Excipient

    Page 3 of 6 - About 55 Essays
  • Good Laboratory Practice

    In the drug development procedure, Good Laboratory Practice stand at the Preclinical Development Stage, also called as a non-clinical stage as it is not conducted in human. Its main goal is to test the safety. Toxicology, Pharmacokinetics Pharmacodynamics and bioavailability studies must follow the GLP compliance.Good laboratory practice (GLP) was first announced in New Zealand and Denmark in the year 1972 and later in the USA in June, 1979 as regulations passed to stop investigators who submit…

    Words: 820 - Pages: 4
  • Lornoxicam Research Paper

    OBJECTIVE: To deliver lornoxicam into systemic circulation by engineering ethosomal gel formulation. RATIONAL OF WORK: Because of their improved pervasion of medication through skin.  lornoxicam is BCS class II medication causes gastric bothering when managed orally  ethosomes are stages for the conveyance of vast and differing gathering of medications.  due to their generally safe profile.  better understanding agreeability can be utilized as a part of the manifestation of gel,…

    Words: 864 - Pages: 4
  • Isomeric Purity Essay

    (section 2.4). Then it was chromatographed under the same conditions described in section 2.2. The chromatogram of placebo was compared with that of the sample tablet (Fig. 5a) and standard drugs solutions. No interfering substances due to formulation excipients were eluted or interfered at the retention times of the drugs. Moreover, the DAD confirms the peak purity by recording the purity profiles and comparing the recorded plots of the sample tablet (Figs. 5b & 5c) with the…

    Words: 769 - Pages: 4
  • Solubility And Bioavailability Of Ginkgo Biloba Extract

    Wang et al. (2015) formulated a solid dispersion to improve the solubility and bioavailability of Ginkgo biloba extract (GE) through hot melt technology. The polymer studied were Kollidon® VA64/Kolliphor® RH40 (85:15) and the extrusion was carried out at 120-125⁰C with 100 RPM with 25% drug load. DSC and XRD studies confirmed the amorphous conversion of the GE and the dissolution carried in 250ml of 0.1N HCl showed that the dissolution of solid dispersion of GE was significantly improved (2-3…

    Words: 876 - Pages: 4
  • Biopharmaceutical Classification System Case Study

    Introduction When a particular medicine is swallowed (tablets, capsules, etc). The absorption or uptake of the drug into the body mainly depend on two factors. 1. How well does the drug dissolves in stomach and gastrointestinal(GI) fluids (solubility of drug) 2. How readily does the drug passes through the intestinal wall into the blood (drug permeability) To find out how a drug is likely to be taken up when it is swallowed. The Biopharmaceutical Classification System (BCS) was introduced by…

    Words: 992 - Pages: 4
  • Oxybutynin Research Paper

    Oxybutynin Chemical structure Mode of action and pharmacology Oxybutynin is an antimuscarinic, antispasmodic medicine that is used to relieve urinary symptoms caused by an overactive bladder. An over active bladder is caused by involuntary contractions of the detrusor muscle surrounding the bladder causing it to empty unnecessarily. The detrusor muscle helps control normal working functions by relaxing and contracting as the bladder fills and empties. Symptoms include…

    Words: 921 - Pages: 4
  • Oral Controlled Release Essay

    INTRODUCTION Oral Controlled Release Drug Delivery Systems1, 2: Oral controlled release drug delivery is a drug delivery system that provides*give the continuous oral delivery of drugs at predictable and reproducible kinetics for a predetermined period throughout the course of GI transit and also the system that target the delivery of a drug to a specific region within the GI tract for either local or systemic action. All the pharmaceutical products formulated for systemic delivery via*throw…

    Words: 7242 - Pages: 29
  • Amlodipine: A Case Study

    1. Amlodipine is a medication used to lower blood pressure and prevent chest pain. It belongs to a group of medications known as long acting dihydropyridine-type calcium channel blockers. Amlodipine widen the blood vessels and improves blood flow. Widening of these blood vessels lowers blood pressure. In angina, amlodipine increases blood flow to the heart muscle to relieve pain due to angina. (WHO, 2013). Amlodipine was discovered by a research team lead by Simon Campbell and created by the…

    Words: 2183 - Pages: 9
  • Gas Chromatography Method

    Two chromatographic methods were developed for the assay of the FDA approved lozenges containing dextromethorphan hydrobromide (DXT) and menthol (MNT). The first was a green HPTLC method which depends on using Merck HPTLC aluminum sheets of silica gel 60 F254 and methanol-ammonia (10:0.1, v/v) as mobile phase. This was followed by densitometric measurements of the spots which were retained at 0.28 ± 0.01 for DXT and 0.76 ± 0.02 for MNT scanned at 210 nm. The method was found linear over the…

    Words: 945 - Pages: 4
  • Methadone Replacement Therapy Reflection Paper

    Name: KOH WEI YING (A148456) Title: Reflective writing for HKL Visit 1) What you have learned from the visit. Firstly, I learned three ways of using nicotine-containing products which include smoking, chewing and sniffing with given examples for each. Besides that, I was amazed by the severe consequences as a passive smoker (exposure of >15mins twice weekly). I was taught that it is harder to quit smoking than to quit any other substance abuse like codeine or morphine. It is also important…

    Words: 1232 - Pages: 5
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