Angiogenesis

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    Stroke Recovery

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    REVIEW Stroke is one of the major health problems worldwide and a leading cause of disability. But the treatment options for the management of stroke are limited. Thrombolytic reperfusion with recombinant tissue plasminogen activator (t-PA) is employed in acute phase in only less than 3% of all ischemic stroke patients while standard treatments involving rehabilitation provide some benefits for the recovery during chronic phase. However, many high-profile failures in a wide spectrum of pharmacologic neuroprotection trials have led to some pessimism in the field.[1] Recent findings suggest that enhancement of angiogenesis after focal cerebral ischemia may provide novel opportunities for better outcomes during stroke recovery.[2] Nowadays it is appreciated that new treatment strategies should target cerebral blood vessels and induction of angiogenesis will stimulate recovery processes including neurogenesis, synaptogenesis, and neuronal and synaptic…

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    Macrophages: A Case Study

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    The main role of PMN is phagocytosis of bacteria and tissue debri. PMNs are also a major source of cytokines, especially tumour necrosis factor-alpha (TNF-α), and second population that invades the wound consist of macrophages. The function of macrophages is phagocytosis , activation and recruitment of other cells by releasing various cytokines, growth factors such as Vascular endothelial growth Factor, Insulin like Growth Factor and Epidermal Growth Factor. Macrophages regulate matrix…

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    people and give them their life back. I want to use this knowledge that I will gain through this source collection and actually do something with it. I don’t just want to throw it away and never use it again. If can’t help other people maybe I can at least help myself. Throughout this project I intend to discover everything about stress the good and the bad. I intend to find out what goes on in the human body when the stress hormones are released. In some ways I intend to conquer stress and what…

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    Idiopathic pulmonary fibrosis (IPF) – the most common form of idiopathic interstitial pneumonia – is a chronic, progressive fibrotic lung disease that affects older adults. IPF is characterized by a continuing decline in lung function, poor survival, and limited therapeutic options. The invasive proliferation of fibrous tissue and scarring of the interstitium lead to a decline in forced vital capacity (FVC) (Richeldi et al. 2014). IPF has a poor prognosis; the median survival for the disease is…

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    Endothelial Cells

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    brought about by angiogenesis through the vascular network. It is therefore a physiologic process important to mechanisms like wound healing, menstruation, tissue growth and embryonic development (Griffioen & Molema, 2000). Endothelial cells which line the blood vessels are in direct contact with blood. Below the layer of endothelial cells, the pericytes (structural support cells) surround the blood vessels along with fibroblasts, smooth muscle cells, extracellular membrane and basement membrane…

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    There are 60,000 miles worth of blood vessels in a typical adult. End to end, that would form a line that would circle the earth twice (Li). Blood vessels can create life, but blood vessels can also cause death. The abnormal development of new blood vessels is called angiogenesis, which can cause the growth of cancer tumors and lead to many other diseases. William Li, the head of the Angiogenesis foundation, focuses on research dealing with extreme or deficient angiogenesis and nutrition’s…

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    The Causes Of Lung Cancer

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    In 2014, there was an estimated 1,665,540 new cancer cases diagnosed and 585,720 cancer deaths in the United States. Cancer remains the second most common cause of death in the United States, accounting for nearly 1 of every 4 deaths (American Cancer Society). Today, statistics show that 1 in every 3 Americans will be diagnosed with cancer sometime during their life (American Cancer Society). As cancer is becoming a more prevalent problem in society, there is an exceptional need for a solution.…

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    Zebra Fish Case Study

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    Cancer is a serious cause of death globally. Cancerous cells cannot be distinguished easily from the normal cells. Rapid development of cancerous cells depends on the process of Angiogenesis. Inhibition of the angiogenesis is a novel strategy in cancer treatment. Currently, herbal medicines are also being used, along with chemotherapy to reduce the side effects. For the present study, Neem was selected as it is a versatile tree in India. From the ancient times it has been considered as a mighty…

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    Borzomib Research Paper

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    Purpose:Bortezomib has been used in the treatment of relapsed/refractory multiple myeloma. This study is to examine whether sub-lethal doses of bortezomib (Borsub) attenuate angiogenesis in a choroidal neovascularization murine model. Methods:Laser photocoagulation was used to create choroidal neovascularization in mice. The volume of angiogenesis was assessed with isolectin GS-IB4 labeling in choroidal flat-mount. The content of vascular endothelial growth factor (VEGF) in the supernatants of…

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    Thalidomide

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    The drug slowed down brain activity which resulted in drowsiness and relaxation. This helped people fall asleep as well as relieve people of pain and nausea similar to those due to morning sickness. However, this sedative also caused severe birth defects to those who had taken the drug during their pregnancy. The drug was able to cross the placenta and interfere with the distribution and spread of nutrients to the baby. The drug proved itself to be a mutagen due to the fact that it commonly…

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