In vivo

evaluation of small molecules as anti-proliferative agent to combat the cancer disease. This project allowed me to acquire a greater knowledge of a variety of skills and approaches required in this field of scientific research, such as In vetro and In vivo biological studies in order to evaluate the pharmacological activity. In addition, molecular modeling, microwave-assisted chemical synthesis, spectroscopic techniques, separation, purification…

reported in 1980 that various growth factors could stimulate the migration of keratinocyte and thus could mediate the regeneration of damaged skin [29]. TGF-b1 is one of the important growth factor that plays a crucial role in skin regeneration. In vivo study on rats also revealed the potential of TGF-b1 in promoting the healing process of injured skin, increasing the collagen deposition and improving the tensile strength of skin wounds. Moreover, studies of transgenic and gene knockout mice…

Currently, Dr. Rong Lu conducts research at the University of Southern California (USC). Her lab investigates stem cell malfunction, regulation, and coordination at the single cell level (1). Furthermore, she uses mouse hematopoietic stem cells (HSCs) as a model system (1). Dr. Lu’s research utilize various disciplines of biology such as molecular, cellular, and systems biology (1). Additionally, Dr. Lu’s research focuses on investigating the differences and coordination between individual stem…

1. The authors studied this topic to investigate if the cohesion complex has any influence on chromosome instability and if it does, how to correct it. This is important because chromosome instability is proposed to be a major contributor to the acceleration of cancer cell evolution1, and as a previously overlooked source, cohesion fatigue can induce chromosome instability. The authors focused on the cohesion complex in this study since in a previous study they identified that a certain protein,…

Nuclear magnetic resonance (NMR) spectroscopy and imaging can be used to investigate, noninvasively, a wide range of biological processes in systems as diverse as protein solutions, single cells, isolated perfused organs, and tissues in vivo. It is also possible to combine different NMR techniques enabling metabolic, anatomical, and physiological information to be obtained in the same experiment. This review provides a simple overview of the basic principles of NMR and outlines both the…

The idea that synaptic modifications in the brain underlie learning and memory was first hypothesized by Donald Hebb in his pivotal work The Organization of Behaviour: A Neuropsychological Theory (Hebb, 1949). Since then, the theory has gained strong support from various lines of research where the discovery of synaptic long-term potentiation (LTP) and long-term depression (LTD) within the mammalian hippocampus present the strongest line of evidence (Howland and Wang, 2008). These phenomena have…

experiments were aimed at finding how SOD1 becomes pro-apoptotic (promoting programmed cell death) due to the fact that healthy SOD1 are against programmed cell death (Pasinelli et al. 2004). The pro-apoptotic characteristic of mutant SOD1 is demonstrated in vivo and in vitro. The mitochondria inside cells firmly control apoptosis, and the mutant SOD1 that aggregates inside mitochondria triggers the programmed cell death of motor neurons (Pasinelli et al. 2004). One experiment studied proteins…

every 100 grams of fertilized duck egg (Table 2) (Jalaludeen & Churchill, 2006). Proteins aid in the cultivation of various bacteria whereas it is one of the basic growth components in bacterial cultivation. Moreover, the presence of cholesterol in vivo aids in nurturing bacteria and allow it entry into host cells. (Tille, 2013). Table 2 Nutritive Value of Duck egg compared to Chicken egg. (http://www.poultryline.com/issues/oct/duck%20eggs%and their…pdf) Carbohydrates Using Avocado…

Craniofacial defects such as cleft lip and cleft palate which occur as an isolated condition, or may be one component of an inherited disease or syndrome are among the most common of all birth defects. Cleft lips and palates are frequent congenital craniofacial malformations, with an incidence of 1.5-2.5 per 1,000 live births. Children who have an orofacial cleft require several surgical procedures. Most large defects, also known as critical bone defects are successfully treated with allogenous…

Osteoarthritis is a disease of joints that means they do not move as smoothly as they should be, due to the thinning of the cartilage [1]. This disease mostly affects people over the age of 65, and it is estimated that 2.46 million people suffer from osteoarthritis in England alone, just of the hip joint. Osteoarthritis causes a lot of pain to the patient and a loss of mobility due to the damaged joint. It has been found that joint replacement offers significant pain relief and improvement in…