FTIR Spectrum Of Standard Prazosin Hydrochloride

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RESULT AND DISCUSSION
7.1. Preformulation studies
7.1.1. Identification of pure drug by FTIR

Figure7.1: Identification of Sample through FTIR Figure 7.2: FTIR Spectrum of Standard Prazosin hydrochloride (with references of B.P.- 2009) Table: 7.1 - Characteristics peaks of Prazosin hydrochloride

S.No. Reference peaks (cm-1) Theoretical peak of Prazosin hydrochloride Obtained peaks (cm-1) Functional Group Stretching/
Bending
1 1750-1680 1529.92 1529.92 C=O Stretching
2. 1650-1580 1651.70 1651.70 N-H Bending
3. 1335-1250 1385.08 1385.08 C-N Stretching
4. 1320-1000 1146.18 1146.18 C-O Stretching
5. 900-800 884.13 884.13 C-C Stretching
The comparison between the peak of two graph shows that the characteristic peak of Prazosin hydrochloride
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6 32.61 28.19 36.17 32.15
6. 8 37.68 31.26 41.61 36.38
7. 10 42.63 36.23 46.35 40.32

Table No. 7.10: In- vitro permeation profile of Prazosin hydrochloride from Formulation F1
S.No T √T Log T Cumulative % drug release Cumulative %drug remain Log Cumulative % drug release log Cumulative %drug remain
1 0 0 - 0 100 - 2
2 1 1 0 12.02 87.98 1.07 1.94
3 2 1.414 0.3 21.32 78.68 1.32 1.89
4 4 2 0.6 26.65 73.35 1.42 1.86
5 6 2.449 0.77 32.61 67.39 1.51
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7.11: In- vitro permeation profile of Prazosin hydrochloride from Formulation F2
S.No T √T Log T Cumulative % drug release Cumulative % drug remain Log Cumulative % drug release Log Cumulative % drug remain
1 0 0 - 0 100 - 2
2 1 1 0 8.31 91.69 0.91 1.96
3 2 1.414 0.3 17.45 82.55 1.24 1.91
4 4 2 0.6 25.04 74.96 1.39 1.87
5 6 2.449 0.77 28.89 71.11 1.46 1.85
6 8 2.828 0.9 31.26 68.74 1.49 1.83
7 10 3.16 1 36.23 63.77 1.55 1.80

Table No. 7.12: In- vitro permeation profile of Prazosin hydrochloride from Formulation F3
S.No T √T Log T Cumulative % drug release Cumulative % drug remain Log Cumulative % drug release Log Cumulative % drug remain
1 0 0 - 0 100 - 2
2 1 1 0 15.74 84.26 1.19 1.92
3 2 1.414 0.3 23.65 76.35 1.37 1.88
4 4 2 0.6 32.25 67.75 1.50 1.83
5 6 2.449 0.77 36.17 63.83 1.55 1.80
6 8 2.828 0.9 41.61 58.39 1.61 1.76
7 10 3.16 1 46.35 53.65 1.66 1.72

Table No. 7.13: In- vitro permeation profile of Prazosin hydrochloride from Formulation F4
S.No T √T Log T Cumulative % drug release Cumulative % drug remain log Cumulative % drug release log Cumulative % drug remain
1 0 0 - 0 100 - 2
2 1 1 0 9.37 90.63 0.97 1.95
3 2 1.414 0.3 18.25 81.75 1.26

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