Community-acquired pneumonia (CAP) is defined as an acute infection of the pulmonary parenchyma in a patient who has acquired the infection in the community. CAP is a common and potentially serious illness. It is associated with considerable morbidity and mortality, particularly in elderly patients and those with significant comorbidities (Thomas et al., 2013).
In addition to being part of the hemostatic process, platelets have been increasingly recognized as an important component of the immune response to infection (Katz et al., 2011). Platelets are important inflammatory cells that can undergo chemotaxis and are able to release numerous proinflammatory molecules (Elzey et al., 2005).
Thrombocytopenia is a recognized marker of poor outcome in patients with pneumonia, due to the association of low platelet counts with severe intravascular coagulation and severe sepsis. (Mandell et al., 2007). Conversely, thrombocytosis has often been considered a sign of normal inflammatory reaction, but not as a marker of poor outcome. The clinical profile, inflammatory biomarkers, and mortality in patients with CAP may be different in those presenting with thrombocytosis and thrombocytopenia than in patients with normal platelet …show more content…
There are many criteria & markers of it’s severity & outcome. Platelet count can be used as a simple method in prediction of morbidity & mortality so the management of CAP can be adjusted accordingly to provide the patients a better outcome.
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RESEARCH QUESTION
What is the value of platelet count of hospitalized patients with CAP by using platelet count as an additional criteria to design the management of CAP predicting morbidity & mortality of these patients ? .
AIM OF THE WORK To improve the outcome of hospitalized patients with CAP by using platelet count as an additional criteria to design the management of
In addition to being part of the hemostatic process, platelets have been increasingly recognized as an important component of the immune response to infection (Katz et al., 2011). Platelets are important inflammatory cells that can undergo chemotaxis and are able to release numerous proinflammatory molecules (Elzey et al., 2005).
Thrombocytopenia is a recognized marker of poor outcome in patients with pneumonia, due to the association of low platelet counts with severe intravascular coagulation and severe sepsis. (Mandell et al., 2007). Conversely, thrombocytosis has often been considered a sign of normal inflammatory reaction, but not as a marker of poor outcome. The clinical profile, inflammatory biomarkers, and mortality in patients with CAP may be different in those presenting with thrombocytosis and thrombocytopenia than in patients with normal platelet …show more content…
There are many criteria & markers of it’s severity & outcome. Platelet count can be used as a simple method in prediction of morbidity & mortality so the management of CAP can be adjusted accordingly to provide the patients a better outcome.
.
RESEARCH QUESTION
What is the value of platelet count of hospitalized patients with CAP by using platelet count as an additional criteria to design the management of CAP predicting morbidity & mortality of these patients ? .
AIM OF THE WORK To improve the outcome of hospitalized patients with CAP by using platelet count as an additional criteria to design the management of