Insulin resistance

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    Introduction What is Insulin Resistance Syndrome? Insulin Resistance Syndrome is a proven facilitator of an alarming number of chronic illnesses in the United States. In order to understand the severity of insulin resistance syndrome, it is vital to recognize the important role that insulin plays in the human body (Reaven, 1995). Insulin is a hormone produced by the pancreas which is instrumental in the body’s use of digested food for energy. The body’s digestive tract breaks down carbohydrates consumed into glucose which enters the bloodstream. Insulin aids the cells in the body to absorb and use glucose for energy. Insulin resistance occurs when the body’s cells do not react appropriately to insulin which makes it difficult to absorb glucose…

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    Strong evidence suggests an association between Alzheimer’s disease (AD) and insulin resistance [95]. De la Monte is one of the leaders who proposed the concept of Type 3 Diabetes Mellitus (T3DM) or brain insulin resistance based on experimental studies which demonstrated that brain insulin resistance in Alzheimer patients can be identified as type 3 diabetes (T3DM) [95, 96]. T3DM (brain insulin resistance) has molecular and biochemical features that overlap with both type 1 diabetes (T1DM) and…

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    Glucocorticoids Essay

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    The prolonged use of therapeutic glucocorticoids is associated with a range of adverse effects (figure 1). The detrimental effects on bone have received the greatest focus and there are now a range of therapeutic strategies available to reduce the negative effects of glucocorticoids on bone [1]. Endogenous or exogenous glucocorticoid excess is also associated with other serious clinical features such as the development of insulin resistance, impaired glucose tolerance and frank diabetes [2].…

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    early diagnosis, proper education and good care during pregnancy decrease risk factors and promote a healthy life and outcome for baby and mom. What is PCOS? When a woman is affected by PCOS, small cysts develop on her ovaries. These multiple (poly) cysts cause hormonal imbalances. The male sex hormones, androgens, (present in small amounts in women) increase. Also, the body tends to become insulin resistant. The results of PCOS include issues with menstrual cycles and…

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    Body weight (P=0.003), whole body fat mass (P<0.001), and waist circumference (P=0.003) also showed significant reduction with both group compare to baseline, but there was no statistically significant difference between the groups. Adverse event with liraglutide were nausea and diarrhea that did not correlate with weight loss and improved over time. The author of the study concluded that liraglutide did not show statistically significant weight loss difference between metformin, but have…

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    (van Uffelen et al., 2010) The list of serious sedentary health issues relevant to office employees due to the decrease in active work and the increase of sedentary activity are summarized in Table 2. Figure 1: Adult Activity Distribution during Waking Hours Figure 1. Distribution of adult activity during their waking hours. Adapted from “Too much sitting: a novel and important predictor of chronic disease ?” by N. Owen, A. Bauman, and W. Brown, 2009, British Journal of Sport…

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    1. The purpose of the study was to evaluate the effectiveness of the MEND (Mind, Exercise, Nutrition, Do it) program. 2. The study was set up as a randomized control trial. There were a total of 117 participants recruited, of which – 116 were randomized. Of the randomized participants, 60 were recruited into the intervention trial, while 56 were placed into the control group. 3. The MEND intervention program focuses on cultivating healthy nutrition, behavior, and exercise habits within…

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    found that BBP was able to bind to Sert-3. Dr. Choundhury found that BBP disrupts the insulin regulatory pathway by binding to the native ligand of the receptor of a protein that causes insulin to be produced. Insulin helps facilitate the uptake of glucose into muscles and adipose (fat cells) for storage. If insulin is unable to uptake glucose, it will cause for the stimulation of fat in adipose tissue, which can cause obesity and diabetes. BBP was also found to induce adipogenesis. The…

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    Diabetes Mellitus Type 2 is a complex chronic metabolic disorder characterised by increased insulin resistance and impaired insulin secretion by pancreatic beta cells and involving an interplay of various genetic and environmental factors. This report discusses the pathogenesis and long term complications of type 2 diabetes as well as several pharmacological treatments. Pathogenesis of Type 2 Diabetes
Genetic predisposition contributes to the pathogenesis of Type 2 diabetes as evidenced by a…

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    characteristic to determine insulin resistance syndrome and metabolic syndrome; the theory underlines that increased visceral tissue cause rise in the change of free fatty acids and inhibits insulin action via Randle’s effect in insulin-sensitive tissue. Number of different studies (Carey et al 1997; Wei et al, 1997; Balkau et al, 2007) have indicated that the central obesity can be measured by waist circumference or wait-hip ratio. A waist circumference of > 94 cm for white and black men,…

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