Dex-Ibuprofen Poly Case Study

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ABSTRACT
Dex-Ibuprofen–polyethylene glycol (PEG) conjugates (PEG-dex-Ibu) were organized and their prospective as a prolonged release method was investigated. PEG-Dex-Ibuprofen conjugates were synthesized as of Ibuprofen and PEG with 4000 Da molecular weights by esterification in the incidence of DCC and DMAP. The PEG-dex-Ibu conjugates were characterized by FT-IR, 1H NMR, and DSC analysis. The solubility revise in aqueous system showed an improvement within the solubility of conjugates. The dissolution studies showed an accurate acid–base catalysis prototype reliant on the pH of the medium. This indicated a fine chemical constancy in aqueous buffer solution of acidic medium and the comprehensive discharge performance was found in prodrug after 6 hours. The consequences reveal that, in the same state, the rate of hydrolysis for PEG4000-dex-Ibu is slower than supplementary. These results recommend that PEG-Dex-Ibu could be a capable NSAID prodrug with an extended pharmacological effect owing to delayed-release of parent drug

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The mixture was stirred, and a white precipitate of dicyclohexyl urea (DCU) was created after 15–30 min. The reaction was monitored by thin layer chromatography (TLC). After approximately 6–8 h, the precipitate was filtered and the filtrate was evaporated to dryness. The resulting residue was dissolved in acetone, filtered to additional remove any DCU, and evaporated once more. 10% sodium bicarbonate was used to separate the PEG–dex-Ibu from free dex-Ibuprofen. The purified products were dried under vacuum. The pure PEG4000–dex-Ibu conjugate with the yield of 60.49% was obtained. The fact that there was no free drug of Dex- Ibuprofen available in polymer prodrug was established by thin layer chromatography and DSC measurements [25]. The scheme was mentioned in Figure no

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