Bioinformatics

The aCGH assay will be an essential tool to assess the genomic changes. Based on the results of SKY and aCGH analyses, representative CTC cultures will be subjected to mutation screening in CTC, CTD-PDX and biopsy materials by whole genome sequencing using NGS for comprehensive molecular profiling of abnormalities at the nucleotide level. NGS data will be transferred to Palanisamy, who will carry out biostatistics and bioinformatics analysis. Given the unbiased nature of NGS analysis, we anticipate identifying new druggable genomic mutations on a personalized…

It is in the 21st century that the world has witnessed significant developments in technology. World class information and technology systems have also been created to enhance and facilitate the need that comes with development in technology. Most of these developments have been made possible by the availability of the internet (Amoroso, 2011). The internet has been able to link every corner of this world into one big family. Any person can obtain, upload and share information among other…

Bioinformatics is a study that focuses on the collection and analysis of biological information using information from sequences of DNA, RNA, and proteins. This field focuses on how to make predictions about biological systems and analyze data to provide more insight on how living organisms function and how its genome relates to its biology. Following the determination of the insulin sequence, Frederick Sanger realized that manually comparing several sequences was impractical (Moody 2004)).…

Northwest Nazarene University. Inspired by the work done on the Human Microbiome Project, this endeavor sought to predict bacterial behavior using its DNA sequence. As this project was in its infancy, most of my research was focused into generating a workflow that could be used for this process, and scouring through literature for examples of laboratories that had done the same. This bioinformatics project came to life in the second summer. Through a collaboration with the University of Idaho,…

Assignment-3: CS696 Programming Problems in Bioinformatics. Describe and discuss different approaches for finding motif in genetic string. Introduction: DNA, RNA and Proteins, these are three types of very large molecules essential for every living organism, for their biological functioning. Each molecule, DNA, RNA and Protein, play a vital role in living organisms, without them no life could survive. Let’s understand functionality one by one: • DNA consists of encoded instructions which are…

face. This particular face that I have remember seeing since my freshman year in college turns out to be my professor in the future. His name, Dr. Mark Pauley. Dr. Mark Pauley is my current Bioinformatics teacher, but that was not the first time I have seen. University of Nebraska, Omaha (UNO) is a fairly small campus so students get to see their professor around campus. I first met Dr. Pauley at UNO gym. I am certain he does not remember this. I was a tiny new college student and newbie in the…

We were told to interview a professional in our fields, someone who we could trust and has a profession relevant to our career path. This activity was important to me because I learned more about fields that I thought about going into. You get to ask a professional questions that you have always wonder and get a honest answer right from the source. I interviewed a Bioinformatics’ professional at The University of North Carolina at Charlotte. At that time, I was torn between following a career…

The data can be accessed from any part of the world and can be used according to the need. We can also say that certain class groups have benefitted by bioinformatics. Moreover, two articles summarized above have stated that in present the health records of every patient is stored in one place and physicians can access it give appropriate treatment to the patients. This has lead to having data in more organized and systematic manner. In addition, data’s should have a standardized language so…

the microbiome, autoantibodies and epigenome (Topol, 2014, p. 241). This information can now give rise to the exceptional and unparalleled opportunity to improve medical treatment for those with cancer and develop the preventative strategies required to maintain health (Topol, 2014, p. 241). Topol (2014, p. 248) states that the current classification of cancer, based upon the organ of origin should now be considered unsuitable and inadequate. This is due to the knowledge of the driving…

coli and a mutated plasmid. This lab group got mutation 1. The groups then used a program called Putty to view the bioinformatics program Muscle. Through Putty, each plasmid's DNA was sequenced to the base pair nucleotide letters. This enabled the groups to view the discrepancies between the genetic codes. Putty was opened on lab computers on the first day of this lab. Next, the group used Putty to input potential restriction enzymes to see where they would cut the DNA, and how long each of…