Genomics

The prospect of continuing research and broadening my knowledge of biomedical sciences excites me. The mammalian genetics Ph.D. program at the Sackler School in collaboration with The Jackson laboratory would best help me achieve my goals. While completing an undergraduate degree in cellular and molecular biology at the University of Rhode Island, I have worked in the laboratory of Dr. Niall Howlett investigating the biochemical properties of Fanconi anemia, an inherited bone marrow failure…

Ever since scientists uncovered more information about genes, DNA, etc., a lot of scientific advancements linking to the topic have risen like, DNA fingerprinting, gene therapy, and manipulating genes. Lily E. Kay’s Who Wrote the Book of Life: A History of the Genetic Code published in the year 2000, talked about the detailed history of one of the most important events in modern science, the genetic code. Genetic code is the sequence of organic bases on the double strands of DNA. The bases are…

We are now beginning to understand the negative effects of chronic sleep deprivation, and how it impacts our ability to function as well as our physical and mental health. However, we still need to better understand the functions of sleep to develop new treatments for the countless disorders that affect one’s ability to maintain sleep homeostasis. The answer to this is to conduct further scientific research. Millions of people go through life with undiagnosed chronic sleep disorders. The word…

decided to explore the consequences of genomic research through its Ethical, Legal, and Social Implications (ELSI) program. The HGP began in 1987 with the motive of needing to know what drives all basic science. There was much competition between the private sector and the public sector, with J. Craig Venter leading the private sector effort. By 1998 Venter had established Celera Genomics, with sequencing capacity fifty times greater than The Institute for Genomic Research. By June 17, 2000, he…

have an influence on chromatin features. These features include things such as nucleosome position, binding factors, and histone modifications. Active chromatin are more accessible compared to other chromatin and show more decay as a function of genomic distance. They are also organized into linear domains and are shorter than other chromatin types. They can be organized into TADs which suggests that they are spatially independent. Internal interaction is different between cells of a different…

brain tissue. The cancer is highly malignant and is proto-oncogene. It’s characterized by uncontrolled cellular proliferation, diffuse infiltration, tendency for necrosis, significant angiogenesis, intense resistance to apoptosis, and widespread genomic aberrations. The tumor arises from the astrocytes which are star shaped cells that make up the brains supportive tissue. As a result of the cancer spreading through the brain tissue so quickly, most people who get this disease will not survive.…

genes, which are molecules that are passed from parents to offspring. They are responsible for making the proteins in our bodies, and determining how similar or different we are from one another. “The topic of nutrigenomics is a branch of nutritional genomics, and is the study of the effects of foods and food constituents on gene expression”(Wikipedia). It studies specifically on the functional interactions of food, and its components with the genome at the molecular and cellular level, with the…

Diagnostic Tests: Susan will go through many tests to determine the stage of her cancer. Some of the tests she will undergo include axillary lymph node status, tumor size, estrogen and progesterone receptor status, cell-proliferative indices, and genomic assays. Lymph node status determines if the cancer has spread, if it has spread the risk of recurrence is greater. Tumor size tests the size of the tumor. The larger the tumor is the harder it will be to treat and the risk of recurrence…

Decision curves showed that the genomic classifier net benefit exceeded that of clinical-only models, being the predominant predictor of metastasis on multivariable analysis 19. A 2013 study by Schubert et al 20 has taken into consideration the role of distinct micro-RNA expression profiles…

us from a traditional “one-size-fits-all” approach, based on broad population averages, to a more precise health care that is customized for each individual patient. The sequencing of the human genome has initiated a genomic era of personalized medicine. Knowledge of patients genomic, gained through high through-put next generation sequencing (NGS) is offering opportunities for biological insights and clinical diagnostics. Advances in this field have led to powerful new discoveries and…