Synthesis Essay

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  • Solid Phase Synthesis Essay

    A novel solid-phase synthesis methodology of N-substituted-2-aminothiazolo[4,5-b]pyrazine derivatives was developed. The key step in this synthesis strategy is tandem reaction of isothiocyanate terminated resin 2 with o-halo-2-aminopyrazine, affording cyclized 2-aminothiazolo[4,5-b]pyrazine resin 4. To increase the diversity of our library, Suzuki coupling reaction was performed at the position C6. Further functionalization of 2-aminothiazolo[4,5-b]pyrazine core skeleton with various electrophiles such as alkyl halides, acyl chlorides, and sulfonyl chlorides and cleavage from the resin with TFA in DCM generated N-alkyl-, N-acyl-, and N-sulfonyl-2-aminothiazolo[4,5-b]pyrazine derivatives. This synthetic strategy can efficiently provide a library…

    Words: 877 - Pages: 4
  • Nucleoside's Susceptibility To Depurination

    α-phenylcinnamoyl, naphthaloyl, 3-methoxy-4-phenoxybenzoyl, 9-fluorenylmethoxycarbonyl (FMOC), and tert-butylphenoxyacetyl (t-PAC) groups (Figure 2.1.7) provides greater resistance to depurination than with N6-benzoyl (reviewed in Beaucage and Iyer, 1992). It is believed that in the case of acyl-protected purine nucleosides under acidic conditions, the initial site of protonation is N7, rendering the protonated species more prone to glycosidic cleavage. Naturally, caution should be exercised in…

    Words: 1764 - Pages: 8
  • 12 Principles Of Ibuprofen

    Green Synthesis of Ibuprofen Green Chemistry is a new approach and perspective of chemistry that can improve human lives and maximize efficiency. It is a branch in chemistry that explores and examines techniques to reduce and eliminate hazardous and harmful substances. These harmful substances effect humans and the environment in multiple ways, the twelve principles of Green Chemistry can help minimize them. The twelve principles include prevention of waste, the design of less hazardous…

    Words: 820 - Pages: 4
  • Synthesis

    Synthesis paper In my paper I wish to synthesize the works that we have covered in class by showing how they work together to show us the special elements found in every good story. All of the works that we have covered this year work together in many different ways. They also all share many elements of story such as conflict, themes, characters and development, setting, and plot. These elements differ in many ways such as themes being a very broad part of story and plot is a vast element. For…

    Words: 1365 - Pages: 6
  • Synthesis Of Trans-Cinnomine Synthesis

    Bromination of trans-cinnamic acid Purpose and Introduction The halogenation of of trans-cinnamic acid using pyridinium tribromide was connected in the organic solvent glacial acetic acid in order to verify and test which addition mechanism the reaction would follow. In the anti-addition mechanism, bromines attach themselves on opposite sides of the alkene functional group in a compound. In a syn-addition, the attach to the same side of the alkene. The reaction synthesis was completed by using a…

    Words: 976 - Pages: 4
  • Ballad Of The Sad Cafe And Anthony

    The trope of nostalgic and wistful people looking back on their teen years, the good years, approaches stereotype. Julian Barnes’s The Sense of an Ending, on the surface, appears to employ the same stereotype of a wistful old man experiencing a bout of retrospection for his lost friend and the times he once had. The narrator of Carson McCullers’s “Ballad of the Sad Café” in The Ballad of the Sad Café works with the same forlorn recollection of when the town was more alive. Both narrators use two…

    Words: 1401 - Pages: 6
  • Dna Synthesis

    strands of DNA (Campbell et al., 2015). After the two daughter strands of DNA have been produced, it is time to proofread and repair the DNA sequence. This process is so important because any mistake in DNA replication can result to DNA mutation and will lead to various genetic diseases such as sickle cell anaemia, Huntington’s disease and many more (Cooper, 2000). Thus, the accuracy of DNA replication cannot be attributed solely to the specificity of the base pairing. According to Khan Academy…

    Words: 1283 - Pages: 6
  • Synthesis Of Phthalocyanines

    devices. In addition, their novelty is rapidly growing in other fields where they are used as sensing elements in chemical sensors, electrocatalysts, liquid crystals, electrochromic display devices, information storage systems, semiconductors, functional polymers and molecular metals, among others. They have also found use in photodynamic therapy (PDT). [15-17] Synthesis of Phthalocyanines A number of different methods are available for the synthesis of phthalocyanines. Phthalonitriles are…

    Words: 1318 - Pages: 6
  • Phenacetin Synthesis

    Phenacetin (C10H13NO2) can be synthesized from various organic compounds. The two primary compounds used for synthesis in this lab were Acetaminophen (C8H9NO2) and p-Phenetidine (C8H11NO). Both of these compounds have similar organic structures, however, Acetaminophen resulted in a more pure form of Phenacetin. Additionally, both of these compounds had to undergo specific chemical reactions, in order to form the same molecular structure as Phenacetin. Finally, these compounds had to be…

    Words: 733 - Pages: 3
  • Chemical Synthesis

    The goal of this experiment was to perform a synthesis of aspirin/ acetylsalicylic acid from salicylic acid, using a chemical synthesis procedure. The synthesis involved breaking the bond with acetic anhydride, also required heat and a catalyst, phosphoric acid, in order to beak and extract the bond. The solution used water in order to purify the solution in the way of recrystallization. The product was characterized using IR spectroscopy and melting point. The pure aspirin product that was…

    Words: 805 - Pages: 4
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