Gene

is cystic fibrosis (CF), which causes the lungs to be clogged up by a thick, sticky mucus. This may also lead to infections and blockage of the pancreas (National Human Genome Research Institute). The Cystic Fibrosis Transmembrane Regulator (CFTR) gene causes this genetic disorder and was discovered in 1989. Roughly 30,000 people are affected by this genetic disorder in the U.S. and while there is a lot of promising research, a cure is yet to be discovered (National Human Genome Research…

It’s important to realize that each scientific break through is made possible by the work that came before it. It’s a lot like putting puzzle pieces together, collecting different important evidence until enough puzzle pieces result in another break through. Fifty years ago two scientists announced to a lunch time crowd that they had discovered the secret to life. How DNA changed the world To begin with scientists used to have no understanding of what caused distinct patterns of inheritance.…

potential of TGF-b1 in promoting the healing process of injured skin, increasing the collagen deposition and improving the tensile strength of skin wounds. Moreover, studies of transgenic and gene knockout mice provided an in depth information about the role of TGF-b1 in skin regeneration. It is confirmed that gene silencing of Smad3, as a key signaling pathway for regulating the activity of TGF-b, with siRNA could induce the skin…

valuable for determining the purposes and operations of genes that have not been sufficiently studied in the laboratory. These genes are replaced with mutant or diseased versions of themselves, permitting researchers to discover and discern how losing the normal function of certain genes can affect an organism. Through the use of this technology, the mouse genome has been extensively mapped and attributed to a variety of functions for specific genes. In this analysis, I will discuss knockout…

stuff happen). Furthermore, this technology would be disastrous in the wrong hands. If this technology were to be widely available to any so called “scientist” with a lab in his garage, there would be a huge risk for someone messing with the wrong genes in anything and accidentally creating a disease to cause the next plague, and, thanks to China, CRISPR-Cas9 kits are now available for just $130 (source). Plus, there would be nothing to stop dictators, such as the one in North Korea, from…

This paper explores four published articles and four internet websites pertaining to Phenylketonuria. In this paper Phenylketonuria causative mutations, signs and symptoms along with treatment and long term prognosis are discussed to help individuals better understand Phenylketonuria and its effects on our population. Increasing public awareness towards Phenylketonuria can help lead to further research in hopes of medical advancements and encourage newborn screening in under developed countries.…

PDAC biomarker identification and validation. Biomarkers in ex vivo expanded CTCs will be recognized by stringent statistical analysis and subjected to further characterization in three studies. First, we will confirm the association of biomarkers with CTCs and CTC-PDX models. Second, the biomarkers will be validated for correlation with clinical PDAC metastasis and therapeutic resistance. Finally, we will retrospectively test the application of selected biomarkers in PDAC diagnosis, treatment…

laws of heredity that still hold true today for all organisms. Mendel 's discoveries about genes are not recognized by other scientists for over thirty five years. In 1910 the Chromosomal theory of inheritance was proposed and Thomas Hunt Morgan established that genes are found on chromosomes by physically finding an exact gene to an exact chromosome. In 1941 George Beadle and Edward Tatum establish that one gene creates one enzyme or protein, and shared the 1958 Nobel Prize in Medicine. Then in…

patient during all stages of care, including prevention, diagnosis, treatment, and follow-up”. This new way of tailoring medicine would help in study, identification, analysis and diagnosis of any disease caused due to certain mutations in patient’s gene and treatment would be done accordingly to target that specific mutation. The proliferation of bioinformatics and computational genomics plays a pivotal role in making this incentive effective. From extracting the raw data of DNA to…

HGPS Collins and his team of researchers decided to screen 23 affected individuals for mutations of the Lmna gene. They chose the Lmna gene due to its involvement in a wide spectrum of heritable disorders including Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, and Charcot-Marie-Tooth disease (“Lmna”). The decision to screen the Lmna gene definitely paid off, as three different mutations were discovered. The mutations encompassed the…