12 Principles Of Ibuprofen

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Green Synthesis of Ibuprofen
Green Chemistry is a new approach and perspective of chemistry that can improve human lives and maximize efficiency. It is a branch in chemistry that explores and examines techniques to reduce and eliminate hazardous and harmful substances. These harmful substances effect humans and the environment in multiple ways, the twelve principles of Green Chemistry can help minimize them. The twelve principles include prevention of waste, the design of less hazardous chemical syntheses, use of less toxic solvents and renewable feedstock, and design chemicals and products to degrade after use. These principles are seen in the making of synthetic organic chemical substances. 1 By changing techniques and applications of organic
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It is also used for treating pains such as arthritis, menstrual cramps, and headaches. 3 Ibuprofen is used among people of all ages ranging from children who are six months old to elderly people. If the wrong dosage is taken it can cause serious risks such as damage to the intestine and stomach. The medication can cause heart attacks and strokes to people without a heart disease. Ibuprofen is sold in large volumes therefore many chemical industries are interested in composing a greener alternative that will lower the energy use, cost, minimize waste, and lower the synthetic stages.
The English company, Boots Pure Drug Company, was the first to discover ibuprofen in 1960. Ibuprofen was then known as Aspro, Panadol, and Nurofen and was available with out a prescription. The synthesis consisted of six steps, which obtained waste and secondary by products and a very poor atom economy. Boot had a patent, which is a license given by the government granting rights and a title for a certain period of time, when the patent ran out in the 1980’s any company could make the drug. Thus the company called BHC came up with a new green synthesis in 1992.
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As shown the method BHC derived is an excellent example of how green chemistry has changed the pharmaceutical industry. Large quantities of Ibuprofen are manufactured and consumed daily, by using a greener method the amount of cost and energy has decreased significantly. 7 The new green method has spread extensively; a partner company called BASF Corporation, the largest production plant in the world, uses the process to manufacture massive amounts of ibuprofen. Since it is made in large bulks, the green route supply’s more ibuprofen at a cheaper cost and in less time, this means manufacturers make a greater

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