DNA repair

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  • DNA Damage And Repair In Vascular Disease

    For example, (alcohol flush reaction) around 50% of Asian people with genetic variation in Aldehyde dehydrogenase (ALDH), alcohol metabolizing enzyme. They eliminate alcohol at a slower rate. This variation may keep them away from becoming alcoholic. Based on the review PAPER 12: "DNA Damage and Repair in Vascular Disease" Annu. Rev. Physiol. (2016) 78:5.1-5.22, Respond succinctly and clearly the following three questions: 4. What do the Authors mean when stating "It is often unclear whether DNA damage directly contributes to the disease or is an innocent bystander that is generated by the same stimuli that result in disease but is not causal." Explain using your own words while justifying your response by providing examples The author here tries to say the cause of DNA damage in vascular diseases is still obscure. Different DNA damage stimulates due to endogenous (e.g. ROS) or exogenous stimuli (e.g. Chemotherapy). So, is the DNA damage cause the vascular disease or is the same stimuli (inflammation or risk factors) indirectly causing DNA damage causing vascular diseases.…

    Words: 1079 - Pages: 5
  • The Health Benefits Of Stem Cells

    “Regenerative medicine holds promise for the treatment of degenerative and genetic diseases” (Marini, 2012, pg 2522). They serve as an internal repair system and divide without limit to replenish other cells. They are different than normal cells in two ways. Firstly, they are unspecialized cells that care able to renew themselves though cell division after long periods of inactivity. Secondly, in some conditions they can be induced to become tissue or organ specific cells with certain special…

    Words: 1784 - Pages: 8
  • Colorectal Cancer Essay

    For example, a high consumption of red meat has been shown to result in an increased risk of colorectal cancer while certain types of fibres (i.e. fruit fibre) could reduce the chances of colorectal cancer. Furthermore, more recent research has linked the impact that food composition patterns on colorectal cancer to gut microbiota composition. It has been shown that microbiota play an important role in colorectal cancer etiology by influencing inflammation, DNA damage and cell death (Louis,…

    Words: 863 - Pages: 4
  • Brca1 And Brca2 Genetic Testing, Should Everyone Do It?

    is observed that three essential domains are affected the most from a harmful mutation in BRCA1: the N-terminal at RING domain, the coding region of exon 11-13 and the C-terminal coding exon 16-24. 8 The carboxyl terminus contains a BRCT domain. BRCT domains have a role in coding proteins that are involved in cell cycle checkpoints. BRCA1 is in contact with P53 from its BRCT domain and functions in DNA damage repair.8 Furthermore, BRCA1 is a gene that codes for the BRCA1 protein in the body.…

    Words: 3159 - Pages: 13
  • Xeroderma Pigmentosum Research Paper

    recessive alleles are present in an individual from their parents. This disease impairs the ability of the body to repair DNA which is damaged mainly by Ultraviolent light as well as various chemical Carcinogens. ” The most common forms of DNA damage occurs via the cross linking of adjacent pyrimidines resulting in the formation of cyclobutane pyrimidine dimers (CPDs)” (1) for example UV light will often make two T 's bases next to each other bind making a dimer. The regions of the cells…

    Words: 1485 - Pages: 6
  • Formaldehyde And Its Effect On Formaldehyde

    2014). The mechanisms by which formaldehyde produces its carcinogenic affects and the mechanism by which the cell repairs these aberrations inflicted on DNA is not know. This paper will focus on formaldehyde’s abundance in the surrounding environment, as well as the ways formaldehyde interacts with DNA to induce DNA damage. This paper will also briefly talk about some plausible mechanisms of DNA repair the cell…

    Words: 1858 - Pages: 8
  • Cancer Development Research Paper

    on epidemiological studies, 5% to 10% of cancers resulting from gene mutations are inherited from parents. These are the reasons why some cancers occur to a certain group of people. Cancer is a disease that certain cells with abnormal genetic function reduplicate without control or order. Genes are located on chromosomes, which are composed by deoxyribonucleic acid (DNA), and could be inherited and mutated. They provide the instructions for cells to translate and to transcribe the codes to make…

    Words: 1323 - Pages: 6
  • Synthesis Essay On Tobacco

    tobacco and exposure to other carcinogens increases human risk for cancer significantly by enhancing DNA mutation rates. Different carcinogens cause slightly different types of DNA damage in humans that eventually lead to cancer (Ehrenberg, 2016). These unique patterns of mutations that occur in different types of cancer tissue are what makes each carcinogenic mutation unique and leave behind their own mutational signature on the cancer genome. These signatures can be used as a physiological…

    Words: 1544 - Pages: 7
  • Genetic Mutation

    Most people think mutation is a bad thing, but it can be beneficial to human because it creates genetic variations and survival advantage. Mutation is a process that changes the DNA sequence. It has been studies that multiple genes are the possible risk factors for breast cancer. However, mutation of the genes relates to breast cancer because it is a result of critical genes growing and dividing uncontrollably, which are responsible for cell growth and repair damaged. According to Genetic…

    Words: 1003 - Pages: 4
  • The Effects Of Lead In The Body

    It was also observed that lead exposure can trigger caspase-3*5, a protease that is highly reserved across mammalian species and is associated with programmed cell death. it is also a factor in the release of cytochrome C in the mitochondrial pathway*5. At Low concentrations lead has been shown to activate cellular growth mechanisms. In theory lead mobilizes free calcium ions and activates protein kinase C. This movement triggers a cascading event leading to the end product of DNA synthesis. In…

    Words: 1364 - Pages: 5
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