Agonist

C2A. Preliminary Results: C2A1. Establishment of fear conditioning protocols to study consolidation and extinction of fear memories: Presented below is published and preliminary data to establish feasibility for the proposed studies; the conditioning and extinction protocols are sensitive to manipulations that enhance or impair fear memory storage and the acquisition and consolidation of extinction. We reported (Zhang et al. 2013) that mice given post-training serotonin 2A receptor agonist TCB-2 (1mg/kg, open bar) exhibited significantly greater freezing than vehicle-treated mice (black bar) during a context test 24h after fear conditioning (A). These data indicate that activation of 5HT2A receptors enhances storage of fear memory. In a second…

Buprenorphine 4.2.1 Physical Chemistry Buprenorphine (BUP) a semisynthetic alkaloid is a derivative of oripavine, and thebaine the parent compound for opioids. BUP is partially soluble in water, soluble in methanol and freely soluble in acetone with a Pkb (dissociation constant) of 8.5 rendering it a weak base. It is also soluble in acidic pH and poorly soluble in basic medium. It has a molecular weight of 467.7 in its base form and 504.1 in its salt form [HCL; NIH, 2014]. 4.2.2.…

What is meant by “agonist and antagonist muscle pairs”? Give an example What is meant by agonist in muscle pairs is that it does the majority of the workload in an exercise and is considered the prime mover (primarily responsible for movement). The antagonist in respect to the agonist counteracts. The antagonist helps allow the agonist to perform a task. An example could be the biceps brachii contracts when doing elbow flexion. While the antagonist would be the triceps brachii relaxing during…

Factors Predicting Adverse Outcomes in Patients With Uterine Myomas Undergoing GnRH Agonist Therapy: A Meta-Analysis Rahma Novita Asdary Dharma Husada Midwifery Academy Email: novita_asdary@hotmail.com ABSTRACT Context : GnRH Agonist (GnRHa) maybe the most effective drugs in the management of myomas. However, there remains some uncertainty regarding the efficacy of the therapy because of conflicting reports in the literature. Objective : This research objective is to identify potential…

RT AND TLR AGONISTS TLR agonists can be used in combination with RT to enhance the antitumor immune response. This combination therapy was more efficient than either treatment alone and provided protection against subsequent tumor rechallenges. Brody et al treated 15 patients with metastatic low-grade B cell lymphomas with low doses of radiation (2 x 2 Gy in 2 consecutive days). They combined the RT with intratumoral injections of CpG, into the same irradiated site, before the first dose of…

The agonist of "The Tell-Tale Heart" is an exemplary case of Poe's problematic narrator, a man who can't be trusted to tell the target truth of what is happening. His shakiness turns out to be promptly apparent in the first passage of the story, when he demands his lucidity of psyche and the qualities any indications of frenzy to his apprehension and over-sensitivity, especially in the territory of hearing. Nonetheless, when he completes his announcement of rational soundness, he offers a record…

Dopamine D2 receptor agonists Bromocriptine quick release (QR) is a dopamine D2 receptor agonist licensed in some countries outside Europe for treatment of T2DM as an adjunct to lifestyle changes . The effect of bromocriptine on glycaemic parameters has been noted since 1980. The drug provides a morning boost to hypo¬thalamic dopamine levels, consistent with normal diur¬nal glucoregulation, and contributing to a reduction of sympathetic tone, neural suppression of hepatic glucose production and…

Triptorelin: Product Description Triptorelin is a synthetic decapeptide hormone which falls under the gonadotropin-releasing hormone agonist (GnRH agonist) utilized as the pamoates or acetate salts. GnRH is Triptorelin (GnRH) initiates persistent stimulation of the pituitary glands and therefore leads to a decline in the levels of follicle stimulating hormone (FSH) and gonatropins luteinizing hormone (LH) secreted by the pituitary gland. It achieves this function by over stimulating the body’s…

Inverse agonism is phenomenon associated with G-protein coupled receptor (GPCR), in which inverse agonist binds to the same receptor as an agonist but induces an opposite pharmacological response to the agonist. For inverse agonist response the receptor must have an intrinsic activity in the absence of any ligand1,2. How inverse agonist act? According to the two state receptor theory, receptors are quiescent at rest (Ri) and are stimulated by drugs (R*, receptors are switched on) known as…

In the treatment of asthma, two drug groups are at the forefront, β2-agonists (like salbutamol) and corticosteroids. Salbutamol is a β2-agonist and a physiological antagonist of bronchoconstriction and is often prescribed in an “as required” manner in the relief of symptoms (Taylor and Hancox, 2000). Salbutamol acts on a g-protein coupled receptor (GPCR) which, through a biochemical intracellular cascade ends with activation of protein kinase A, which then phosphorylates many regulatory proteins…