Excipient

The aim of the present investigation is to intend, develop and evaluate a pulsatile drug delivery containing a core-in-cup based system of dry coated tablet of ketoprofen based on chronomodulated approach for management of Rheumatoid Arthritis. This pulsatile system contained a core tablet surrounded by an impermeable outer shell and top cover layer. Core tablet contained the active ingredient acting as reservoir, ethylcellulose was used to form an impermeable outer shell, the top cover layer…

Solubility studies The solubility of docetaxel in various vehicles selected as oil, surfactant and co-surfactant for formulation of L-SNEDDS was determined and presented in the Table 1. Among the tested vehicles, Capmul PG8 NF (>250 mg/mL), Capmul MCM C8 (>250 mg/mL) and Transcutol P (>200 mg/mL) had the highest drug solubilization capacity for docetaxel. Whereas, Captex and Gelucire 44/14 shown the least solubility of docetaxel in them. Based on the solubility results, Capmul PG8 NF…

The United States is known to be a great country because of our freedom to have our beliefs and values. Our nation has become this great land that at times is overwhelming. Our government has progressed since our founding fathers. The problem lies on how much power the government has. Immunizations are one of the many things that the American people have no voice in, even though vaccinations on children have been a big controversy to many Americans because of the side effects they might have…

The Right to Choose Immunizations Thesis Paper Immunization rights are currently becoming a highly debatable ethical issue. Immunization is the method by which an individual is made immune or resistant to an infectious disease. Vaccines enable the body’s immune system to protect against disease or infection. There is much debate arising about whether individuals have the right to choose to vaccinate their children. Are vaccines safe enough that it be mandated for all or should there be a…

Cyclodextrins are enzymatically modified starches composed of glycopynanose units which form a ring of either six (α-cyclodextrin), seven (β-cyclodextrin) or eight (γ-cyclodextrins) units. Characteristics of β-cyclodextrins include: • Glucose unit: 07 • Molecular weight: 1135 • Solubility =1.85g/100ml • Cavity diameter = 6.4 Ǻ • Diameter of outer periphery = 15.4 Ǻ • Approx. volume of cavity = 262 (Ǻ)3 Cyclodextrins have a cylindrical shape with central axial cavity and resembles the shape of a…

INTRODUCTION: Pharmaceutical field is the research and development intensive field. The search for safe and effective drugs continues to be major efforts for all the pharmaceutical industries. There are enormous complexities for discovering and testing new drugs because of the many aspects of safety, efficacy and economics which determines the acceptability of a drug. Nose is one of the delicate organs of the human body, as a result of which nasal drug delivery is challenge for formulator.…

RESULT AND DISCUSSION 7.1. Preformulation studies 7.1.1. Identification of pure drug by FTIR Figure7.1: Identification of Sample through FTIR Figure 7.2: FTIR Spectrum of Standard Prazosin hydrochloride (with references of B.P.- 2009) Table: 7.1 - Characteristics peaks of Prazosin hydrochloride S.No. Reference peaks (cm-1) Theoretical peak of Prazosin hydrochloride Obtained peaks (cm-1) Functional Group Stretching/ Bending 1 1750-1680 1529.92 1529.92 C=O Stretching 2. 1650-1580…

class: Central nervous stimulants (Wake- promoting agents) (Ballon and Feifel, 2006) Formulation: Modavigil ® is formulated as modafinil white to off-white, crystalline powder in tablet form. It is available in tablets containing 100mg of modafinil. Excipients in the tablet are: lactose, strach, pregelatinised maize, maicrocrystaline cellulose, croscarmellose sodium, providone and magnesium stearate (Medsafe, 2015). Indications: Modavigil ® is indicated as a treatment for excessive daytime…

The objective of work was to optimize, formulate, evaluate and compare the transdermal gel containing vesicle based: Transfersomes and liposomes, containing Ketoconazole, an anti-fungal bioactive. Ketoconazole loaded Transfersomes were prepared using thin film hydration method with different concentration of surfactant (Span80, Tween80, and Sodium Deoxycholate) and soya lecithin and characterized for various parameters including Vesicles Size, Morphology, Entrapment Efficiency, Drug Loading…

the gas bubbles in the reacting medium. The bubbles in foam can be more or less homogeneous and vary in size. The shape of bubble of the foam may be almost spherical to irregular polyhedral, based on the way in which the foam is generated and the excipients used (Nikolai et al., 2009). Other parameters include the nature and concentration of the foaming agent, viscosity of the liquid phase,…