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Solubility Analysis Of Ketoprofen

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RESULTS
SOLUBILITY ANALYSIS:
Ketoprofen sample was found to be soluble in ethanol, Chloroform, ether, acetone at neutral pH and is found to be almost insoluble in water. Solubility analysis is important because the drug has to dissolve in the solvents and also in the dissolution medium used.
MELTING POINT DETERMINATION:
The melting point of the Ketoprofen was found to be 96˚C by open capillary tube using microcontroller based melting point apparatus which is within the reported range of 94˚C to 97˚C. It complies with the standards thus indicating the purity of the drug sample.
CALIBRATION CURVE OF KETOPROFEN:
• Calibration curve of Ketoprofen in Ethanol
Table 8: Absorbance values of ketoprofen in ethanol at 256nm
CONCENTRATION(µg/ml) ABSORBANCE …show more content…
Band Position Assignment 343534 Carboxylic acid OH group 305342 Benzene CH (sp2) 298205 Sp3 CH 169934 C=O 165305 Benzene double(=) bond 159325 Benzene double(=) bond 128271 C=O stretching

Fig 14: FTIR of pure drug + surfactant
Table 11: Band position of pure drug+ surfactant Band position Assignment 169741 C=O group 165305 Benzene double(=) bond 159133 Benzene double(=) bond 343919 OH group 293901 Sp3 CH 330031- 293901 Sp2 merged with sp3

Fig 15: FTIR of drug+ cholesterol Fig 16: FTIR of surfactant + cholesterol
EVALUATION OF NIOSOMAL DISPERSION
Particle Size and Entrapment Efficiency Analysis
Ether Injection Method
Table 12: Particle size and entrapment

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