Aspirin

General Facts: • Aspirin is an acetyl derivative of salicylic acid. It works by reducing substances in the body that cause pain. • Its scientific name for Aspirin is Acetylsalicylic Acid. • Another common name for Aspirin is ASA. • Its chemical formula is C9H8O4 . • It has a melting point of 136 degrees Celsius and a boiling point of 140 degrees Celsius. • It's odorless, colorless and can be white powder. Historic background: • The origin of aspirin has evolved for the past centuries going…

Impurities in this experiment can result from incomplete acetylation of aspirin or hydrolysis of the aspirin during the isolation steps. The first test to determine the purity of the sample was to take the mass of the of acetylsalicylic acid product and compare it to the theoretical yield. The percent yield of the acetylsalicylic acid sample…

chromatography (TLC). Using the thin-layer chromatography to determine the composition of the Acetaminophen, Aspirin, Caffeine and Salicylamide, then compared with unknown analgesics. Experiment Scheme Acetaminophen Aspirin Caffeine Salicylamide C8H9NO C9H8O4 C8H10N C7H7NO Figure 1. The Chemical structure of Acetaminophen, Aspirin, Caffeine and Calicylamide. Obtain two TLC plates and 12 capillary micropipettes. Using a lead pencil…

What is a Drug? This is a chemical substance or medicine that has a physiological effect when ingested or introduced into the body. Types of Drugs: Anti-depressants: Antidepressants are drugs used for the treatment of major depressive disorder and other conditions. Antidepressants work by increasing levels of a group of chemicals in the brain called neurotransmitters. Certain neurotransmitters, can improve mood and emotion. Some anti-depressants drugs include Noradrenalin. Anti-Convulsants:…

Identification of a proper mobile phase to separate common analgesics used in over-the-counter pain relievers was essential in being able to determine the active ingredient in Advil. Therefore, in Procedure 1 TLC trials were ran for acetaminophen, aspirin, caffeine, and ibuprofen in different mobile phases composed of various proportions of ethyl acetate and hexane. The Rf values were recorded in Table 1. Based on this data, a mobile phase composed of 80% ethyl acetate and 20% hexane was…

Recently, marijuana and prescription medications have been vigorously debated since numerous states in the United States have legalized medicinal marijuana, and in a recent event in the world, Uruguay legalized marijuana and the government regulates and sells it. Many marijuana researchers are saying that marijuana could end the need for most prescription drugs because marijuana can help with such a diverse amount of illnesses and diseases. Marijuana, compared to prescription medications from a…

chromatography and analysis of Recrystallized Acetylsalicylic Acid by Spectroscopy to compare these results with another experiment about creating an Aspirin from Salicylic Acid. In this experiment, 0.1241 gram of Recrystallized ASA was produced from 1.1754 gram of Crude ASA and the yield of reaction is 10.56%. This yield is lower than the yield by creating an Aspirin from Salicylic Acid because the crystallized product is purer because we did not add another chemical in. For the melting point…

separation to illuminate the TLC sheet. (d) Aspirin, acetaminophen, and caffeine are components of analgesic drugs examined in this experiment. 2 A 6cm by 10cm pre-coated TLC sheet will be obtained. On the powdery surface of the TLC sheet, a light pencil line 1cm from the TLC sheet will be drawn. On this light pencil mark, five small dots will be drawn, 1cm between the dots and 1cm from the edges of TLC sheet. On the top of each drawn dot, will be marked as A (aspirin), Ac (acetaminophen), C…

Chromatography was to analyze compounds, Aspirin, a mixture of Tylenol with ethanol, acetaminophen, a mixture of Excedrin with ethanol, Aspirin, and acetaminophen, Anthracene, Benzyl, and Triphenylmethanol by separating them with the help of silica plates. Procedure Three silica plates were taken and on the plastic side, they were all marked 1 cm above its end using a pencil. With the help of capillary tube, the first and the second plates were spotted with Aspirin on the left and Acetaminophen…

called acetylation. The resulting substitution reaction replaces the hydrogen in salicylic acid’s hydroxyl group with an acetyl group thereby forming an ester functional group. This esterification of salicylic acid produces acetylsalicylic acid, or aspirin. Figures 1 and 2 above show the reagents and products involved in the experiment’s esterification of salicylic acid. With excess acetic anhydride and a concentrated acid, 0.510 g of salicylic acid should have yielded approximately 0.665 g…