Stroke Recovery

Best Essays

Stroke is one of the major health problems worldwide and a leading cause of disability. But the treatment options for the management of stroke are limited. Thrombolytic reperfusion with recombinant tissue plasminogen activator (t-PA) is employed in acute phase in only less than 3% of all ischemic stroke patients while standard treatments involving rehabilitation provide some benefits for the recovery during chronic phase. However, many high-profile failures in a wide spectrum of pharmacologic neuroprotection trials have led to some pessimism in the field.[1] Recent findings suggest that enhancement of angiogenesis after focal cerebral ischemia may provide novel opportunities for better outcomes during stroke recovery.[2] Nowadays it is appreciated that new treatment strategies should target cerebral blood vessels and induction of angiogenesis will stimulate recovery processes including neurogenesis, synaptogenesis, and neuronal and synaptic
…show more content…
Some of the major factors are vascular endothelial growth factor (VEGF), Fibroblast growth factor-2 (FGF-2/bFGF), Platelet-Derived growth factor-Beta (PDGF-beta), Transforming growth factor-beta (TGF-beta). These angiogenic peptides are found to be upregulated following ischemic insults to promote micro vessel formation and brain remodeling.[1] Among these numerous endogenous angiogenic regulators, VEGF is the prototypical and most studied proangiogenic mediator in stroke.[2, 3] VEGF is an endothelial cell-specific mitogen which also plays a role in the regulation of vascular permeability. VEGF executes its biological effect through two tyrosine kinase receptors, Flt-1 (VEGFr-1) and KDR (VEGFR-2).[15] It has been known to be the potent mediator of neurorestoration following stroke by promoting neurogenesis and

Related Documents

  • Good Essays

    Stroke Recovery Paper

    • 871 Words
    • 4 Pages

    us about Stroke Recovery According to the World Health Organisation (2004) stroke is the second most common cause of adult mortality and the third most common cause of chronic disabilities in adults. Di Pino, Pellegrin, Assenza and Copone et al (2014) discussed stroke affects to the blood-oxygen supply to the brain disrupted synaptic transmission, observed as the lack of electrical activity in the penumbra after the stroke. More research has focused on how the rehabilitation of of stroke can be better…

    • 871 Words
    • 4 Pages
    Good Essays
  • Amazing Essays

    Stroke Recovery Essay

    • 2457 Words
    • 10 Pages

    death, one of which is strokes. Strokes, although not the leading cause of death, are still in the top ten causes; in fact, they are the fifth leading cause of death. Over one hundred thousand people die from strokes; however, not all stroke victims suffer from death. There are over 700,000 people who suffer from a stroke in the US, and although a great percent survives the initial stroke, as time goes on stroke victims risks of death increases. The chance that a stroke victim must have to do…

    • 2457 Words
    • 10 Pages
    Amazing Essays
  • Decent Essays

    Stroke recovery exercises are very important done by sufferers of stroke due to the generally although it has been stated to have been cured, but there are several limbs such as the feet and hands that still have not been able to function normally. Well, at the moment such as the need for rehabilitation and stroke recovery exercises by special teams of experts who had been in the hospital. But in addition to a team of rehabilitation in the hospital family support and a strong desire from oneself…

    • 300 Words
    • 2 Pages
    Decent Essays