Hyperuricemia

Director Morgan Spurlock, in the documentary “Super Size Me” about fast foods, films to expose the negatives of fast foods to all of the U.S. to make people aware of the effects fast foods has in a candid tone. Morgan Spurlock supports his main objective successfully by giving straightforward facts. One example of how Mr. Spurlock supports his claim by stating “Nearly 100 million Americans today are either overweight or obese… Mcdonald's alone operates more than 30,000 joints in over 100…

and behavioral abnormalities. Overproduction of uric acid is another clinical feature associated with this disease. The disease is also known as Lesch-Nyhan Syndrome, HPRT Hypoxanthine Phosphoribosyl Transferase) deficiency syndrome and X-linked hyperuricemia. Michael Lesch and William Nyhan provided the first detailed clinical description of Lesch-Nyhan disease in 1964. Gene and Locus and Chromosome location The disease is associated with X-chromosome. It involves mutation of the HPRT gene…

uric acid such as Lesch - Nyhan Syndrome (LNS) and PRS superactivity. Lesch – Nyhan syndrome is an x-linked recessive disease and it is caused by a deficiency of the HPRT enzyme, causing a build- up of uric acid in all body fluids resulting in hyperuricemia (high level of uric acid in the blood) and hyperuricosuria (high level of uric acid in the urine) and potentially generating severe gout and kidney problems (Torres & Puig, 2007). The first symptom of this disease is the evidence of sand-like…

strange place, filled with many strange disorders and diseases, but the strangest of them all is Lesch-Nyhan Syndrome. This rare genetic disorder mostly affects males and is characterized by a variety of symptoms, which include “self-mutilation, hyperuricemia, choreoathetosis, and mental retardation.” (Wilson and Roy 1) The first documented case of Lesch-Nyhan Syndrome was in 1962, when a mother brought in her son (who was diagnosed with cerebral palsy), because he was experiencing painful…

70 to 79 years of age. The gout syndrome is “ caused by alteration in purine metabolism, the end product which is uric acid. This results in hyperurecemia and in the deposition of urate crystals in various tissues (Woo & Wynne, 2011, p. 869). Hyperuricemia can occur due three mechanisms: 1. Decreased excretion (underexcretors): Accounts for most cases and occurs when altered uric acid excretion results from decreased glomerular filtration (can contribute to the hyperurecemia of renal…

the prevention / management of gout Introduction: Gout is a type of inflammatory Arthritis and is the most common form. In most cases it is caused by an excess of uric acid in the blood. This surplus of uric acid is also known as hyperuricemia. Hyperuricemia can lead to a build up of fluid in the joints, which form small crystals both inside and around the joints (Schmerling, 2010). These crystals can cause intense pain, inflammation and swelling; which can be exceptionally…

beans, anchovies and dry beans. It is a special acid that travels through the kidneys in the blood and travels through kidneys and urine/urine and thus increases some conflicts. If a number of uric acid increases in the blood then the cause of hyperuricemia becomes. In one person, the quantity of uric acid should be between 2.4 to 6.0 milligrams, so that the body remains in balance, if the amount of uric acid in the individual is 3.4 to 7.0 milligrams, then it can be very dangerous for that…

Dietary assessment and food grouping Dietary intakes were assessed with a semi-quantitative food frequency questionnaire (FFQ) validated for use in those patients. This FFQ was designed by a panel of nutritionists and included culture-specific dishes and recipes. It was tested on a convenient sample to check for clarity and cultural sensitivity. Daily gram intakes of food items, energy, and macronutrients intake of participants were computed using the food composition data base of the…

symptoms and pathophysiology. I did not know much about this topic and very interested to know that gout is a form of arthritis caused by monosodium urate crystal deposition in and around a joints(Vannuchi 2012). Clinically significant hyperuricemia is serum urate level > 6.8 mg/dL (404 mcmol/L) due to likelihood of urate crystal deposition when urate concentrations > 6.8 mg/dL (404 mcmol/L) (Burbage 2014). Literature review shows that overall it is four times more common in…

OUTLINE INTRODUCTION ATTENTION GETTER: Have you ever felt intense pain at your joints like you are unable to move your joints because of the severe pain that you felt. That pain is extremely painful especially at the big toe followed by whether your knee, ankle, wrist, finger and elbow. The pain may subside in hours to days but you don’t even know what’s the problem. You might start to notice the warmth and swelling at your joint,…