Genomics

The prospect of continuing research and broadening my knowledge of biomedical sciences excites me. The mammalian genetics Ph.D. program at the Sackler School in collaboration with The Jackson laboratory would best help me achieve my goals. While completing an undergraduate degree in cellular and molecular biology at the University of Rhode Island, I have worked in the laboratory of Dr. Niall Howlett investigating the biochemical properties of Fanconi anemia, an inherited bone marrow failure…

genes, which are molecules that are passed from parents to offspring. They are responsible for making the proteins in our bodies, and determining how similar or different we are from one another. “The topic of nutrigenomics is a branch of nutritional genomics, and is the study of the effects of foods and food constituents on gene expression”(Wikipedia). It studies specifically on the functional interactions of food, and its components with the genome at the molecular and cellular level, with the…

brain tissue. The cancer is highly malignant and is proto-oncogene. It’s characterized by uncontrolled cellular proliferation, diffuse infiltration, tendency for necrosis, significant angiogenesis, intense resistance to apoptosis, and widespread genomic aberrations. The tumor arises from the astrocytes which are star shaped cells that make up the brains supportive tissue. As a result of the cancer spreading through the brain tissue so quickly, most people who get this disease will not survive.…

While Eric Lefkofsky graduated from the University of Michigan with a law degree, his real talent is being an entrepreneur who thrives on risk. In fact, Lefkofsky's latest venture is a genomics company, even though he has no medical background. As the co-founder and CEO at Tempus, Lefkofsky oversees a the compilation of a massive database that physicians can use to personalize cancer therapies. Actually, Tempus is based on utilizing big data, as were Lefkofsky's previous ventures, therefore it…

Diagnostic Tests: Susan will go through many tests to determine the stage of her cancer. Some of the tests she will undergo include axillary lymph node status, tumor size, estrogen and progesterone receptor status, cell-proliferative indices, and genomic assays. Lymph node status determines if the cancer has spread, if it has spread the risk of recurrence is greater. Tumor size tests the size of the tumor. The larger the tumor is the harder it will be to treat and the risk of recurrence…

Decision curves showed that the genomic classifier net benefit exceeded that of clinical-only models, being the predominant predictor of metastasis on multivariable analysis 19. A 2013 study by Schubert et al 20 has taken into consideration the role of distinct micro-RNA expression profiles…

us from a traditional “one-size-fits-all” approach, based on broad population averages, to a more precise health care that is customized for each individual patient. The sequencing of the human genome has initiated a genomic era of personalized medicine. Knowledge of patients genomic, gained through high through-put next generation sequencing (NGS) is offering opportunities for biological insights and clinical diagnostics. Advances in this field have led to powerful new discoveries and…

described in the preliminary data, all of the behavioral, genomics, bioinformatics, gene manipulation and biochemical studies are feasible between the Puthanveettil and Stackman laboratories. Additionally, we have obtained support letters from the leading experts in the field of lncRNA biology and regulation, such as John Rinn from Harvard University and the Broad Institute and our colleague at Scripps, Kevin Morris. Letters for genomics, bioinformatics, mouse behavior and imaging analysis are…

Mathew Issac Issac 1 Professor Batorsky WRT 101 11/30/2016 Brain Development Does the question " Why is he/she smarter than me? " brush through your mind whenever you see that someone always gets better grades than you do? Brain development is affected…

Genetic and genome field development has been vastly expanded over the past decade and with its positive impact on areas of science, medicine, society there is also negative impact such as the ethical issues that can follow. The developments of new genetic technologies will raise some of these ethical issues that will affect the person as well as the society as the whole. In 2010 ethical issues was emerge as big controversial problem within the scientific community by Rebecca Skloot, the…