Aspirin

Aspirin: Composition and Purity Introduction: Aspirin is a widely used over-the-counter pain reliever/fever reducer. Chemically aspirin is known as acetylsalicylic acid, it is formed when acetic anhydride and salicylic acid react with the addition of phosphoric acid, which behaves as a catalyst. (French et al. 82) The purpose of this experiment was to react acetic anhydride with salicylic acid to produce pure aspirin and acetic acid, a by-product of the reaction. At the completion of this reaction the mass of pure aspirin produced can be measured. Once the experiment is concluded the theoretical yield of aspirin can be calculated. To calculate the theoretical yield the following chemical formula will be used: (CH_3 〖CO)〗_2 O (aq)+HOC_6 H_4…

The purpose of this experiment was to synthesize aspirin. The starting materials, salicylic acid and acetic anhydride react causing aspirin to form. The oxygen of the acetic anhydride carbonyl is protonated, and the oxygen of the phenol group does a nucleophilic attack at the carbonyl that is protonated. The double bond between the carbonyl is broken causing a tetrahedral intermediate to form. Acetic acid leaves, and the carbonyl group is formed again. The remaining proton on the carbonyl oxygen…

Here is an interesting fact about aspirin: one hundred billion aspirin tablets are consumed yearly on Earth. That is four hundred thousand tons of aspirin (Dodziuk, 2013). Aspirin is a very common household drug and it is very widely used in the medical industry today. Most people know this drug as a pain reliever. However, it can do many other things than just that. Aspirin is not a drug that produces anesthesia or causes someone to lose consciousness. Aspirin is also used to reduce fevers,…

investigate whether different formulations of aspirin would affect its bioavailability. This required the use of normal aspirin tablets, aspirin tablets with sodium bicarbonate, soluble aspirin, and enteric coated aspirin. Depending on which group the students were allocated they administered different formulations of aspirin. The pH and the concentration of salicylate in each urine sample, collected at different time points, was determined after administering the drug. A standard curve for…

extract aspirin, caffeine, and acetaminophen from a tablet of pain medication acid and base extraction techniques were used to exploit the differences in solubility between the components. This is achieved by using a separatory funnel and three different solvents, 4M HCl which separated the caffeine, deionized water which separated the acetaminophen, and 5% wt/vol NaHCO3 which separated the aspirin. Once the solution of the crushed tablet and ethyl acetate was mixed with a solvent in the funnel…

recrystallisation to purify aspirin. The experiment also allows students to carry out the synthesis of aspirin, build up their skills on recrystallisation and build up their recrystallisation techniques. To prepare aspirin, acetic anhydride was added to salicylic acid, after which, sulfuric acid was added and heated for some time to allow the reaction to be completed. On top of the addition of distilled water, cold water was also added. With the use of suction filtration, a crude product was…

Medicine has evolved greatly, especially in terms of drugs, but one of the basics is aspirin, also referred to as acetylsalicylic acid. There are many different reactions that can be conducted in order to synthesize aspirin. One way being the Fischer esterification, which is a reaction between an alcohol and a carboxylic acid within the presence of a catalyst, synthesizing an ester (Weldegirma, 2014). The catalyst has to be something that will provide the addition of a proton, such as a Lewis…

Aspirin Effects on Sunflower Germination TESTABLE QUESTION: What are the effects of different amounts of aspirin on sunflower germination? BACKGROUND: Aspirin is probably the most well-known pain killer. Aspirin is a salicylate, a bitter compound present in certain plants, and a nonsteroidal anti-inflammatory drug. Aspirin can treat headaches, pain, fever, and inflammation. It can also decrease the risk of a heart attack, strokes, and chest pain. It works by blocking a certain natural…

Research Article Pharmacy Practice GELLIFIED EMULSION FOR SUSTAIN DELIVERY OF ASPIRIN AS ANTI-INFLAMMATORY INTRODUCTION Aspirin is a non-steroidal anti-inflammation drug (NSAID). It widely use as analgesic in treating mild to moderate pain such as injury, headache, arthritis, menstrual cramp and other musculoskeletal condition. Aspirin is an ester of salicylic acid, while after ingestion it will undergoes hydrolysis which produce salicylic acid and acetic acid. Salicylic acid…

Abstract: The objective of this experiment was to synthesize aspirin from salicylic acid and acetic anhydride. The general theory behind this experiment was to study the synthesis of a drug from organic materials. During the experiment, esterification had occurred between reactants salicylic acid and acetic anhydride. Then, phosphoric acid would catalyze the reaction and water would be added to decompose the remaining acetic anhydride. Through the process of filtration, aspirin crystals were…