DNA repair

For my project, I chose to make an illustration. In the picture I have a breast cancer ribbon, a pot of boiling water, a prokaryote, a chromosome, a pedigree, and a factory to represent human impact, a flower to represent photosynthesis, a food chain, an energy pyramid, an embryo, humans evolving, a biomolecules chart, and the phases of mitosis. I drew a breast cancer ribbon because we talked about different types of cancer. There are many factors that go into the diagnosis of cancer. A lot of…

trying to figure out how to alter human DNA to enable us to repair or regrow our own cells, tissues and organs as well.…

The Effects of Technology on Biomedicine Dontae Weatherly CRN: Submitted [date and time] The Effects of Technology on Biomedicine INTRODUCTION Biomedicine is a branch of medical sciences that ties biology and clinical practice together. Biomedicine or medical biology is a major facet of modern health care and lab diagnostics. Biomedicine and biotechnology go hand in hand, with that being said, technology has a great impact on the advancement of biomedicine.…

the current study, the effect of nilotinib, a marketed drug used by human beings that has a well-defined safety profile, was investigated on APAP-induced hepatotoxicity in mice. Nilotinib treatments for mice were found to protect against APAP-induced liver injury as indicated by decreasing the elevated levels of serum ALT, AST, LDH and GGT activities. The protective effect exerted by nilotinib against APAP-induced liver injury was further confirmed histopathologically by preventing APAP-induced…

Last Ape Standing by Chip Walter “It is easier to build strong children than to repair broken men.” – Frederick Douglass During the course of evolution different kinds of humans have always been challenged by nature and were forced to adapt. In his book “Last Ape Standing” Chip Walter tries to explain thoroughly how we are the only remaining human species that inhabits our planet right now and why so many others vanished from the face of the earth in the last seven million years. Only the best…

implications with regards to leukemogenesis; the mutant version of the latter has been commonly associated with leukemia. MEF/ELF4 is part of a family of transcriptional factors (ETS) responsible for numerous cellular functions, such as genomic stability, DNA repair, and most importantly, the regulation of cell proliferation, differentiation and cell death. In particular, MEF/ELF4 is expressed in hematopoietic cells in order to control their movement through the eukaryotic cell cycle, thus…

Parents want the best for their children, so it is understandable that they want them to have the best set of DNA, but modifying the child to their liking, is it really what is best for the child? Their decision is based on their preferences and not on the child’s. It is the child that will live with the genetically modified characteristics for the rest of their…

cardiac cells without any pathogenic effect and therefore, they are used commonly to insert genes into cells. Cas9 or CRISPR associated protein is a protein that acts as the molecular scissor and cut the DNA in the desired site and thereby editing the gene. The DNA is not withered away rather it gets repair by our cells. During the repairing process some nuclear base are added (inserted) or deleted or gets exchange with a nuclear base that suddenly ends a protein translation. This insertion and…

Defining DNA Ligase IV Syndrome There are several enzymes that are essential in DNA replication and repair. Yet the human body can at times malfunction causing a disease related to the mutation of the enzyme. One such enzyme is ligase. As stated in the text, Genetic Essentials by Pierce, in ideal circumstances ligase is the “enzyme that catalyzes the formation of a phosphodiester bond between adjacent 3’-OH and 5 -phosphate groups in a DNA molecule” (2013, p. A4). Yet if this does not occur,…

severe distortions in the conformation of DNA at the mismatch site occurs. The clamp has numerous hydrophobic and charged residues, which is consistent with a role in dimerizing with the charged residues of the clamp of MSH6. In addition, it may work to stabilize the highly unfavorable state of DNA when a mismatch is recognized. The positively charged residues such as lysine and arginine can form ion pairs with the negatively charged phosphate groups on the DNA backbone. Furthermore, the…