Risperidone is atypical antipsychotics drug used in the treatment of mental and mood disorders. It is helping to restore the certain natural substances balance in the brain [xx]. Combined drugs containing risperidone may also be used in depression treatment [???].Maximum concentration (Cmax) occurs during two hours following oral administration. Rate and extent of risperidone absorption does not affect by food. It is metabolized mainly by CYP450- 2D6 (CYP2D6), through hydroxylation giving 9-OH-risperidone, which have pharmacological effects like parent drug, risperidone [8-10]. Elimination half-life is variable in different patients according to the genetic polymorphism. Elimination lasting long time in poor metabolite individuals
