Nimodipine Research Paper

Improved Essays
NIMOTOP INJECTION
Nimodipine 0.02% solution contains the following excipients:
Ethanol 96%, Macrogol 400, sodium citrate, citric acid, Water for Injections Ph. Eur.
These excipients consist of properties that aim towards the proper functionality of Nimotop. They consist of inherent stabilities that cause little or no effect in the stability of the drug and they do not have any acute or chronic toxicity. The excipients are also added into the Nimodipine 0.02% solution to enhance the biological activity of the drug.

Nimodipine is a yellow crystalline substance which is insoluble in water. Insoluble drugs have poor bio-availability and they may precipitate when given via an intravenous administration. However, there is a relatively simple solubilizing approach that can be used in
…show more content…
PEG has low toxicity with absorption into the body at less than 0.5%. Most importantly, PEG is a widely accepted co-solvent that is used in Nimotop 0.02% solutions. Lower molecular weight PEGs (Macrogol 400) are clear and viscous liquids with a characteristic bitter taste. Macrogol 400 is very stable in a solution and it functions to prevent microbial growth. This PEG is not only soluble in water and ethanol, but also relatively miscible with other PEGs. Therefore, Macrogol 400 is highly favored for use with other co-solvents. The resultant superior solubility in water of Nimotop may also be due to the ability of Macrogol 400 to form hydrogen bonds due to dipole-dipole interactions. Compounds with acidic hydrogen can react with oxygen of PEGs however even so, an overwhelming number of water molecules are present in aqueous solutions. Hence, reaction with Macrogol 400 only occurs to a moderate degree and this shows that it is an inherent excipient which is highly

Related Documents

  • Improved Essays

    Heartburn Research Paper

    • 833 Words
    • 4 Pages

    H2 blockers are proactive in their approach to the reduction of acid reflux, rather than reactive, like antacids. They work to reduce the production of stomach acid, so that the fluids in the stomach already have a higher pH if and when they do leak in to the esophagus. Because this altered stomach fluid is significantly less acidic, it will not have as detrimental of an effect on the esophageal tissue. Some common brands of H2 blockers are Tagamet, Pepcid, and Zantac. The last category of acid reflux prevention is the category of proton pump inhibitors.…

    • 833 Words
    • 4 Pages
    Improved Essays
  • Improved Essays

    This is because the stearic, oleic and linoleic acids counteract the cholesterol-raising effects of palmitic, lauric and myristic acid. In fact, palm oil is capable of being safely substituted for olive oil with the same heart health benefits. Palm oil is also solid at cooler temperatures, which confers a benefit in the form of not needing to be hydrogenated to make it solid. This avoids the formation of trans fats during the hydrogenation process. Palm oil has a smoke point of 235% and thus it can be deemed suitable for even deep frying, as it fails to volatilize quickly.…

    • 848 Words
    • 4 Pages
    Improved Essays
  • Superior Essays

    Alginate is more prefer to be used due to its biocompatibility, low cost and low toxicity. In this work, sodium alginates (SA) were used to investigate the physical and mechanical properties. Sodium alginate act as a hydrophilic and it can be dissolved in water but not entirely soluble (Ilie et al.,…

    • 1102 Words
    • 5 Pages
    Superior Essays
  • Improved Essays

    The business shall entail the conversion of the natural gas to a special powder form known as methane gas hydrate (commonly referred to as dry water). The process shall entail mixing the natural gas with water under high pressure and low temperature. It facilitates reaction of the mixture to form methane gas hydrate, a powder resembling granulated sugar. This powder makes it easier to store and transport as opposed to the pressurized canisters and pipelines. In addition, it occupies lesser space leading to more quantities transported at a go with reduced expenses.…

    • 839 Words
    • 4 Pages
    Improved Essays
  • Superior Essays

    It is rich in omega-3 and omega-6 fatty acids, vitamin E and antioxidants. Also, it contains non-saturated and unsaturated fatty acids which are known to be good for heart. Mustard oil is widely used as cooking oil in Indian households because of its many health benefits over refined oil. It is viscous and has a strong odor. Because of its viscosity it is mixed with coconut oil, almond oil or other ingredients for skin and hair applications.…

    • 1083 Words
    • 5 Pages
    Superior Essays
  • Superior Essays

    In general, organic acids are weak acids and do not dissociate completely in water, whereas the strong mineral acids do. Lower molecular mass organic acids such as formic and lactic acids are miscible in water, but higher molecular mass organic acids, such as benzoic acid, are insoluble in molecular (neutral) form. A few examples of organic acids include: • Acetic acid (ethanoic acid ) CH3COOH • Citric acid…

    • 1687 Words
    • 7 Pages
    Superior Essays
  • Improved Essays

    Disease Risk Reduction Mono and polyunsaturated fats are usually seen as “good” fats. They are found in foods like cold water fish and olives. Saturated fats have gotten to be know as “bad” fats and can be found in butter and coconut oil. There are no good or bad fats when they are part of one’s balanced diet. The easy way to identify an unsaturated fat is the property that they are a liquid at room temperature.…

    • 917 Words
    • 4 Pages
    Improved Essays
  • Improved Essays

    Thus, the reaction resulted in the production of a murky coloured liquid. If a full neutralization reaction was to completed, a product of a transparent solution should have been created. Sodium phosphate and potassium sodium tartrate are both not strong bases and that is why the average pH change was quite low. Both of them are not bases, however, they have a high pH. This is why they were both able to increase the pH on the acidic solution.…

    • 1215 Words
    • 5 Pages
    Improved Essays
  • Improved Essays

    Sodium Alginate Essay

    • 936 Words
    • 4 Pages

    Polyacrylamide (PAm) is one of the water soluble polymers with a hydrophilic side group and a hydrophobic main chain and is non-toxic [7]. PAm can form aqueous solution of high concentration. Crosslinked PAm is a well known hydrogel, whose swelling nature is not very sensitive to pH or to the presence of electrolytes. Due to its gelling property, it is used in gel electrophoresis, in manufacture of soft contact lens and as…

    • 936 Words
    • 4 Pages
    Improved Essays
  • Improved Essays

    Antacid Acid Experiment

    • 818 Words
    • 4 Pages

    When the juice was added to the test tube it immediately turned the water a fluorescent pink. The colour was not light enough to be considered a 2 but it was not a dark pink either so we labelled it as a 3 on the pH scale. Lemon juice is considered to be a strong acid however it is still completely safe to touch and to consume. The next solution tested was soft drink. After putting it into the test tube we noticed that it changed colour slower than the lemon juice.…

    • 818 Words
    • 4 Pages
    Improved Essays