Excipient

ABSTRACT Solubility is the phenomenon of dissolution of solid in liquid phase to give a homogenous system.Solubility is one of the important parameter to achieve desired concentration of drug in systemic circulation for pharmacological response to be shown. Poor watersolubledrugs often require high doses in order to reach therapeutic plasma concentrations after oral administration. Low aqueoussolubility is the major problem encountered with formulation development of new chemical entities. Any…

tamarind seed powder in combination with HPMC, magnesium oxide, and talc. Tamarind seed powder is used for dissolution enhancer (improve dissolution). Method: Six Formulations were developed with varying concentration of polymer like HPMC and other excipients like tamarind seed powder, magnesium oxide and lactose. Result: The formulations were evaluated for hardness, thickness, surface pH, weight variation, content uniformity, and swelling index. The maximum in vitro drug profile was achieved…

(H2O: ACN, 90:10) using a 100ml volumetric flask. This mixture was placed on a sonicate bath for 15 minutes to allow for complete dissolution of the aspirin. Using a syringe driven filter device, the solution was filtered to get rid of the insoluble excipients like talc contained in the aspirin tablet. A pipette was used to transfer 0.2ml of the stock solution into six (6) different 10ml volumetric flasks. The volumetric flasks were labelled 1 to 6 accordingly. Standard Aspirin preparation:…

Mayenne France, this involved Identification, quantification and analysis of carrying Amoxicillin Trihydrate API and Sodium Benzoate in Amoxicillin Sugar Free antibiotics. 1.2 Scope Analytical Testing is carried to identify and quantify the API, excipients and related substances in a drug. Since most drugs are exhibit UV absorbances, HPLC with UV detection is commonly used in assays for…

Materials and Methods 4.1 Materials and equipments Table no. 4.1: Materials/Chemicals used in the project work S.No. Material/Chemicals Property Source 1. Tinidazole Pure drug Trozan Pharma 2. Guar gum Polymer Central drug house Pvt. Ltd. New Delhi 3. Starch Disintegrant Nice Chemicals 4. Micro crystalline cellulose Diluent, Disintegrant Loba Chemie, Mumbai,India 5. Talc Lubricant Nice Chemicals Pvt. Ltd. 6. Acetone Solvent Nice Chemicals Pvt. Ltd. 7. Potassium dihydrogen phosphate…

Preformulation Study Preparation of calibration curve of Amoxicillin trihydrate [51,53,76] Preparation of stock for Hydrochloric acid Stock solution in 0.1N Hydrochloric acid (0.1N HCl): 10 mg of Amoxicillin was accurately weighed and transferred into 10 ml volumetric flask. It was dissolved and diluted to volume make up to mark with 0.1N HCl to give stock solution containing 1000 µg/ml, after than 1ml take to from 1000 µg/ml and dilute to volume make up to mark of 10ml volumetric flask with…

1.0 INTRODUCTION: 1.1 Oral Drug Delivery System: Oral route is the most common route of drug administration. Modern drug delivery strategies try to improve oral drug delivery.1 When a new drug is discovered, a pharmaceutical industry asks one of the first questions is whether the drug can be effectively administered for its intended effect by the oral route or not. If patient self administration cannot be achieved, the sale of drug constitute only small fraction of what the market would be…

Mesalazine and Rifaximin use for Inflammatory Bowel Disease. Mesalazine is used as in anti-inflammatory agent, Steroidal. Rifaximin is used in Gastrointestinal Agents, Anti-infective agent. The use of Rifaximin in combination with Mesalazine has been proved to provide beneficial effect in inflammatory bowel disease. The mechanism of Mesalazine and Rifaximin is quite different. Mesalamine and Rifaximin are two different types of drugs offering some symptomatic relief to the IBD patients.…