In vivo

In the drug development procedure, Good Laboratory Practice stand at the Preclinical Development Stage, also called as a non-clinical stage as it is not conducted in human. Its main goal is to test the safety. Toxicology, Pharmacokinetics Pharmacodynamics and bioavailability studies must follow the GLP compliance.Good laboratory practice (GLP) was first announced in New Zealand and Denmark in the year 1972 and later in the USA in June, 1979 as regulations passed to stop investigators who submit…

(2006) also analysed the in-vivo effect of cinnamon extract on blood lipid levels. According to the results, the use of cinnamon extract was associated with a significant increase in high density lipoprotein concentrations as well as a lower level of triglycerides after six weeks…

parent-child sessions into different components of treatment through the PRACTICE Model: Psycho-education and Parenting Skills; Relaxation Skills; Affect Expression and Regulation Skills; Cognitive Coping Skills and Processing; Trauma Narrative; In Vivo Exposure; Conjoint Parent-Child sessions; Enhancing Safety and Future Development (Cohen & Mannarino, 2008). In addition, there are homework activities that can be assigned each week for the client and the parent to practice learned skills at…

Systematic desensitization is a technique based on behavioral principles that used to treat phobias or anxiety disorders; also called graduated exposure therapy. The technique is supposed to pair an anxiety event with a stimulus that elicits an opposing response, such as relaxation, relaxed muscles and coping techniques. This is also what psychologists call counter conditioning. In order for the person to identity what is causing the anxiety; one must identify the specific factors that are…

Interventions Cognitive behavioral therapy or CBT focuses on the thinking and behaviors that that lead to depression and anxiety. This therapy will address these patterns through several interventions that are intended to change and alter these thoughts and behaviors that contribute to your unhappiness. We will look at thoughts that are unhelpful and lead to your depression and social anxiety. By following the treatment plan and fully engaging in the interventions the goal is to reduce the…

RESULTS SOLUBILITY ANALYSIS: Ketoprofen sample was found to be soluble in ethanol, Chloroform, ether, acetone at neutral pH and is found to be almost insoluble in water. Solubility analysis is important because the drug has to dissolve in the solvents and also in the dissolution medium used. MELTING POINT DETERMINATION: The melting point of the Ketoprofen was found to be 96˚C by open capillary tube using microcontroller based melting point apparatus which is within the reported range of 94˚C…

predict [4]. Gene knockout strategy is a very powerful tool in industry [5] to study the function of a gene in the most effective way and can be relatively easily achieved in most cell types by using either in vivo or in silico methods. However, using gene knockout strategy in wet lab (in vivo) often faces the issues of highly cost and time consuming. Therefore, in silico technique for metabolic engineering has been developed to overcome this problem. In silico technique usually has computing…

polymethyl-methacrylate (PMMA) and graphene, have been used in other biomedical applications, the host response to the device is highly predictable. Various options for sterilizing the device will be assessed. The tests will be performed in vitro and in vivo before proceeding to clinical trials in order to submit for and gain FDA approval. In order to assure the quality of a device intended for surgical implementation, it must be sterilized—that is, deficient of all living…

First, hematotoxicity is the study of blood and blood-forming tissues as a target organ for drugs or different chemicals. It is the toxic effect that the substance has on the properties or components of blood. Additionally, other factors to include when determining toxicity are stress, exercise, and ionizing radiation. Furthermore, blood and hematopoietic tissue are target organs for scrutiny and the study in preclinical and clinical safety evaluations. There are several methods that…

Scholarly scientific journals and peer-reviewed journals are often viewed as credible sources that other scientists or researchers make references when writing their own dissertations or research reports. However, in order to gain credibility from academia, it is essential to follow certain guidelines and organization when writing a scientific paper. From the given scientific paper, Cytotoxic Activity of Biosynthesized Gold Nanoparticles with an Extract of the Red Seaweed Corallina officinalis…