Ischemia

This is a gradual and progressive condition that is rarely caused by an infection (Greenfield 2015). Tissue ischemia may form coagulative necrosis, which is a sign for dry gangrene versus a liquefactive necrosis that indicates wet gangrene. The affected area becomes dry, cold, and eventually turns purple or black due to a lack of blood flow to that part of the body (Goodman 2015). Dry gangrene typically affects the distal extremities, thus it is usually seen at the patient’s fingers or toes. Our patient presented with dry gangrene located at his big toe on his left…

LITERATURE REVIEW Stroke is one of the major health problems worldwide and a leading cause of disability. But the treatment options for the management of stroke are limited. Thrombolytic reperfusion with recombinant tissue plasminogen activator (t-PA) is employed in acute phase in only less than 3% of all ischemic stroke patients while standard treatments involving rehabilitation provide some benefits for the recovery during chronic phase. However, many high-profile failures in a…

Asia is a vast and multicultural continent with an overall population of 4.3 billion people, taking up about 30% of the earth 's land. Among the 48 countries we chose Thailand, it is a country with multi economical background that we felt would be educational to study as a whole. Thailand is located in the south-eastern part of Asia with a population of 67.01 million. Approximately 65.7% of its population resides in rural areas (World Bank, 2014). It is considered an upper middle class income…

The article, Frequent sauna use may reduce risk of Dementia, written by Christopher Bergland, displays the studies that he found while researching the different lengths of time spent in the sauna to help lower the chance of gaining dementia/ Alzheimer's. During this study, experimentalists were to split into three different groups each given specific instructions on how long to stay in the sauna. The three groups were divided into different categories such as: one group were to maintain a…

Main Question Post: Week 4: Cardiovascular Disorders Myocardial Ischemia and Acute Coronary Syndrome Cardiovascular disease (CVD) persists as the principle source of death amongst the men and women globally, and has claimed further breathes yearly in the United States (U.S) than “cancer, chronic lung disease, and accidents” collectively (Dunlay, & Roger, 2012). Myocardial ischemia and acute coronary syndrome originate with the coronary artery disease. According to Huether and McCance (2012),…

Ischemia is a state of tissue oxygen deprivation accompanied by a reduced washout of the resulting metabolites (1). Reperfusion is the restoration of blood flow to the ischemic tissue. Despite the unequivocal benefit of reperfusion of blood to an ischemic tissue, reperfusion itself can elicit a cascade of harmful reactions that injure tissue(2). Studies have shown that renal ischemia - reperfusion injury in addition to kidney tissue, will also be affected distant organs such as the brain (3),…

Introduction: Upper limb ischemia presenting in the neonatal period is exceedingly rare1. Limb ischemia occurring in utero has three main causes: thrombosis, embolism, and in utero compression2. Neonatal arterial thrombosis and embolism are serious conditions that often result in high morbidity and mortality.3,4 Approximately 90% of neonatal arterial thromboembolic (TE) events are linked to iatragenic causes, including catheterization.4,5 TE events occurring in utero are especially rare, and can…

FFR is a well-validated clinical tool, used to assess the functional significance of intermediate or ambiguous coronary artery stenosis(1). Due to the advantages of hemodynamic assessment and guided coronary revascularization of culprit lesions FFR is considered as a gold standard technique for the evaluation of coronary stenosis provoking ischemia(2). Although FFR was originally described in the 1990s(3-5), it has become a clinical interest recently as various landmark studies proved its…

Critical limb ischemia (CLI) is a dangerous condition with a high mortality rate, potential socio-economic loss, and risk of amputation, especially in people with diabetes (1–4). Surgical bypass grafting has long been considered the gold standard of revascularization for lesions that are below the knee (BTK) (5). Percutaneous translumi- nal angioplasty (PTA) also improves limb perfusion; however, current treatment options are far from opti- mal even if this endovascular approach is the…

Subplate neurons are one of the earliest formed neurons in the cerebral cortex and play a critical role in cortical development and maturation. Specifically, they receive information from the thalamus and project unto the developing cortical plate. The cortex is comprised of a six-layers and subplate neurons are found in the developing white matter below layer 6. During critical periods, these neurons are necessary for the arrangement and improvement of thalamocortical connections. Subplate…