Platelet

wide inter-individual variations. Various studies have shown that the polymorphisms in the genes responsible for Clopidogrel absorption and metabolism are a major factor for these variations. Polymorphisms in the CYP2C19 and P2Y12 gene affect the platelet aggregometry response to Clopidogrel. This increases the risk of recurrent thrombotic events in patients who are poor responders to clopidogrel. Hence it is important to determine the relationship between these polymorphism…

WISKOTT –ALDRICH SYNDROME PRESENTING WITH JMML LIKE BLOOD PICTURE AND NORMAL SIZED PLATELETS Abstract Objective. The aim of this paper is to report the case of Wiskott Aldrich syndrome ( WAS) patient presented with unusual laboratory features . Clinical Presentation and Intervention. Male neonate admitted with symptoms related to thrombocytopenia,whose initial diagnosis were considered as neonatal alloimmune thrombocytopenia and JMML (Juvenile myelomonocytic leukemia) but subsequently…

that thrombocytopenia is caused by a low platelet (Thrombocyte) count which would result in a bodies hindered ability to perform important blood clotting functions [2]. Most of the time the symptoms aren’t life threatening and in mild cases the person suffering from the disorder doesn't even experience any related symptoms [3]. In severe cases, this disorder can cause uncontrollable bleeding on the brain which ultimately leads to death [2]. The lower the platelet count gets the more dangerous…

TITLE PLATELET RICH FIBRIN USED IN THE REGENERATION OF INTRAOSSEOUS DEFECT IN AGGRESSIVE PERIODONTITIS PATIENT – A CASE REPORT ABSTRACT (Words: 127) Background: Platelet rich fibrin (PRF) is a fibrin matrix made of platelets, cytokines and growth factors. It releases growth factors essential for regeneration for healing. Case Report: PRF was obtained by a simple process from a generalized aggressive patient. PRF obtained was placed in the…

mitochondrial mediated apoptosis 6-7. Platelets express several distinctive apoptotic signs during storage 8-10. PS exposure is also a characteristic of apoptosis and appears to be a mechanism by which apoptotic cells are recognized and…

addition to being part of the hemostatic process, platelets have been increasingly recognized as an important component of the immune response to infection (Katz et al., 2011). Platelets are important inflammatory cells that can undergo chemotaxis and are able to release numerous proinflammatory molecules (Elzey et al., 2005). Thrombocytopenia is a recognized marker of poor outcome in patients with pneumonia, due to the association of low platelet counts with severe intravascular…

life through the medicines that are accessible. In 1958, cancer specialist Dr. Bertha Bouroncle was the first to distinguish a dangerous malady now known as bristly cell leukemia. Leukemia is a cancer of the platelets and it shapes when typical platelets change and become wildly. Platelets are made in the bone marrow, the elastic…

dermatology and hair loss on diverse range of types of skin. Vampire facial Vampire face lift is a procedure that entails withdrawal of a patient’s blood, processing it to get “platelet –rich plasma” then injecting it back to erase wrinkles giving one a more youthful appearance. The rationale behind use of platelets; platelets contain a myriad of growth factors that stimulate the synthesis of collagen, cell growth, skin renewal and ultimately regeneration of tissue. One of the benefits of the…

inflammation and asthma for chronic inflammation. A2: Platelets are…

Theoretical/Conceptual Paradigm The study is based on the premise that various preparations of platelet concentrate such as PRF and CGF may be regarded as healing biomaterials since they contain all the necessary components permitting optimal wound healing following surgical procedures. Components such as growth factors and pro-inflammatory cytokines have been reported to work in unison for the achievement of wound healing in various medical and surgical cases. As such this can be a…