solubility of the solutions as well as observe how the solutions interact with each other -- if they form a precipitate once combined or…

    Words: 790 - Pages: 4
  • Solubility Analysis Of Ketoprofen

    RESULTS SOLUBILITY ANALYSIS: Ketoprofen sample was found to be soluble in ethanol, Chloroform, ether, acetone at neutral pH and is found to be almost insoluble in water. Solubility analysis is important because the drug has to dissolve in the solvents and also in the dissolution medium used. MELTING POINT DETERMINATION: The melting point of the Ketoprofen was found to be 96˚C by open capillary tube using microcontroller based melting point apparatus which is within the reported range of 94˚C…

    Words: 1273 - Pages: 6
  • Solubility Of Sulpiride In Me Components

    II. Results and discussion: 1. Screening of ME components: 1.1. Solubility of sulpiride in ME components: In order to achieve maximum drug loading into ME formulation, the oil, which showed higher solubilization capacity for sulpiride is selected for ME preparation. The choice of oil for ME is often a compromise between its solubilization potential for the drug and its ability to microemulsify. Results in table 1 represent the solubility of sulpiride into different oils, surfactants and…

    Words: 1231 - Pages: 5
  • Solubility Test Lab Report

    Discussion For the first part of the experiment, a solubility test was conducted on all compounds. Because they were all ionic, every known compound naturally dissolved in water, and conducted electricity. As the next determining factor in the process to identify the unknown substance, the compounds were tested in acetone. As seen in table 2, only one compound, Ca(NO3)2 was found to be soluble in this solvent. Because the unknown solid was insoluble in acetone, Ca(NO3)2 was then eliminated as a…

    Words: 1305 - Pages: 6
  • Solubility And Bioavailability Of Ginkgo Biloba Extract

    Wang et al. (2015) formulated a solid dispersion to improve the solubility and bioavailability of Ginkgo biloba extract (GE) through hot melt technology. The polymer studied were Kollidon® VA64/Kolliphor® RH40 (85:15) and the extrusion was carried out at 120-125⁰C with 100 RPM with 25% drug load. DSC and XRD studies confirmed the amorphous conversion of the GE and the dissolution carried in 250ml of 0.1N HCl showed that the dissolution of solid dispersion of GE was significantly improved (2-3…

    Words: 876 - Pages: 4
  • Difference Between Solubility Dependent Extraction And Recrystallization

    The motivation behind this experiment was to gain insight behind the theory and practice of two laboratory techniques: solubility-dependent extraction, and recrystallization, in an effort to isolate and identify three compounds originally dissolved in a mixture. Extraction is used to isolate a specific compound. Recrystallization involves taking a crude compound and removing unwanted impurities so that a more accurate melting point can be taken, leading to a more precise identification of a…

    Words: 1249 - Pages: 5
  • Protein Solubility

    mechanistic difference between the two aspects. In the case of a pure solubility issue, i.e. a protein becomes insoluble in a certain solution (no changes in protein structure and integrity) and a solid phase is formed, a strong dilution of the system may lead to the dissolution of the protein. In such a circumstance, the term “protein associates” may more appropriately describe the formed protein solid .In this instance, protein particles are formed, especially protein aggregates and often such…

    Words: 833 - Pages: 4
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