Excipient

INTRODUCTION Oral Controlled Release Drug Delivery Systems1, 2: Oral controlled release drug delivery is a drug delivery system that provides*give the continuous oral delivery of drugs at predictable and reproducible kinetics for a predetermined period throughout the course of GI transit and also the system that target the delivery of a drug to a specific region within the GI tract for either local or systemic action. All the pharmaceutical products formulated for systemic delivery via*throw…

Two chromatographic methods were developed for the assay of the FDA approved lozenges containing dextromethorphan hydrobromide (DXT) and menthol (MNT). The first was a green HPTLC method which depends on using Merck HPTLC aluminum sheets of silica gel 60 F254 and methanol-ammonia (10:0.1, v/v) as mobile phase. This was followed by densitometric measurements of the spots which were retained at 0.28 ± 0.01 for DXT and 0.76 ± 0.02 for MNT scanned at 210 nm. The method was found linear over the…

4. Analysis of Traditional Chinese Medicines (TCM) [26] The identification and quantification of components of traditional TCM by chromatographic analysis (HPLC) is one of the major challenge. As TCM is a complex matrices in which all the constituents plays specific role for the overall efficacy. So the analysis of all the constituents synchronously is necessary to quality control the TCM. So the new technique UPLC is used for the quality control of the TCM. 5. Multi-residue analysis of…

Name: KOH WEI YING (A148456) Title: Reflective writing for HKL Visit 1) What you have learned from the visit. Firstly, I learned three ways of using nicotine-containing products which include smoking, chewing and sniffing with given examples for each. Besides that, I was amazed by the severe consequences as a passive smoker (exposure of >15mins twice weekly). I was taught that it is harder to quit smoking than to quit any other substance abuse like codeine or morphine. It is also important…

Everyone wants to lose weight but not everyone knows how to start the process. The good news is we have created a training plan designed to help individuals seeking to lose weight; kick start the process. If you follow the outlined plan; you can expect to lose ten pounds in thirty days. The plan focuses on diet, , supplements, exercise, tips and tricks and overall well-being. The training methods utilized to present plan materials include the standard lecture, team teaching, and…

1.1 General consideration Monitoring of different Clinical Research enables research ethics boards to ensure that, the standards that they approve in theory are being applied in practice [1] [2]. It has been suggested that such review has to be performed regularly and that it include monitoring of a variety of aspects of research, such as the consent process, adherence to the approved protocol and data integrity [1] [3]. 1. Weijer C, Shapiro S, Fuks A, Glass KC, Skrutkowska M. Monitoring…

parameters: Percentage yield: After complete drying, the drug loaded microparticle was collected and weighed accurately [9]. The yield of microparticle was calculated by: Percentage yield =( Total wt.of formulation (g))/( Total wt.of drug +Total wt.of excipient) X100 Surface Morphology [10]: The morphology of the microparticle was determined with the aid of Scanning Electron…

The concentration of CDCL and CSER is obtained by solving equation (1) and (2) CX = A1 / ax1 ………………..... (1) CY = [A2 – (ax2 × CX)] / ay2…...(2) Where,  A1 and A2are absorbance of mixture at λ1 and λ2respectively.  ax1 and ax2 are absorptivities of DCL at λ1 and λ2, respectively,  ay1 and ay2 are absorptivities of SER at λ1 and λ2, respectively,  CXandCYare concentrations of DCL and SER, respectively. Concentration of DCL and SER in the powder mixture is found by using equation (3) and (4)…

(Mascarenhas, 2003). For example, there are cases where an avoidable severe complication has been reported with the use of pancreatic enzymes after changing the product. It turns out this complication was a consequence of using of an enteric coated excipient (Peckham & Whitaker, 2013). Moreover, using acid suppression medication, such as proton pump inhibitors, may boost the effect…

To meet the ever increasing demands for improved quality of life, a number of pharmaceutical researchers have developed a variety of dosage forms and the oral route has always been the most preferred means of drug administration due to the ease, high patient compliance and low cost of production. In spite of a variety of dosage forms, tablets are most commonly adopted dosage form. The class II drugs have low solubility issues which results in poor dissolution rate and bioavailability[1,2].…