The aim of the present investigation is to intend, develop and evaluate a pulsatile drug delivery containing a core-in-cup based system of dry coated tablet of ketoprofen based on chronomodulated approach for management of Rheumatoid Arthritis. This pulsatile system contained a core tablet surrounded by an impermeable outer shell and top cover layer. Core tablet contained the active ingredient acting as reservoir, ethylcellulose was used to form an impermeable outer shell, the top cover layer contained different hydrophilic polymers like SodiumAlginate, HPMCK4M, Sodium carboxymethylcellulose with different concentrations. The formulations were evaluated for various pre-compressional and post-compressional parameters. The effect of polymer properties
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Hence, chronotherapeutic medication conveyance framework (ChDDS) might make handy for such patients since the medication is discharged during a foreordained lag time. Chronotherapeutics alludes all the will a medication strategy previously, which in vivo medication accessibility is timed to match those rhythms for disease, in place will streamline restorative results, furthermore minimize side impacts [6,9,10]. It will be outlined such medication discharge will be adjusted to a way that ensures that greatest centralization of the medication regardless may be arrived at in the maximum intensity of the disease state.
Chronomodulated drug delivery system (ChDDS) can be distinct as a system where drug is released suddenly after a well-defined lag time according to the circadian rhythm of the disease [11,12]. ChDDS can be classified according to the pulse-regulation of drug release into three main classes; time-controlled pulsatile release (single or multiple unit system), internal stimuli induced release and external stimuli-induced pulsatile release systems [13]. PDDS can also be classified according to the dosage form into three main types; capsules, pellets and tablets among which the ‘core-in-cup’ tablet …show more content…
Accurately measured quantities of drug, superdisintegrant, diluent were passed through sieve no. 45 seperately, mixed by geometric addition technique, taken and blended properly for 15 min to it glident and antiadherant were added finally, then 100mg blend was weighed and compressed using 6mm flat punches on 16 station tablet punching machine. (Cadmach, Ahmedabad, India).
Preparation of Ketoprofen core-in-cup pulsatile tablets (KPT):
An impermeable coating cup consisting of ethylcellulose was applied underneath and around the core tablet. Ethylcellulose powder (90 mg) was filled into a die of 10mmflat punches and then was quietly flattened to make a powder bed with a flat surface. The core tablet was cautiously placed in the midpoint of the powder bed, and then the gap between the core tablet and the die was filled manually with 60 mg of ethylcellulose so that the surrounding surfaces of the core tablet were fully covered. Different plug polymers (Table 2) were added at the top of the core tablet surrounded by the cup. The tablet was compressed to produce the desired core-in-cup pulsatile
Hence, chronotherapeutic medication conveyance framework (ChDDS) might make handy for such patients since the medication is discharged during a foreordained lag time. Chronotherapeutics alludes all the will a medication strategy previously, which in vivo medication accessibility is timed to match those rhythms for disease, in place will streamline restorative results, furthermore minimize side impacts [6,9,10]. It will be outlined such medication discharge will be adjusted to a way that ensures that greatest centralization of the medication regardless may be arrived at in the maximum intensity of the disease state.
Chronomodulated drug delivery system (ChDDS) can be distinct as a system where drug is released suddenly after a well-defined lag time according to the circadian rhythm of the disease [11,12]. ChDDS can be classified according to the pulse-regulation of drug release into three main classes; time-controlled pulsatile release (single or multiple unit system), internal stimuli induced release and external stimuli-induced pulsatile release systems [13]. PDDS can also be classified according to the dosage form into three main types; capsules, pellets and tablets among which the ‘core-in-cup’ tablet …show more content…
Accurately measured quantities of drug, superdisintegrant, diluent were passed through sieve no. 45 seperately, mixed by geometric addition technique, taken and blended properly for 15 min to it glident and antiadherant were added finally, then 100mg blend was weighed and compressed using 6mm flat punches on 16 station tablet punching machine. (Cadmach, Ahmedabad, India).
Preparation of Ketoprofen core-in-cup pulsatile tablets (KPT):
An impermeable coating cup consisting of ethylcellulose was applied underneath and around the core tablet. Ethylcellulose powder (90 mg) was filled into a die of 10mmflat punches and then was quietly flattened to make a powder bed with a flat surface. The core tablet was cautiously placed in the midpoint of the powder bed, and then the gap between the core tablet and the die was filled manually with 60 mg of ethylcellulose so that the surrounding surfaces of the core tablet were fully covered. Different plug polymers (Table 2) were added at the top of the core tablet surrounded by the cup. The tablet was compressed to produce the desired core-in-cup pulsatile