Hemostasis

smoothness and the finely tuned balance of clotting factors (WebMD, 2014). Hemostasis is concerned with the clotting, or stopping, of blood. The medical term used to describe a blood clot is thrombus. In the blood, there is a liquid called plasma that makes up about half of the blood. Plasma contains proteins that help blood to clot, transport substances through the blood, and perform other functions. Blood plasma also contains glucose and other dissolved nutrients (WebMD, 2014). A blood clot can be beneficial or of great consequence to the body. A thrombus can form as a part of the normal repair process of the body. For example, a thrombus can form when there is damage…

post-tonsillectomy bleeding cases.4 Such bleeding can be classified as primary or secondary hemorrhage. Primary hemorrhage occurs within the first 24 hours of surgery as a result of inadequate hemostasis. Nearly 75% of post-tonsillectomy bleeding results from primary hemorrhage occurring within 6 hours of surgery.4 Secondary hemorrhage occurs more than 24 hours following surgery; it commonly occurs on the sixth day after the operation and is associated with either premature sloughing of the…

“A Novel Application of Microfluidic Assay to Evaluate the Role of Calponin in Platelet Function and Clot Formation” Introduction: Platelets are a very important aspect of blood clotting. They are also essential in the evolution of clots in Coronary and Cerebral arteries, which cause heart attacks and strokes, respectively. Every year, 610,000 people die of heart disease in the United States; this is 1 in every 4 deaths. Cardiovascular disease is the number one cause of death in the United…

Hemophilia Research Paper If you get a small papercut, it’s no big deal. Yes, it will hurt for a few minutes, but in a few days it’ll scab over, and be just fine. Unfortunately, it’s not the same case for everyone. There are many blood disorders, but one of the most common is hemophilia. Hemophilia affects over 200,000 people in the US each year. It causes the subject’s blood to not be able to clot properly, and leads to excessive bleeding (external and internal). The excessive…

a. Explain why the PTT is abnormal and the PT is normal? • Hemophilia is a disorder that results in prolonged PTT. Partial thromboplastin time (PTT) is a measure of a time that is required by plasma to form a clot when it comes in contact with agents which activates the contact factors. PTT assesses intrinsic and common pathway of coagulation. Prothrombin time ( PT) measures the time needed for plasma to form a clot in the presence of tissue factor. PT evaluates extrinsic and common pathway of…

According to the Center for Disease Control and Prevention, Hemophilia affects 1 in 5,000 male births which factor out to be about 400 babies born with hemophilia each year [3]. Hemophilia is classified as one of the oldest and longest lifelong bleeding disorders that are inherited, meaning passed down from parents to their children. This disorder occurs when the protein in the blood or platelets that assists the blood to clot is absent or not functioning properly, resulting in extended…

Von Willebrand Disease Von Willebrand disease is the most common bleeding disorder. It occurs when the body makes too little of the von Willebrand factor (VWF), a protein that helps blood clot, or when the VWF is misshapen and does not work the way it should. VWF is a carrier for another protein, called factor 8, that helps blood clot. When VWF levels are low or when VWF is not working properly, factor 8 levels are low as well and the body is less able to form stable blood clots. There are…

Hematology is the study of blood and how it relates to health and disease (“Blood Disorders”). Hematologists study blood disorders, what causes them, and how to prevent, treat, and cure them (“Blood Basics”). Advances in this field have helped increase the quality of life in people who suffer from blood disorders. For example, CML (Chronic Myelogenous Leukemia) used to be treated with chemotherapy, which kills rapidly dividing cells, both healthy and diseased. Because of studies in hematology,…

The human body has approximately 5 liters of blood in circulation at any given time. Therefore, when a blood vessel is ruptured or damaged, as a result of an injury, it is vital that the loss of blood is minimalized. The process that enables this is called haemostasis. In terms of Rosemary’s ‘quite bad’ cut on her finger, as a result of slicing it with a kitchen knife, her body will react quickly by following all three stages of haemostasis. We can assume this as a result of the bleeding taking…

Genetic Disease Summary: Hemophilia A Hemophilia is an inherited bleeding disorder that slows down or prevents the blood clotting process. There are two main types of hemophilia: hemophilia A and hemophilia B. Hemophilia A, which is known as classic hemophilia, is caused by a mutation in the F8 gene. People with hemophilia often display excessive bleeding, including bleeding in the stool and urine, though it is usually painless. Joints are also heavily affected, causing swelling and decreased…