Traditional Chinese Medicine Case Study

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4. Analysis of Traditional Chinese Medicines (TCM) [26]
The identification and quantification of components of traditional TCM by chromatographic analysis (HPLC) is one of the major challenge. As TCM is a complex matrices in which all the constituents plays specific role for the overall efficacy. So the analysis of all the constituents synchronously is necessary to quality control the TCM. So the new technique UPLC is used for the quality control of the TCM.
5. Multi-residue analysis of pharmaceuticals inwaste water [27]
The water used in the pharmaceutical companies are found to have the traces of various antibiotics, analgesics andanti-inflammatory, anti-ulcer agents, beta-blockers, lipid regulating agent’s, cholesterol lowering statin agents,
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For the development of robust and reliable method, the labs are required to study various combinations of different parameters mobile phase, temperature, pH, column and gradient chemistry etc. UPLC plays an important role in the laboratory which reduces the cost and increases the efficiency of analysis required for developing and validating the method. With UPLC, the speed of the separations increases and efficiency improves, which results in the fast development of methodologies. Some of the advantages of the UPLC: a) High stability of the UPLC Columns provides possibility of selection of column temperature and pH from a wide range. b) It is possible to use HPLC methods on the UPLC as the UPLC Column manager evaluates the column temperature between and below 10°C to 90°C. c) UPLC calculator keeps information at …show more content…
High Resolution Analysis of Glimpiride Forced Degradation on BEH C18
11. Dissolution Testing [29]
Dissolution testing is one of the most important steps carried out for the drug release testing in formulation and manufacturing process. The dissolution data provides understanding to validate consistency and uniformity of the active ingredient in every batch. Testing of potent drugs in sustained release dosage form is very important as their dissolution studies data affect the delivery of the medicine. Moreover, new and potent formulations require higher separation sensitivity. UPLC method provides accurate and consistent automated online sample acquirement.
12. Bioequivalence / Bio-analysis Studies [29]
Bioequivalence studies are pharmacokinetic studies needed for the quantitation of a drug in biological samples. During bioequivalence studies, quantitative bio analysis is an important step to compare the rate and exposure level of newly developed formulations of prevailing drugs to permit the drugs to reach the bloodstream with that of original formulation. The selectivity and sensitivity of UPLC-MS/MS at low detection levels produce reliable and precise data. UPLC- MS/MS solutions have increased efficacy, output and profitability for the bioequivalence laboratories. UPLC sample manager enhances the effectiveness by considering huge numbers of samples in a temperature-controlled atmosphere, confirming maximum throughput which increases the sensitivity and quality of

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