Hemolytic anemia

Haemolytic anemia Features common to all haemolytic anemias: *A shortened red cell life span (normal = 120 days) or premature destruction of red cells. * Elevated erythropoietin levels and increased erythropoiesis in the marrow and other sites (extra medullary hematopoeisis), to compensate for the loss of red cells. *Accumulation of the products of hemoglobin catabolism from red cell destruction. Classification Of Hemolytic Anemias is based on: 1. The site / place of hemolysis i.e.wheteher it is intravascular or extravascular 2. Whether the underlying cause of red cell destruction is Extrinsic (Acquired) or Intrinsic (Hereditary). Intravascular Hemolysis: irrespective of the mechanism causing it, intravascular hemolysis is manifested…

CORRLEATION OF PERNICIOUS ANEMIA WITH HOMOCYSTEINEMIA AND HETEROZYGOUS MTHFR MUTATION HELPS DIFFERENTIATE FROM DIAGNOSIS OF THROMBOTIC THROMBOCYTOPENIC PURPURA Wu, Alex MD1, Chen, Kevin MD2, Sittambalam, Charmian MD1 1Department of Medicine, Franklin Square Medical Center, Baltimore, MD; 2Department of Hematology/Oncology, Franklin Square Medical Center, Baltimore, MD There are increasing number of recent publications that recognized the similarity between TTP and B12 deficiency, and that TTP…

where the fava bean cultivation and consumption is most common. People with favism significantly lack the enzyme glucose-6-phosphate dehydrogenase, or G6PD, which helps protect cellular integrity and clear out free radicals, which are molecules or atoms with unpaired electrons that disrupt cellular chemistry and cause a cell’s early death. Free radicals are especially dangerous in people with favism as there is not enough G6PD to clear them out, and more cells, most importantly red blood cells,…

Mildly affected infants can have little to no anemia and may show only hyperbilirubinemia because of the continuing hemolytic effect of the Rh antibodies that have crossed the placenta previously. Moderately affected infants can have a mixture of both anemia and hyperbilirubinemia/jaundice. In severe cases of fetal hyperbilirubinemia, kernicterus develops. Kernicterus is a neurological condition caused by the deposition of bilirubin into central nervous system tissues. Kernicterus typically only…

Hereditary Spherocytosis and Autoimmune Hemolytic Anemia Introduction Scientifically, hereditary spherocytosis has been known to be a form of an unusual disorder that generically affects a considerable populace around the globe. By definition, hereditary spherocytosis is a term that is accorded to an inherited blood condition that contains abnormally shaped red blood cells (RBCs) (Hsiao et al, 2013). This abnormality has been associated with the reduction of RBCs supply and results into an…

most important in red blood cells since it helps to get rid of chemical elements that would otherwise destroy the cell. These destructive chemical elements are called free radicals, molecules or atoms with unpaired electrons looking for a pair in already complete molecules. As free radicals search for their pair, they cause chemical reactions which can disrupt cellular chemistry and lead to the cell 's early death. The cell membranes burst and are destroyed, causing hemolytic anemia Its…

For doctors, the hardest part is sometimes not the years of medical school, or the vast amounts of debt, it 's taking these years of education, and explaining it simply to someone else. I could tell a woman that her next child may suffer from hemolytic anemia and she must have RhoGAM injection. However, it is highly unlikely that she would understand what I’m trying to convey by hemolytic let alone what a RhoGAM entails. Simply explaining to a ninety-year-old how to use the bed controls teaches…

called the autoimmune hemolytic anemia. This disorder occurs when the body immune system malfunctions and makes antibodies that act against the cells. What could cause the body’s immune system to turn against its own red blood cells? Sometimes the cause is unknown, but at times the destruction occurs for no known reason within the autoimmune hemolytic anemia disorder. The disorder is also called idiopathic autoimmune hemolytic anemia since the exact cause of this disease cannot be determined and…

What is Hemolytic Anemia? Hemolytic anemia is a condition in which an individual does not have enough healthy red blood cells in the body. Red blood cells usually last approximately 120 days in the body. In hemolytic anemia, red blood cells in the blood are destroyed earlier than expected. The spleen traps and destroys healthy red blood cells. Hemolytic anemia occurs when the bone marrow is unable to replace the red blood cells that are destroyed. It can also come from red…

At this moment, this young boy fits the diagnosis of Normocytic anemia with increased red cell production along with leukopenia. The patient presents with symptoms consistent with severe anemia including of pallor, fatigue, tachycardia, tachypnea, and hypotension. The patient’s new systolic ejection murmur is most likely related to increased semilunar flow due to the anemia. The recent throat infection and subsequent antibiotic treatment are the most probable cause of these symptoms. The…