RNA splicing

    Page 1 of 14 - About 139 Essays
  • Analysis Of GUK1 Result

    Differential alternative splicing human tissue network analysis of GUK1 Result Figure 4.12: Visualisation of alternative splicing gene GUK1 in human tissues. Differential alternative splicing genes between two different tissues comparison were shown on a different visualisation platform and tools in comparison with network analysis. (A) rMATS analysis. Histogram shows inclusion level ψ, per sample for each tissue comparisons. In this case, only exon 3 found as statistically alternative splicing significance of skipped exon (SE) in both tissue comparisons; heart vs. liver and brain vs. liver. The inclusion level in the heart is 0.9 and 0.35 in the liver for tissue comparison heart vs. liver; while inclusion level in the brain is 0.83 and 0.28…

    Words: 2010 - Pages: 9
  • Central Dogma Of Molecular Biology

    Possible Modifications of Central Dogma of molecular Biology Introduction The central dogma of molecular biology is describes the transfer of genetic information within a biological system and was first stated by Francis Crick in 1956. The central dogma is the flow of genetic information as ‘’DNA makes the RNA and RNA makes the protein.’’All biological cells with few exceptions in some follow this rule. This flow takes place through three fundamental processes: replication, transcription and…

    Words: 1509 - Pages: 7
  • Proteins: Large, Complex Macromolecules In Organisms

    The ribosome reads information along the mRNA and brings the amino acid together with help from transfer RNA. Transfer RNA has a cloverleaf shape with base-paired arms and an attached anticodon sequence. At the bottom of the tRNA there is an anticodon that pairs with a codon on mRNA. A codon is a sequence of three nucleotides. Codons are read, in order, by tRNA, which aligns with the codon and attracts the corresponding amino acid. It continues this same cycle, connecting amino acids, to make a…

    Words: 1470 - Pages: 6
  • Pancreatic Adenosquamous Carcinoma Case Study

    Significance Pancreatic adenosquamous carcinoma (ASC) is a rare but aggressive tumor, with higher metastatic potential and an even worse prognosis than pancreatic adenocarcinoma[1, 2]. A major hindrance towards development of therapies against pancreatic ASC is that the molecular mechanisms underlying its pathogenesis remain poorly characterized. In this proposal I will take advantage of the expertise on RNA biochemistry and molecular biology that I have acquired during my doctoral training and…

    Words: 1024 - Pages: 4
  • Gene Regulation Research Paper

    plentiful. The polycistronic mRNA encodes for the enzymes of tryptophan biosynthetic pathway. Binds strongly to the operator, blocking access of RNA polymerase to the promoter and keeping the operon repressed.  Prokaryotic gene regulation: regulation of the lac operon, which control promotion and repression. Control of genetic is elucidated method of milk sugar known as lactose. Analytical catabolism in the human symbiote Escherichia coli. The lac operon includes three structural genes. (LacA,…

    Words: 1325 - Pages: 6
  • Pancreatic Adenosquamous Carcinoma Case Study 1

    examine the differentially expressed candidates in pancreatic ASC, I will isolate total RNA from UPF1 mutant cell lines and perform RNA sequencing. To establish whether the upregulated genes are direct targets of NMD, I will compare this data with RNA isolated from cells where UPF1 is downregulated using short hairpin RNAs. To validate the top targets from RNA sequencing experiments, I will perform qPCR and northern blotting. To examine whether these candidates are also altered in pancreatic…

    Words: 1047 - Pages: 4
  • Eukaryotic Synthesis

    Transcription is considered to be the first step of gene expression. It is known to be the process of making a copy of genetic information stored in a DNA strand into a complementary strand of messenger RNA (mRNA). The process of eukaryotic transcription can be separated into three phases, initiation, elongation and termination. This complex process involves various cell signaling methods as well as the activity of many enzymes. Genes are segments of DNA nucleotides located on a chromosome…

    Words: 1359 - Pages: 6
  • Fto Synthesis

    FTO belongs to a member of Fe(II)- and α-ketoglutarate-dependent AlkB dioxygenase family and was originally recognized as an enzyme involved in the excision of N1- or N3-modified purine or primidine in both DNA and RNA substrates. Jia et al. for the first time demonstrated that human FTO could also demethylate m6A on nuclear RNAs in vitro, and increase and decrease in m6A was manifested in FTO-depleted and overexpressed-HeLa cell, respectively. FTO function has shown to link to the regulation of…

    Words: 990 - Pages: 4
  • Alkaline Phosphatase Research Paper

    Alkaline phosphatase (AP) is a homodimeric enzyme complex that is commonly found in a wide range of organisms, from bacteria to all tissues of the human body. AP is a zinc metalloenzyme (1), in which metal ions play a key role in the regulation of catalytic activities and stabilization of enzyme-substrate complex. As proposed by Gettins and Coleman using NMR studies (10), each active site of AP comprises of three metal binding sites, which acknowledged as M1, M2, and M3. Two zinc ions bind to…

    Words: 764 - Pages: 4
  • Protein Structure Hypothesis

    so much behind the buildup of protein sequences. By the end of 2007, there have been forty four,272 protein structures deposited within the protein data Bank (PDB) SECONDARY STRUCTURE: Secondary structure is that the native arrangement of a polypeptide’s backbone atoms while not relevance the conformations of its aspect chains.It is a group of techniques in bioinformatics to predict the native secondary structures of proteins and RNA sequences based mostly solely on data of…

    Words: 1774 - Pages: 8
  • Previous
    Page 1 2 3 4 5 6 7 8 9 14

Related Topics:

Popular Topics: