Caenorhabditis elegans

The effects of gene mutation on Olfactory Sensory Neurons in Caenorhabditis Elegans Amira Brown University of California, Santa Barbara Abstract This experiment examines the effects of distinct odorants on chemotaxis behavior of the nematode worm, Caenorhabditis elegans (C. Elegans). Nematode worms are appropriate for sensory physiology studies because its neuronal wiring is similar to that of humans. We focused on the role of three sensory neurons in the nose of the nematode—the 1) AWA and 2) AWC neurons are involved in chemo-attraction and the 3) AWB neurons are involved in repulsion. With the use of RNA interference (RNAi), we diminished or eliminateed specialized proteins within the worms to test if their olfactory…

Introduction Caenorhabditis elegans is a common organism that is used in many experiments due to its easy upkeep, low cost, short life cycle, fast reproduction, large reproduction size, and genetic manipulability with transparent body structure (Maxwell C. K. Leung, Phillip L. Williams, et al.). The use of C. elegans has allowed many discoveries to be made throughout history. One experimental technique that enhances their use is a green fluorescence protein (GFP), this allows different regions…

1.1 Caenorhabditis elegans (C. elegans) Caenorhabditis elegans is a free-living non-parasitic, non-infectious, non-pathogenic, transparent Nematode (roundworm). It has a full grown length of about 1mm, a life span of around 3 weeks and is found in temperate soil environments where it survives by feeding on microbes such as bacteria. [1] Consisting of about 1000 somatic cells as an adult, C. elegans is amenable to genetic crosses and produces a large number of progeny, at times even…

1. What is the species name of the model/study organism? If the study is looking at human disease choose the disease causing organism. If the study is on some aspect of human physiology or anatomy, the model organism is a human. The study followed one White family and one Italian family to see how the mutation of a Manganese Transporter, SLC30A10, causes a variety of diseases such as Parkinson’s and Chronic Liver Disease. The model organism of the study is the Homo sapien. 2. Intellectual merit…

One great organism to study is Caenorhabditis elegans (C.elegans ) because it is hermaphrodites, transparents and small enough to observe under the microscope. After adding mutagens to them, scientists can get all kinds of freak worms after few days. “Bag of worms” are one of them. It can not lay eggs so its body occupied with dozens of eggs. When eggs hatched inside the worm, larvae eat the mother worm and them come out. Ambros, a scientists who just finished doctor degree at MIT, first…

Beatrice Torres June 23, 2016 Breakthroughs: Biomedical Research Yishi Jin, a renowned researcher, developed a study called "Neural Development and Axon Regeneration in C. elegans". Her research revolved around axon regrowth and the restoration of mature neurons, problems that arise quite frequently as we, both, age and face unfathomable and unexpected accidents. She…

Sensitivity of Cancerous C.elegans with Mitochondria Dysfunction Mitophagy is a selective autophagic elimination of damaged or excessive mitochondria, especially when cells are under adverse stress. Mitophagy has been identified as the cause of various human diseases and even cancer. In recent years, researchers gradually regard mitophagy as the target for cancer treatment, although the role of mitophagy in the developmental and metabolic process of cancer is still not clear. In this…

other model systems. Hobert (2000) believes, that the patterns of these LIM-homeodomain proteins is evident from studies about Drosophila to C. elegans. LIM proteins have their own transcription factors and cytoskeletal elements. Structurally, a LIM domain has cysteines with 2 zinc fingers. These LIM homeodomain (LIM-HD) proteins regulate the formation of cell line cells and influence differentiation. (Dawid et al., 1995) To control these proteins, it is suspected that they all have a…

Caenorhabditis elegans C. elegans is a nematode worm that considers as one of the simplest multicellular model organism. It is a free-living soil animal that feeds on microbes in decaying plant environments while in vitro, it mainly feeds on bacterial lawn (40). Sydney Brenner has proposed C. elegans as an experimental model organism and it has been used in biological fields, it played a huge role in the understanding and development in the knowledge about multicellular organisms since 1960s…

In 1963, the South African biologist Sydney Brenner proposed C. elegans as a model system for studies of development and neurobiology. Researchers share their findings in C. elegans genome via the internet with other researchers from around the world. The process of sharing the genome database on the world wide web provides a working framework for researchers who are working on the human genome project In 1969, John Sulston developed a technique to freeze and thaw the worm. As a result, the…