investigate whether different formulations of aspirin would affect its bioavailability. This required the use of normal aspirin tablets, aspirin tablets with sodium bicarbonate, soluble aspirin, and enteric coated aspirin. Depending on which group the students were allocated they administered different formulations of aspirin. The pH and the concentration of salicylate in each urine sample, collected at different time points, was determined after administering the drug. A standard curve for salicylate was generated to calculate its concentration in each urine sample by comparing the optical density using the following equation:
change in optical density (from control)×1/(gradient of graph)=concentration…
Here is an interesting fact about aspirin: one hundred billion aspirin tablets are consumed yearly on Earth. That is four hundred thousand tons of aspirin (Dodziuk, 2013). Aspirin is a very common household drug and it is very widely used in the medical industry today. Most people know this drug as a pain reliever. However, it can do many other things than just that. Aspirin is not a drug that produces anesthesia or causes someone to lose consciousness. Aspirin is also used to reduce fevers,…
Medicine has evolved greatly, especially in terms of drugs, but one of the basics is aspirin, also referred to as acetylsalicylic acid. There are many different reactions that can be conducted in order to synthesize aspirin. One way being the Fischer esterification, which is a reaction between an alcohol and a carboxylic acid within the presence of a catalyst, synthesizing an ester (Weldegirma, 2014). The catalyst has to be something that will provide the addition of a proton, such as a Lewis…
Research Article Pharmacy Practice
GELLIFIED EMULSION FOR SUSTAIN DELIVERY OF ASPIRIN AS ANTI-INFLAMMATORY
Aspirin is a non-steroidal anti-inflammation drug (NSAID). It widely use as analgesic in treating mild to moderate pain such as injury, headache, arthritis, menstrual cramp and other musculoskeletal condition.
Aspirin is an ester of salicylic acid, while after ingestion it will undergoes hydrolysis which produce salicylic acid and acetic acid. Salicylic acid…
Aspirin Effects on Sunflower Germination
TESTABLE QUESTION: What are the effects of different amounts of aspirin on sunflower germination?
BACKGROUND: Aspirin is probably the most well-known pain killer. Aspirin is a salicylate, a bitter compound present in certain plants, and a nonsteroidal anti-inflammatory drug. Aspirin can treat headaches, pain, fever, and inflammation. It can also decrease the risk of a heart attack, strokes, and chest pain. It works by blocking a certain natural…
Abstract: The objective of this experiment was to synthesize aspirin from salicylic acid and acetic anhydride. The general theory behind this experiment was to study the synthesis of a drug from organic materials. During the experiment, esterification had occurred between reactants salicylic acid and acetic anhydride. Then, phosphoric acid would catalyze the reaction and water would be added to decompose the remaining acetic anhydride. Through the process of filtration, aspirin crystals were…
Identification of Analgesic Drugs by Thin-Layer Chromatography
In thin-layer chromatography alumina or silica is used as the adsorbent material.
The filter paper is placed inside the beaker during separation to act as an adsorbent medium.
The ultraviolet lamp is used after TLC separation to illuminate the TLC sheet.
Aspirin, acetaminophen, and caffeine are components of analgesic drugs examined in this experiment.
A 6cm by 10cm pre-coated TLC sheet will be obtained. On the…
Salicylic acid’s hydroxyl group readily reacts with acetyl groups in a process called acetylation. The resulting substitution reaction replaces the hydrogen in salicylic acid’s hydroxyl group with an acetyl group thereby forming an ester functional group. This esterification of salicylic acid produces acetylsalicylic acid, or aspirin. Figures 1 and 2 above show the reagents and products involved in the experiment’s esterification of salicylic acid. With excess acetic anhydride and a…
Impurities in this experiment can result from incomplete acetylation of aspirin or hydrolysis of the aspirin during the isolation steps. The first test to determine the purity of the sample was to take the mass of the of acetylsalicylic acid product and compare it to the theoretical yield. The percent yield of the acetylsalicylic acid sample was 99.36% which indicates that the experiment was successful and followed the rules of chemistry. The second test to determine the purity of the sample was…
may be used a sedatives, hypnotics or as part of anaesthesia. Some barbiturates are used to relieve tension or anxiety prior to surgery.
Anti-Inflammatory drugs are used to reduce inflammation and irritation. For example: Ibuprofen
Antibiotic is used to treatbacterial diseases. They work by killing bacterial cells for example chest infections. Some Antibiotics include Erythromycin.
Demonstrate the knowledge and understanding the methods of developing new drugs