Diclofenac Sodium Lab Report

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NANOCARRIERS AS PROMISING NOVEL SYSTEMS FOR CONTROLLED DELIVERY OF DICLOFENAC SODIUM

[N.B: Authors' details blinded by Pro Journals for Review]

ABSTRACT

The formulation and evaluation of Diclofenac sodium from liposomes, niosomes and nanoemulsion are analyzed. The release profiles of Diclofenac sodium were almost similar in all the formulations. It is found that 85% of Diclofenac sodium diffused out from the colloidal systems within 8hrs and practically all the drug was released within 12hrs. In addition to this controlled release, the similarity of the release profiles obtained for liposomes, niosomes and nanoemulsion signifies that the internal structure has little role in the release process. The drug released fast and completely …show more content…
The surface charge was analyzed using a Zetasizer Nano ZS (Malvern, UK) at 25ºC by measuring the zeta potential (ZP) of the preparations. For this purpose the samples were diluted to appropriate concentration. The ZP characterizes the surface charge of dispersed phase and thus gives information about repulsive forces between vesicles and droplets. Absolute higher values than 30mV usually indicate good stability of the system. Also the size and ZP values were measured with time over 5 weeks during storage at room …show more content…
Conclusion

This work describes the development of colloidal systems of Diclofenac sodium. The interest of these Diclofenac sodium loaded colloidal systems was evidenced by the fact that they significantly prolonged the release of Diclofenac sodium. These colloidal systems released their drug content rapidly upon dilution. The similar behavior of the three systems indicates that the colloidal nature of the systems is the key factor responsible for their positive behavior. In conclusion, the results of this study emphasize the potential of liposomes, niosomes and nanoemulsions as promising future nanosystems for Diclofenac

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