Advantages And Treatments Of The Multiparticulate Drug Delivery System

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Reservoir Systems consist of a hollow inner core and a polymer membrane, there to control the rate of drug diffusion. Drug diffusion across the membrane is rate limited and controls general drug release rate (Bajpai et al. 2008). For reservoir systems drug release normally remains steady resulting in a zero order profile (Raval, Parikh and Engineer, 2010). Another technology is called the Multiparticulate drug delivery system which consists of microencapsulated granules/beads containing drug packed inside a capsule or compressed into a tablet (Patwekar, and Baramade, 2012). This system is highly fitting to achieve controlled release oral formulations and is advantageous compared to conventional therapy due to the fact that Multiparticulate …show more content…
There are currently two systems of matrix delivery system including hydrophobic matrix tablets (Abdel-Rahman, Mahrous and El-Badry, 2009) which release drug after the tablet has been dissolved by a solvent and hydrophilic matrix tablets (Asija and Bansal, 2013) which are dependent upon the swelling of the outer layer of the tablet to allow drug to diffuse out (Kim, 1995). Both of these systems consist of drug inside a matrix tablet which will be released over a prolonged amount of time. Hydrophobic polymers are widely accepted for use as they offer many advantages such as exhibiting superior stability at different pH’s (Tiwari et al., 2003). But in this project hydrophilic tablets are going to be used to test the effect of different variables on drug …show more content…
They are one of the most common ways of implementing controlled release, due to their ability of producing a wide array of desirable drug profiles (Bhupendra and Patel, 2010), they are simple, are one of the most cost effective methods to produce extended release tablets (Prajapati and Patel, 2010) (Tiwari and Rajabi-Siahboomi, 2008), and can accept a broad range of different polymers including Hydroxypropylmethylcellulose (HPMC) and PEO (Patel, Panchal and Patel, 2015). When a hydrophilic matrix tablet comes into contact with an aqueous medium the surface of the tablet swells to form a gel layer which exhibits a gelatinous shape (Wilson and Crowley, 2011). This gel layer formed will govern the rate at which drug is released from the tablet (Shah, Chaudhary and Mehta, 2014) and it can be concluded that drug release for hydrophilic tablets are governed by swelling of the polymer rather than erosion. But there is also another factor that affects release which is the rate at which hydration occurs, this factor is controlled by the structure of the gel formed. These gels formed are known to be interlinked networks and between the networks are tortuous pathways through which drug can diffuse. As a result the release of drug can be influenced by many factors as well as polymer concentration, such that by increasing polymer concentration, the rate of diffusion

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