Ketoprofen Core Tablets Case Study
Accurately measured quantities of drug, superdisintegrant, diluent were passed through sieve no. 45 seperately, mixed by geometric addition technique, taken and blended properly for 15 min to it glident and antiadherant were added finally, then 100mg blend was weighed and compressed using 6mm flat punches on 16 station tablet punching machine. (Cadmach, Ahmedabad, India).
Preparation of Ketoprofen core-in-cup pulsatile tablets (KPT):
An impermeable coating cup consisting of ethylcellulose was applied underneath and around the core tablet. Ethylcellulose powder (90 mg) was filled into a die of 10mmflat punches and then was quietly flattened to make a powder bed with a flat surface. The core tablet was cautiously placed in the midpoint of the powder bed, and then the gap between the core tablet and the die was filled manually with 60 mg of ethylcellulose so that the surrounding surfaces of the core tablet were fully covered. Different plug polymers (Table 2) were added at the top of the core tablet surrounded by the cup. The tablet was compressed to produce the desired core-in-cup pulsatile