Tumor necrosis factor-alpha

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    A deficiency in the female hormone, estrogen, will decrease bone restoration which could eventually lead to greater possibility of osteoporosis. This female hormone has an effect on bone cells and can impact the body through the endocrine system. It has been known that in order to develop rheumatoid arthritis it was most likely obtained through genetic factors rather than the environment or lifestyle. Each individual gene can contribute to the overall development of this disease. One gene that is a factor for rheumatoid arthritis development is the HLA-DRB1 gene. When this gene is paired with other variations of the gene then the likelihood of developing RA are…

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    Necrosis Research Paper

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    Necrosis occurs as a result of external injury due to cellular injury, bacterial toxin or trauma to a particular area of the body. Necrosis differs from apoptosis in a couple of ways. First, the morphological changes that a cell undergoes are different in necrosis compared to apoptosis. Secondly, apoptosis is highly regulated, however, necrosis is unregulated. The morphological changes that a cell undergoes during necrosis are the swelling of the cytoplasm, irreversible damage to the plasma…

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    Recombinant Hepatitis B

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    In a 1997 study published in the New England Journal of Medicine, a randomized double-blind trial with 180 participants suffering from rheumatoid arthritis did not reveal anything unsafe about recombinant TNF (Moreland, 1997). Three studies conducted in 2001 showed a remarkable safety profile for a different variation of recombinant human necrosis factor (binding protein-1). Intravenous, intramuscular, or subcutaneous injections were given to healthy volunteers. The safety profile was based on…

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    Tumor Necrosis Factor-A

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    Discussion Question #6 Article Summary My research paper is about a cytokine --- Tumor necrosis factor alpha, which is involved in systemic inflammation and is found in high concentration in patients diagnosed with autoimmune disorders. The article chosen describes the effects caused by a change in the level of cytokine Tumor necrosis factor-a (TNF-a). The cytokine TNF-a is a proinflammatory, recognized to encourage HIV-1 reproduction and is involved in the development of HIV-1 related…

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    Borzomib Research Paper

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    Purpose:Bortezomib has been used in the treatment of relapsed/refractory multiple myeloma. This study is to examine whether sub-lethal doses of bortezomib (Borsub) attenuate angiogenesis in a choroidal neovascularization murine model. Methods:Laser photocoagulation was used to create choroidal neovascularization in mice. The volume of angiogenesis was assessed with isolectin GS-IB4 labeling in choroidal flat-mount. The content of vascular endothelial growth factor (VEGF) in the supernatants of…

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    vascular inflammation may also contribute to increased peripheral resistance and vascular damage in hypertension. Interleukin 17 has garnered interest for its role in increasing the production of several other immune system chemical signals thought to be involved in hypertension such as tumor necrosis factor alpha, interleukin 1, interleukin 6, and interleukin 8.  At very high blood pressures (systolic 210 and/or diastolic 120 mm Hg), a subset of patients develops fulminant arteriopathy…

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    The primary inflammatory cytokines: Tumor necrosis factor (TNF) is a proinflammatory cytokine which is produced by macrophages, T cells, B cells, natural killer cells, fibroblasts, neutrophils, keratinocytes and tumor cells [13]. It is produced during early inflammatory response. It mediates the production of other cytokines, chemokines and adhesion molecules [14]. It also increases vascular permeability, which leads to migration of activated immune cells to the site of infection [15,16]. TNF…

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    Benznidazole Essay

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    CD is caused by the zoonotic parasite Trypanosoma cruzi. CD can be transmitted orally by consuming drinks that are made with vegetables or fruits and are contaminated either by triatomine feces or by secretions of infected mammals. Acute myocarditis, heart failure, meningoencephalitis, and prolonged fever are caused by oral infection. Due to this 30 %, mortality can occur. Human migration is a potential factor that increases the risk of CD from endemic to non-endemic countries. CD has become a…

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    Mrs. White’s COPD is triggered mainly by her history of cigarette smoking. The noxious substances in cigarette smoke initiate the production of Tumor Necrosis Factor-a (TNF-a) and release of inflammatory mediators by macrophages and epithelial cells. In fact, the activated cells in COPD inflammation secrete a number of mediators. These include a variety of active proteinases, toxic peptides, and oxidants which damage lung structures and sustain inflammatory processes (_____). The resulting…

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    Nephrotoxicity is associate adverse effect of the anticancer drugs for solid and hematologic malignancies (Kintzel, 2001). Cisplatin, cisplatinum or cis-diamminedichloroplatinum (II) , a platinum-based drug, is one of the most frequently used anti-neoplastic agents. It has a potent anti-tumor action against wide range of malignancies, including testicular, ovarian, cervical, bladder and lung cancers as well as solid tumors resistant to other treatment regimens (Hanigan and Devarajan, 2003).…

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