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  • Solifenacin Succinate Tablets Case Study

    Solifenacin succinate immediate release tablets. The study involves preformulation studies of drug excipients, formulation and processing development along with evaluation of tablets made with the optimized formulation. Finally tablets were evaluated by in-vitro methods. 6.1. Drug excipient compatibility study Table 1. Results of compatibility study S.No. Name of Excipient Ratio of API/ Excipient Initial description Final Description 400C/75%RH Conclusion 2ndweek…

    Words: 1564 - Pages: 7
  • Quality Control Case Study: Particles Deformation And Frormation

    Direct Compression: Suitable for formulation with high drug loading yet good flowability. Excipients and API are first blended in a intermediate bulk container. The blend is then fed directly to the tablet press. Segregation is often the main issue that needs to be addressed, due to: – drastic differences in the characteristics of the ingredients…

    Words: 992 - Pages: 4
  • Summary Of Ketorolac Tromethamine

    The invention relates to formulation of Ketorolac Tromethamine and Phenylephrine Hydrochloride immediate release tablet having less disintegration time. HPLC method was developed and validated for determination of content of Ketorolac Tromethamine and Phenylephrine Hydrochloride in immediate release tablet. UV spectrophotometric method was developed and validated to study drug release profile of Ketorolac Tromethamine and Phenylephrine Hydrochloride in immediate release tablet. Background:…

    Words: 854 - Pages: 4
  • Pre Formulation Study Essay

    Glycol-400 2.253 Propylene Glycol 20.52 Tween 80 9.653333 Buffer pH (6.8) 0.194 DRUG POLYMER INTERACTION STUDY: From the spectra of Efaverinz, combination of Efaverinz with excipient, it was observed that all characteristic peaks of Efaverinz were present in the combination spectrum, thus indicating compatibility of the drug and excipient. IR spectra are shown in Fig:…

    Words: 797 - Pages: 4
  • Raloxifene Hydrochloride Investigation Report

    R2 values of both the calibration plots were nearer to 1, which indicated that the methods developed were following Beer-Lambert’s law and could be used for further estimation. Analytical Interference Study of Raloxifene Hydrochloride with tablet excipients was done for assay and dissolution purposes, and no interference was observed at λmax of Raloxifene Hydrochloride. 10.1.2 Preformulation…

    Words: 876 - Pages: 4
  • Analysis Of Gemifloxacin Mesylate

    ANALYTICAL METHODS Determination of λ max Gemifloxacin mesylate λ max is determined by preparing one standard concentration of 10μg/ml and scanning should be done. Preparation of 0.1N HCL 8 ml of hydrochloric acid is taken in 1000ml volumetric flask and dissolved with distilled water and then make up to 1000ml with distilled water. Standard graph of Gemifloxacin mesylate: The λmax of Gemifloxacin mesylate in 0.1N HCL was scanned in UV-Visible Spectrophotometer and found to have maximum…

    Words: 1000 - Pages: 4
  • Pharmaceutical Tablets Essay

    which allows the tablet to be sufficiently large for consumption and provides sufficient surface properties of the particles within the mixture to facilitate suitable agglomeration for proper mixing and tableting, these ingredients are known as excipients. Tablets used for medication often require a precise quantity of API and as such, an evenly distributed or ‘homogenous’ mix throughout the stages of…

    Words: 2048 - Pages: 9
  • Barbiturates Research Paper

    2). HEROIN: Heroin is formed by conversion of morphine which does not require complex equipmentation but more elaborate chemical operation under which morphine is refluxed with acetic anhydride for about 5 hours results into the formation of Diacetyl morphine, i.e., heroin. It is seperated when the solution gets neutralize with sodium carbonate or washing soda in which heroin gets separated as a precipitate. It is collected and purified by treating it with hydrochloric acid by which Heroin…

    Words: 1658 - Pages: 7
  • Dynamic Risk Assessment Definition

    applied drug development, manufacturing, distribution, inspection, and submission/review processes throughout the lifecycle of drug substances, drug products, biological and biotechnological products including the use of raw materials, solvents, excipients, packaging and labeling materials in drug products, biological and biotechnological products.Quality risk management is a systematic…

    Words: 770 - Pages: 4
  • Analysis Of Rf Value Of Caffeine

    The mixture is also sonicated to further assist the increase in rate of reaction. The solid portion of the slurry is insoluble in ethyl acetate which is the excipients of the tablets therefore didn’t dissolve due to its polarity. The solid portion was filtered using filter paper into a seperating…

    Words: 765 - Pages: 4
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