Protecting group

a silylating agent, and the acyl function is installed on the amino group using the corresponding acid chloride or acid anhydride. (3) Some acyl functions such as benzoyl, α-phenylcinnamoyl, and naphthaloyl are directly incorporated on the nucleobase using the corresponding anhydride (Watanabe and Fox, 1966; Bhat et al., 1989). Zhu et al. (2003) reported an improved synthesis of N-benzoylated nucleosides by reducing the amounts of chlorotrimethylsilane (TMSCl) and benzoyl chloride to nearly equivalent quantities. The major advantage of this method is the easier work-up and higher yields. The original method by Ti et al. (1982) was further simplified by eliminating the addition of ammonium hydroxide. (4) The exocyclic amino group of cytidine and deoxycytidine were directly acylated using activated esters (Igolen and Morin, 1980), acid chlorides (Mishra and Misra, 1986, and references therein), or alkyloxycarbonylbenzotriazoles (Himmelsbach et al., 1984). (5) Site-selective incorporation and removal of N-acyl protecting groups have also been achieved by enzymatic methods (Prasad and Wengel, 1996). (6) Selective acylation of nucleosides has also been carried out by N-acyltetrazole (Bhat et al., 1998) and carboxylic acids activated in situ with carbonyldiimidazole (Sinha et al., 1995). (7) N-Benzoyltetrazole has been developed as a mild and selective reagent for the monobenzoylation of the exocyclic amino groups in adenine and cytosine nucleobases (Bhat et al., 1997). In a…

We would like to start by introducing our group which consists of Salome Fregoso, Roxanne Wagstaff, Andrea Lopez, Mehwish Kazi and Angel Mejia, we named our group the Avengers. For our first group assignment we were asked to pick a topic from the three provided on blackboard. We chose option one which is about theories. Our assignments were to interview three parents of children ages 12 months - 5 years and ask them to share some stories about their children and about themselves when they were a…

Architectural elements harmonize and organize architecture. Without order confusion can set in, using architecture elements and principles there will be order and harmony. An architect uses these methods to create an emotional and balanced design. Case studies chosen to analyze are Howard House in West Pennant, Nova Scotia designed by Brian MacKay-Lyons, second chosen was the B2 House in Ayvacik, Turkey by Han Tumertekin. Both buildings have elements and principles of architecture that will we…

Demonstrated through creation of flashcards by accurately writing the product of the fact shown and on assessments. CC.2.2.3.A.1 Represent and solve problems involving multiplication and division. Creation of multiplication problems through game activities 10.5.3.F Recognize and describe game strategies using appropriate vocabulary. I was working with third grade standards because understanding multiplication chart begins in third grade and all students should and need to be proficient with…

With everything going on I forgot that still, no one said a word. The only people speaking were the people already in the OA. That morning, we were all separated into groups, and we were all assigned jobs. I didn’t know much about the jobs other groups were assigned, but mine was assigned to trail work. Within no time, we were off to work on our tasks. My group started off on one of the trails. Whenever we saw brush creeping into the trail, it was our job to remove it. It started off fairly…

Daily we are introduced to situations where the ability to mentally rotate an object or an image comes to good use. For example, imagine you are playing a game of Tetris. As the object is rapidly moving down your computer screen you have to mentally rotate it in order to see where the piece would fit best. In another scenario, imagine you are given a map to find directions around a city. After you locate yourself on the map, you next have to mentally rotate the map or yourself to decide which…

Clinical Reflection: Group Meeting I arrived thirty minutes earlier for the meeting scheduled at seven that evening, but the parking lot was almost full and teeming with activity. There were people talking, laughing, and some were loitering, wandering aimlessly before proceeding through a discreet door; ten minutes prior to the scheduled start. Hence, the scene reminded me more of an enthusiastic crowd being ushered in before the movie start or an eager bunch queueing up for the latest…

The research everyone had collected installed much needed confidence that this group will do well. All of our assigned task were completed on time and throughout the week there was increased communication between members. Here you could see the process of Norming becoming reality as everyone began to socialize and were more comfortable with each other. There has been a degree of personal difficulty and sort of a personal joke for me. On week one my desk top computer died on me, on week two…

Romark is a distribution center that cannot be simply seen as a warehouse. They get the finished goods from manufactory, packaging and storing the goods in the warehouse temporarily. They have public and contract warehousing options to meet the need of their different customers. They also provide the shipping services. First of all, they have good hardware facilities. They have good vehicle and good warehouse. They have shuttle and good truck to move their inventories. Their truck and warehouse…

I ended up having more B-mode statements than any other mode. The book says that, “[t]hose with more B-mode responses base their self-concept on group membership and institutional roles” (pg.136). It also says that if you give yourself more B-mode statements, then it is possible that C-mode is dominant while in the classroom. “C-mode responses see themselves as more independent and define themselves according to their individual actions and emotions rather than connections to others” (pg.136).…