SOD1 Case Study

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Some experiments were aimed at finding how SOD1 becomes pro-apoptotic (promoting programmed cell death) due to the fact that healthy SOD1 are against programmed cell death (Pasinelli et al. 2004). The pro-apoptotic characteristic of mutant SOD1 is demonstrated in vivo and in vitro. The mitochondria inside cells firmly control apoptosis, and the mutant SOD1 that aggregates inside mitochondria triggers the programmed cell death of motor neurons (Pasinelli et al. 2004). One experiment studied proteins that interact with mutant SOD1, specifically Bcl-2 which is anti-apoptotic, in order to explain the apoptotic nature of mutant SOD1 (Pasinelli et al. 2004). The methods that were used involve in vitro approaches and Western blot analysis. The outcomes …show more content…
2004). This vacuolization only occurs at the onset of the disease, and disappears toward the terminal segment (Kong and Xu 1998). Also, early vacuolization affects the life of motor neurons in a dangerous manner, and coincides with the foundation of muscle weakness (Pasinelli et al. 2004). Vacuolization is a prominent feature of amyotrophic lateral sclerosis, and occurs before any muscle weakness or cell death ensues; this could be an early detector of the disease, and help scientists push toward further research on the mitochondria of patients with ALS. Comparable information throughout the various research on vacuoles inside mitochondria demonstrates that it is an important characteristic of the disease, and is the primary initiation of the degeneration of the

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