Acetic anhydride

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  • The Synthesis Of Aspirin

    catalyst, synthesizing an ester (Weldegirma, 2014). The catalyst has to be something that will provide the addition of a proton, such as a Lewis acid, in order to provide a more reactive electrophile and speed up the reaction (Fischer Esterification Fischer-Speier Esterification, 2015). Some possibilities for the catalyst are sulfuric acid, tosic acid, and phosphoric acid (James, 2014). For the experiment, the starting materials are salicylic acid, acetic anhydride, and phosphoric acid. The salicylic acid is the compound that contained the alcohol and the acetic anhydride is the compound that contained the carboxylic acid. The main purpose of the acetic anhydride is to donate the acetyl to the salicylic acid, which in the end produces acetylsalicylic acid.Experimental Section Mix salicylic acid, 85% phosphoric acid, acetic anhydride, and a boiling stone in a conical vial. Monitor by TLC, 1:1hexane:EtOAc, followed by heating reaction in steam bath for 5 minutes. Take another TLC, add water to reaction to decompose excess acetic anhydride and cool to room temperature. Place vial in ice bath to for 10 minutes to allow crystallization, and then remove solvent using vacuum filtration on a Hirsch funnel. Dry product, weight it, conduct IR, proton NMR, and carbon NMR. The data showed that there was a percent yield of 55%. Also, when looking at the IR spectrum on can see that it I very erratic and ridged, which makes it difficult to interpret. The state of the IR spectrum could…

    Words: 746 - Pages: 3
  • Aspirin Synthesis Lab Report

    synthesize aspirin from salicylic acid and acetic anhydride. The general theory behind this experiment was to study the synthesis of a drug from organic materials. During the experiment, esterification had occurred between reactants salicylic acid and acetic anhydride. Then, phosphoric acid would catalyze the reaction and water would be added to decompose the remaining acetic anhydride. Through the process of filtration, aspirin crystals were collected and separate from the liquid acetic…

    Words: 993 - Pages: 4
  • Synthesizing Acetylsalicylic Acid

    Salicylic acid’s hydroxyl group readily reacts with acetyl groups in a process called acetylation. The resulting substitution reaction replaces the hydrogen in salicylic acid’s hydroxyl group with an acetyl group thereby forming an ester functional group. This esterification of salicylic acid produces acetylsalicylic acid, or aspirin. Figures 1 and 2 above show the reagents and products involved in the experiment’s esterification of salicylic acid. With excess acetic anhydride and a…

    Words: 1086 - Pages: 5
  • Willow Tree Lab Report

    structure of potassium hydrogen bis(acetylsalicylate). Results and Discussion: The purpose of this lab was to synthesize acetylsalicylic acid, otherwise known as aspirin, as purely as possible. This was done by reacting 2.00 g of salicylic acid with 5mL of 0.05 mole of acetic anhydride to create acetylsalicylic acid and acetic acid. During the reaction of salicylic acid and acetic anhydride, sulfuric acid was added to the reaction as a catalysis to speed up the reaction between the…

    Words: 1309 - Pages: 5
  • Acetaminophen Synthesis Lab Report

    Similar to the unique emission spectrum of different chemical elements, different esters release distinct fragrances. They are responsible for many odors such as those found in apples, bananas, strawberries, jasmine, and roses. The saturation of the ester along with its molecular weight determine the strength of the odor emitted. 3 Procedure: First, 1.005 g of 4-aminophenol was placed in a test tube, followed by 3.1 mL of water and 1.25 mL of acetic anhydride. The mixture in the test tube was…

    Words: 839 - Pages: 4
  • Synthesis Of P-Benbenediazonium Chloride Lab Report

    molecular weight compound in which many phenol rings are joined together by –CH2 groups. Reaction: Procedure: Take 5 mL of glacial acetic acid and 2.5 mL of 40% formaldehyde in a beaker. Add 2.5g of phenol into it. Cover the beaker with watch glass or filter paper. Add a few drops of HCl to it and place it on hot plate. Pink mass will be formed in the beaker. Wash, dry and weigh the product formed. Determine the melting point of the solid. Calculate the % yield of the product.…

    Words: 2234 - Pages: 9
  • Synthesis Of Aspirin Essay

    Aims: The objectives of this experiment are to carry out the process of synthesising aspirin and reinforce both the skills of recrystallisation and melting point determination. In this experiment, we are supposed to measure the amount of aspirin collected to calculate the percentage yield of aspirin. Apart from that, we are also required to find the melting point of aspirin. Introduction: 1.1: aspirin Aspirin, also known as acetylsalicylic acid, is an aromatic compound containing both a…

    Words: 1003 - Pages: 5
  • P Toluidine Synthesis Analysis

    the replacement of an amide with an amine. The result was a 66% yield of benzocaine which is significantly higher than the typical yield of the synthesis of benzocaine from p-toluidine as performed in this experiment. Ding and Chang-Ze describe the synthesis of benzocaine from p-nitrotoluene using KMnO4 as the oxidizing agent, which is the same as used in this experiment, SnCl4 as the catalyst, which differs from this experiment, and H2 as the reducer, which is the same as used in this…

    Words: 878 - Pages: 4
  • Nucleophilic Acyl Esterification Experiment

    A. Wilkinson. Blackwell Scientific Publications, Oxford (1997). XML on-line corrected version: http://goldbook.iupac.org (2006-) created by M. Nic, J. Jirat, B. Kosata; updates compiled by A. Jenkins. ISBN 0-9678550-9-8. doi:10.1351/goldbook. Appendices : Appendix A Answers to Questions 1. Le Chatelier’s Principle states that if a dynamic equilibrium is disturbed by changing the conditions, the position of the equilibrium moves to counteract the change. At equilibrium point, a…

    Words: 4123 - Pages: 17
  • Ibuprofen Case Study

    Stewart Adams, investigates and test other carboxylic acids and found that one, Propionic acid, tested nearly twice as strong as aspirin and had anti-inflammatory features. Ibuprofen was thus, derived from Propionic acid and is considered to be “an organic compound in the class of propionic acid derivatives.” (Broyles, 2014) Ibuprofen’s chemical systemic name is 2-(4-isobutylphenyl) propanoic acid and its’ chemical formula is (C13H18O2). Ibuprofen is slightly soluble in water but very soluble…

    Words: 2477 - Pages: 10
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