Glucose-6-phosphate dehydrogenase deficiency

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  • Survival Of The Sickest Analysis

    to the lymphatic system, are deficient in iron. It is also known that infectious agents thrive on iron, and macrophages with normal levels of iron are exploited by the infectious agents. However the iron-deficient macrophages cannot be exploited, and are significantly better at combating bacteria because they limit the availability of iron. Thus, during the bubonic plague pandemic of 1347-1350 in Europe, people with hemochromatosis were resistant to the disease due to their iron-deficient macrophages, and they survived the plague to reproduce and pass on the gene for hemochromatosis. In an individual with diabetes, blood sugar can rise to dangerously high levels as the pancreas is unable to produce enough insulin to help the body use glucose (Type 1 diabetes), or their cells are insulin resistant (Type 2). Diabetes can be diagnosed by urine tests, as one of the symptoms of diabetes is the frequent urge to pass urine, which contains large amounts of sugar in a diabetic, in addition to blood tests that examine the amount of sugar in the blood. Type 1 diabetes can be managed by daily insulin injections, while Type 2 can be managed by blood sugar monitoring, exercise, weight loss, medication, and a careful diet. Left unmanaged, high blood sugar levels can cause rapid dehydration, coma, and death. Dr. Moalem states that diabetes can cause severe health complications even when tightly managed, such as, “blindness, heart disease, stroke, and vascular disease that often leads to…

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  • Survival Of The Sickest By Moalem

    the circulatory system. It is an inherited enzyme deficiency carried by 400 million people, the most common enzyme deficiency in the world. It is also called the glucose-6-phosphate dehydrogenase (G6PD) deficiency because of the body 's lack of this enzyme. This enzyme is typically found in all of the body 's cells, but is most important in red blood cells since it helps to get rid of chemical elements that would otherwise destroy the cell. These destructive chemical elements are called free…

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  • Analysis Of Survival Of The Sickest

    Jonathan Prince, it discusses diseases such as hemochromatosis, diabetes, and favism or glucose 6 phosphate dehydrogenase (G6PD) deficiency which all are deadly but helped humans survive in the past. Hemochromatosis is an inherent disease that disrupts the metabolism of iron in the body. Instead of letting excess iron pass through your body, the disease makes the body think that it never has enough iron and the body will keep absorbing iron for indefinite amounts causing high…

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  • Aniline Case Studies

    Irregular heart rhythm, acute congestive heart failure and heart block this may be due to delivery of the oxygen to tissues is decreased . • CNS(central nervous system): Confusion, weakness, dizziness, loss of consciousness, and disorientation • Renal: urination is painful; appearance of blood or methemoglobin in urine, and decrease in the urinary output. • Dermal: Mild irritation of skin. • Ocular: Moderate to the severe irritation of eye, discoloration , and damage of cornea. • Respiratory…

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  • Human Genome Essay

    Pharmacogenetics and Pharmacogenomics an article written by Munir Pirmohamed the NHS Chair of Pharmacogenetics at Liverpool University; “The history of pharmacogenetics stretches as far back as 510 b.c. when Pythagoras noted that ingestion of fava beans resulted in a potentially fatal reaction in some, but not all, individuals.” Interest in the topic began to grow in the 1950’s with the discovery of “abnormal butyrylcholinesterase enzyme in psychiatric patients who exhibited prolonged muscular…

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  • Single Genetic Disease In Nigeria Case Study

    the agonies that couples go through, when this incompatibility is detected after marriage and the biblical injunction of ‘for better for worse’ still has to be enforced. The factors that contribute to the prevalence of congenital disorders and the current impediments that are limiting community genetic services in Nigeria Some factors have been identified to be contributory to the high rate of congenital disorders and limiting community genetic services in LMIC and some of these are: general low…

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