Route of administration

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  • Pharmacokinetics Analysis

    Pharmacokinetics is the branch of pharmacology that describes how the body affects a specific drug after administration. A number of phases occur once the drug enters into contact with the gastro intestinal wall, these are described using the acronym ADME, starting with the mechanisms of absorption, which is the process by which a substance enters the blood circulation. Distribution, where the dispersion or dissemination of substances throughout the fluids and tissues of the body. ADME also include the process of metabolism, which is also known as biotransformation, it is inactivation of the xenobiotic substance.Additionally, excretion, defined as the removal of the substances from the body. Linear models assumed that the pharmacokinetic…

    Words: 894 - Pages: 4
  • Solubility

    ABSTRACT Solubility is the phenomenon of dissolution of solid in liquid phase to give a homogenous system.Solubility is one of the important parameter to achieve desired concentration of drug in systemic circulation for pharmacological response to be shown. Poor watersolubledrugs often require high doses in order to reach therapeutic plasma concentrations after oral administration. Low aqueoussolubility is the major problem encountered with formulation development of new chemical entities. Any…

    Words: 1984 - Pages: 8
  • Aloe Vegar Case Study

    intestinal tract with a reduced transit time. Also the bacterial flora appears to show benefit, with a reduction in a presence of yeasts and reduction in pH. Bowel putrefaction was decreased and protein digestion/absorption was improved. An early trial with human patients found oral administration of aloe gel effective in the treatment of peptic ulcers. The anti-ulcer activities of Aloe Vera has been attributed to several possible mechanisms including its healing effects, anti-inflammatory…

    Words: 947 - Pages: 4
  • Lornoxicam Research Paper

    a zwitterions in the strong state. The framing of two in number intramolecular N+–h•••o and N–h•••o– hydrogen bonds in a stable six-part ring geometry, S(6), renders this generally adaptable atom in an unbending adaptation (conformer A). A salt screen of LXM was attempted to enhance drug solvency and to study diverse compliances of the atom by shifting the counterion.[11] Lornoxicam • chemical Name: (3e)-6-chloro-3-[hydroxy (pyridin-2-ylamino) methylene]-2-methyl-2, 3-dihydro-4h-thieno [2,…

    Words: 864 - Pages: 4
  • Rheumatoid Arthritis Research Paper

    The aim of the present investigation is to intend, develop and evaluate a pulsatile drug delivery containing a core-in-cup based system of dry coated tablet of ketoprofen based on chronomodulated approach for management of Rheumatoid Arthritis. This pulsatile system contained a core tablet surrounded by an impermeable outer shell and top cover layer. Core tablet contained the active ingredient acting as reservoir, ethylcellulose was used to form an impermeable outer shell, the top cover layer…

    Words: 1399 - Pages: 6
  • Unit 5-Gids Case Study

    2- The fluctuations in plasma drug concentration are minimized and side effect associates with concentration are also minimized. 3- Complete absorption of drug from the floating formulation is expected even at alkaline pH of intestine. The dissolution occurs in gastric fluid and after emptying of the stomach contents the dissolved drug is available for absorption in small intestine. 4- Because of site‐specific absorption from the upper part of the GIT, Drugs that have poor bioavailability are…

    Words: 344 - Pages: 2
  • Summary Of Ketorolac Tromethamine

    The invention relates to formulation of Ketorolac Tromethamine and Phenylephrine Hydrochloride immediate release tablet having less disintegration time. HPLC method was developed and validated for determination of content of Ketorolac Tromethamine and Phenylephrine Hydrochloride in immediate release tablet. UV spectrophotometric method was developed and validated to study drug release profile of Ketorolac Tromethamine and Phenylephrine Hydrochloride in immediate release tablet. Background:…

    Words: 854 - Pages: 4
  • Advantages Of Ointments

    used in cases of localized hyperpigmentation of the skin as : Melasma (chloasma that accompany frequency of gonadal disturban). -Hyperpigmentation that follows burns. - Post inflammatory hyperpigmentations. - Hyperpigmenation that follows contact with essential oil ( Eau de cologne( and Ephelis ( Frackling) . -Hyperpigmentation following prolonged sun exposure.  Contra-indications: 1- Hypersensitivity to any of the product components. 2- Eczema or other skin conditions. 3- During…

    Words: 1013 - Pages: 5
  • Formulae Of Levodopa Floating Tablets

    CHAPTER-V FORMULATION AND EVALUATION OF LEVODOPA FLOATING TABLETS FORMULATION AND EVALUATION OF LEVODOPA FLOATING TABLETS Several approaches are currently used to retain the dosage form in the stomach. The principle of the floating tablets is simple and practically approach to achieve increased gastric residence time to obtain controlled release floating tablets designed based on the gas generating principle needs a strong floating matrix former. In this regard HPMC K4M,…

    Words: 2440 - Pages: 10
  • Essay On TPGS Concentration And Paclitaxel Solubility

    Figure 2.1.3 TPGS concentration and Paclitaxel solubility are directly related. Figure created by M. Varma, 200522. TPGS has been incorporated into various drug formulations partly because of its ability to overcome multidrug resistance (MDR). By inhibiting P-glycoprotein (P-gp) activity, the relative cytotoxicity of drugs such as doxorubicin, vinblastine, and paclitaxel was increased19. P-gp is a drug efflux pump, a.k.a. multidrug resistance protein 1 (MDR1), located in the cell membranes of…

    Words: 828 - Pages: 4
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