Excipient

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  • What´s Multiparticulate Drug Delivery System?

    and is advantageous compared to conventional therapy due to the fact that Multiparticulate systems would not have to be administered at frequent times of the day. There are three ways drug can be released from multiparticulate systems, the first being diffusion out of the carrier upon contact with aqueous fluids. The second mode of release is through erosion of outer coatings which will progressively wear away at the outer layer releasing drug at a controlled rate from the bead. Thirdly osmosis can take place, where osmotic pressure builds up inside particle causing drug to be released (Dey, Majumdar and Rao, 2008). SODAS® is a technology that utilises multiparticulate drug delivery and is made up of beads containing a drug core plus any excipients that will control the release. When ingested, water soluble polymers which make up the outer layer dissolve, leaving a porous layer through which drug can diffuse out of. This system is advantageous as it allows for a range of different unique release profiles to be achieved (Gandhi and Baheti, 2013). 3. Matrix Delivery Systems Matrix delivery systems have proved to be very beneficial in oral controlled drug delivery due to the fact that they demonstrate simplicity when it comes to manufacturing, being very stable and being very reproducible (Hiremath and Saha, 2008). There are currently two systems of matrix delivery system including hydrophobic matrix tablets (Abdel-Rahman, Mahrous and El-Badry, 2009) which release drug after…

    Words: 870 - Pages: 4
  • Acetaminophen Tablets Essay

    slope of the individual data was approximately half of the group data slope (1.1634 for individual compared to 2.2576). There were no degradation products found in the HPLC results, but the area under the peak decreased at an overall consistent downward trend over the eight-week period of exposure to harsh conditions. The Publix White brand showed the most overall degradation due to the harsh conditions in which it was stored when compared across all lab sections with an R2 value of 0.54973.…

    Words: 2102 - Pages: 9
  • What Is The Selection Of Excipients Of Tamoxifen Citrate?

    4A.3 Results and discussion 4A.3.1 Selection of Excipients Drug loaded Solid Lipid Nanoparticles(D-SLN)were successfully formulated using two different lipidsand surfactants and physicochemical parameters of the same have been assessed. Tamoxifen citrate is proven adjuvant therapy of choice for postmenopausal women, primary therapy for breast cancer in elderly women as well as preventive therapy for most vulnerable women. The extensive administration of Tamoxifen citrate daily for a period of…

    Words: 1156 - Pages: 5
  • Nimodipine Research Paper

    NIMOTOP INJECTION Nimodipine 0.02% solution contains the following excipients: Ethanol 96%, Macrogol 400, sodium citrate, citric acid, Water for Injections Ph. Eur. These excipients consist of properties that aim towards the proper functionality of Nimotop. They consist of inherent stabilities that cause little or no effect in the stability of the drug and they do not have any acute or chronic toxicity. The excipients are also added into the Nimodipine 0.02% solution to enhance the biological…

    Words: 754 - Pages: 4
  • Sildenafil Citrate Research Paper

    Labotechnic for about 20 minutes. The proposed formulation may then be compressed using a Bonals continuous eccentric press. The tablet is then formed [Joseph M.]. As seen in table 5 a number of excipients besides the API are used. CCS or Crosscarmellose is an excipient which reacts fast after oral administration to disintegrate enhancing bioavailability. Crosspovidone or CRP is another excipient and like CCS it is a dieintegrant in pharma dosage forms allows absorption. Starch also acts as an…

    Words: 1622 - Pages: 7
  • Meter Dose Inhaler Research Paper

    Over view of Meter dose Inhaler Regulation in US and EUROPE. Introduction A metered-dose inhaler (MDI) is a device that delivers a specific amount of medication to the lungs, in the form of a short burst of aerosolized medicine that is usually self-administered by the patient via inhalation. It is the most commonly used delivery system for treating asthma, chronic obstructive pulmonary disease (COPD) and other respiratory diseases. Metered-dose inhaler products contain therapeutically active…

    Words: 2596 - Pages: 11
  • Dex-Ibuprofen Research Paper

    solution aliquots of 0.2,0.4,0.6,0.8,0.10 µ/mlwere withdrawn in 10 mL volumetric flask and diluted up to the volume with methanol and phosphate buffer (ph 7.4) solutions to give concentrations of 2,4,6,8,10 g/mL. Absorption of each solution as calculated at 227.2 nm ,223nm using Elico SL 210 UV-1700 UV Visible double beam spectrophotometer and methanol as well as phosphate buffer (ph 7.4) as a reference standard correspondingly. Compatibility studies The compatibility of drug and polymers…

    Words: 1362 - Pages: 6
  • Analysis Of Atorvastatin

    PRE FORMULATION STUDY: Pre formulation testing was an investigation of physical and chemical properties of a drug substance alone and when combined with excipients. It was the first step in the rational development of dosage forms. Class: -Pre formulation study can divide into two subclasses: API characterization, Compatibility study Active pharmaceutical ingredient (API) characterization:- Organoleptic evaluation:-These are preliminary characteristics of any substance which is useful in…

    Words: 1621 - Pages: 7
  • Estimation Of Raloxifene Hydrochloride

    of concentrations in the range of 100-500µg/mL were obtained by further dilution of the aliquots with methanol. All the solutions were stored at -20oC and were equilibrated to room temperature prior to use. To prepare the standard calibration samples, 50µL of standard solution were added to 100µL of liver homogenate. The mixture was vortex-mixed for 10 min; followed by centrifugation at 4000 rpm for 15 min. 20µL of the supernatant was taken, then filtered through 0.22µm size syringe filter and…

    Words: 777 - Pages: 4
  • Importance Of Biopharmaceutics

    absorption and also other essential events that follows before the therapeutic effect of a drug is observed or achieved. Drug Drugs are chemically synthesized or naturally extracted from animals and plants which are then processed into chemical substances which are then formulated into final dosage forms or drug products based on their route of administration, physiochemical nature, dose required and even based on excipients to be formulated with, in some cases. Drugs are in form of solutions,…

    Words: 1493 - Pages: 6
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