RNA virus

In sequence 1, the protein that the DNA sequence coded for was Presenilin 2, also known as PSEN2. These proteins are developed from directions from the Presenilin Gene. One of the jobs of PSEN2 Gene is to process proteins that transmit chemical proteins from the cell membrane into the nucleus. From there they can activate genes, critical to cell growth and maturation (What is the normal function of the PSEN2 gene ). Processing amyloid precursor protein is also one of the main functions of PSEN2.…

The APOE gene, located on chromosome 19, is a gene that helps in the creation of apolipoprotein E to help to form molecules called lipoproteins, this protein forms the lipo-proteins by combining with lipids in the body. By forming lipo-proteins, apolipoprotein E participates in the responsibility of managing cholesterol and carrying it, and other fats, through the bloodstream. By maintaining cholesterol, it helps to act as a prevention against disorders that can hurt the cardiovascular system,…

constraints of this section resulted in a relatively information-dense description. Nevertheless, as Dr. Glaunsinger explained her research, the audience could clearly understand that her work aligned with her broader goals of understanding the DNA virus interactions with mammalian systems. Importantly, the data presented during this section smoothly transitioned to the conclusion which summarized her story, emphasized the broader goals, and eluded to open questions that currently exist in this…

Alkaline phosphatase (AP) is a homodimeric enzyme complex that is commonly found in a wide range of organisms, from bacteria to all tissues of the human body. AP is a zinc metalloenzyme (1), in which metal ions play a key role in the regulation of catalytic activities and stabilization of enzyme-substrate complex. As proposed by Gettins and Coleman using NMR studies (10), each active site of AP comprises of three metal binding sites, which acknowledged as M1, M2, and M3. Two zinc ions bind to…

a template for RNAs capable of recognizing viral DNA within a cell and as a means to bind the endonuclease CRISPR associated protein 9 (Cas9). These complexes allow the enzyme to be shuttled to the target DNA to perform a cut on one or both strands of the foreign DNA in either of the enzyme’s two active sites. Recently, scientists have repurposed this bacterial defense mechanism as a genome editing utility to cut, shuttle, or bind desired molecules anywhere within DNA as custom RNA harnesses the…

Under oxidative conditions, certain nucleobases (for example, adenine and cytosine) can form N-oxides. Also, the C8 position of guanosine is vulnerable to hydrolytic attack under either strongly acidic or strongly alkaline conditions. The 5,6 double bond of pyrimidine nucleosides also reacts with halogens and halohydrins to give the corresponding addition products (Shabarova and Bogdanov, 1994). Selected examples of the side reactions that occur during oligonucleotide synthesis are given below.…

Leroy et al. (2000) used 4 microsatellite primers to characterise Brassica oleracea accessions. Among the 136 reproducible fragments generated, 25 (18.4%) fragments were common for all Brassica, 27 (19.9%) were unique and 84 (61.7%) were phylogenetically informative. Flannery et al. (2006) assessed polymorphisms in Brassica, Arabidopsis, Camelina, Raphanus and Sinapis using 10 plastid SSR primer sets. Eight loci were polymorphic, and separated the individuals of Brassicaceae into taxon-specific…

As aware of by most, one of the leading diseases that is causing a threat to our society currently is cancer. The prevalence of this disease is overwhelming and the treatment is possible; however, there is still need for further investigation into the cause of this disease before ¬¬¬¬¬it is thoroughly understood. Through increasing research there has been a connection made that cancer is the result of cells that continually replicate and causes for neoplasm to develop at an alarming rate (2).…

The cyano-ethoxy carbonyl protection Manoharan et al. (1999) developed 2(cyanoethoxycarbonyloxy)succinimide S.27a a stable, crystalline, and convenient reagent for the protection of pendant akylamines in oligonucleotides (Figure X.X.X). The 2-cyanoethyl (ce) group is the most common phosphate protecting group in oligonucleotides; however, ce and corresponding 2-(cyanoethoxycarbonyl) group were not utilized for the nucleobase protection until 2000. Merk et al. (2000) developed…

Protein structure prediction is that the prediction of the three-dimensional structure of a protein from its organic compound sequence — that's, the prediction of its folding and its secondary, tertiary, and quaternary structure from its primary structure. Structure prediction is essentially totally different from the inverse downside of protein style. protein structure prediction is one among the foremost necessary goals pursued by bioinformatics and theoretical chemistry; it's extremely…