Platelet

significant change to the platelet count that has been established to be 10 µM. Such was confirmed by the flow cytometry that exhibited the highest increment in larger platelets, with increase ranging between 10 and 20 µM of ADP. However, 20 µM could not be used because it would cause excessive aggregation. Platelets contained in population 1 (P1) area are all of the same size as that of the resting platelets and they are assumed not to be activated. Whereas, the platelets in population 2 (P2) area tend to be bigger. It is assumed that they are activated. As more agonists are added, the percentage of larger platelets increases. Such is likely to arise because as the platelets grow bigger, the more they scatter forward and sideways. In a graph showing change in size, it is possible for flow cytometer to detect a shift that takes place in the size of the platelets. The platelet aggregation testing aim at measuring the…

cultures should be obtained as soon as possible after the initial onset of fever. A complete blood count with differential (CBC) provides healthcare professionals with information about the kinds and numbers of cells in the blood, including red blood cells, white blood cells, platelet levels, and hemoglobin and hematocrit (WebMD, 2016). Not only does a CBC provide information regarding the different blood cells, but physicians utilize the information to diagnose many health issues such as…

Among Jews of Ashkenazi (Eastern European) descent, the incidence is higher: up to 1 in 850 people. The higher frequency of Gaucher disease among this population has led to the misconception that Gaucher disease is a "Jewish genetic disease,” but in fact, individuals of any ethnic or racial background may be affected (Gaucher Care 1). As you can see, the gender that is most affected with this disease is the Jewish population. From there, it can spread to other groups of people. There are three…

“A Novel Application of Microfluidic Assay to Evaluate the Role of Calponin in Platelet Function and Clot Formation” Introduction: Platelets are a very important aspect of blood clotting. They are also essential in the evolution of clots in Coronary and Cerebral arteries, which cause heart attacks and strokes, respectively. Every year, 610,000 people die of heart disease in the United States; this is 1 in every 4 deaths. Cardiovascular disease is the number one cause of death in the United…

The patient with platelet dysfunction also may present with petechiae (small capillary hemorrhage), ecchymoses (small purple, multiple superficial lesions), purpura, epistaxis, hematuria, bleeding gums, menorrhagia ( heavy menstrual blood flow) and metrorrhagia ( bleeding between period). On the other hand, a patient with coagulation problem may have delayed bleeding issues. Bleeding from minor trauma or spontaneous bleeding can be persistent. The patient may present with palpable large…

pre-operative patient I was able to assist with was 77 year old, R.W, a white female in for a sonography. Ms. R.W. was receiving a sonography because she had a wound underneath her stomach that will open and gush blood at random times and then close back up. The sonography was going to try and determine what might be causing the wound to open. A sonography is a diagnostic procedure that visualizes body tissue structures or wave-form analysis. This ultrasound can detect tissue abnormalities such…

analysis being undertaken within the first four hours after phlebotomy, whether tripotassium EDTA or dipotassium EDTA are used would not have significance variation on the results obtained from the differential analysis of white blood cells and full blood cell counts (Macey et al. 2002). Furthermore, citrate is also applicable as an anticoagulant especially in coagulation tests. This is because, different from EDTA, the activation of platelets in vitro tends to be less spontaneous when using…

Critique of Systematic Reviews Two systematic review articles will be critiqued and compared in this paper. Article A is titled systematic review and meta-analysis of adverse events of low-dose aspirin and clopidogrel in randomized controlled trials authored by Kenneth McQuaid and Loren Laine. Article B is titled platelet function testing in transient ischemic attack and ischemic stroke: a comprehensive systematic review of the literature by Soon Lim, Catherine Coughlan, Stephen Murphy, Israel…

According to the Center for Disease Control and Prevention, Hemophilia affects 1 in 5,000 male births which factor out to be about 400 babies born with hemophilia each year [3]. Hemophilia is classified as one of the oldest and longest lifelong bleeding disorders that are inherited, meaning passed down from parents to their children. This disorder occurs when the protein in the blood or platelets that assists the blood to clot is absent or not functioning properly, resulting in extended…

Two days later, she stopped breathing and I popped her diaper and she began to cry. I immediately call her pediatrician and he told me to bring her in. He ran all kinds of test and found nothing. Not being pleased with his effort he admitted her into the hospital for even more test. That hospital transferred her to Lebonour Children’s Hospital an hour and a half away. They found out that her white platelets in her blood were severely low and she needed a blood platelet transfusion immediately.…