Neurodegeneration

emergence chronotypes in fruit flies Drosophila melanogaster." Journal of biological rhythms (2014): 0748730414553797. Prüßing, Katja, Aaron Voigt, and Jörg B. Schulz. "Drosophila melanogaster as a model organism for Alzheimer’s disease." Molecular neurodegeneration 8.1 (2013):…

Anthony Alvarado Bio 1A Chronic oxidative stress via hydroxyl radical and imbalanced redox homeostasis Redox hemostasis has been shown to be an important factor in the overall aging and neurodegeneration processes in mammalian models; such as, Alzheimer’s and Parkinson’s. As a result, redox homeostasis has been a key point of interest in current research. Redox homeostasis is the balance between electrophiles and nucleophiles in a system, more importantly in a biological system. These…

(MBP), myelin-associated glycoprotein and neurofilament (NF) are reported to be associated with arsenite toxicity. It also upregulate vacuolated axons, especially those are present in the corpus-callosum region [31]. Oxidative stress associated neurodegeneration have been reported as the result of arsenic toxicity [32]. This is evident in our present investigation. Since, cerebral and cerebellar DNA is found to be less interfered by arsenic so the arsenic-induced toxicities are mostly…

Picture a sponge. A common household item that is very simple yet useful. Now compare that sponge to the human brain. It’s porousness allows outside substances to seep in and be collected. The sponge grows and holds more than expected of it. Much like the sponge, our brain can absorb and retain valuable resources. Without the brain, humans would not be able to function. The brain, a highly complex part of the human anatomy, is in charge of one’s intelligence, the senses, producer of all body…

substrates in multiple cellular pathways and abnormalities: CHIP substrates form a large group of proteins, implicated in various important pathways and pathologies. Substrates are subdivided in accordance with their association with cancer, neurodegeneration, signaling, transcriptional regulation, and development. Substrates have been put into different boxes according to their degradative pathways. Yellow boxes represent substrates, which are degraded by the proteasome, whereas brown boxes…

General Overview of CTE: Chronic Traumatic Encephalopathy (CTE), a condition characterized by progressive neurodegeneration of the brain, was first diagnosed by Dr. Bennet Omalu in 2002. CTE affects those who have suffered multiple and repeated brain injuries, such as athletes of high contact sports and veterans of war and is only able to be diagnosed post-mortem. For example, much research has been centered on athletes that play football in the NFL. It is reported that over 90% of players who…

progression of behavioural and biochemical changes induced by oxidative stress. Restraint stress produces an imbalance between oxidants and antioxidants, which are the major cause for the pathogenesis of various neurodegenerative diseases. Oxidative neurodegeneration is a key factor in worsening the morphological responses and deficits in behavioural recoveries. Stress is known to elevate circulating…

It’s interesting to see the progression of weapons from the early beginnings to now. Most people believe that chemical warfare agents were first introduced during the World Wars. Interestingly enough, the concepts of these agents were developed as early as 600 B.C. They weren’t known as chemical warfare agents however; the techniques that were used mimic the action of these agents that are being used today. During the Peloponnesian War between Sparta and Athens, the Spartan army used a mixture…

“Football is a great deal like life in that it teaches that work, sacrifice, perseverance, Competitive drive, selflessness and respect for authority is the price that each and Every one of us must pay to achieve any goal that is worthwhile.” — Coach Vince Lombardi Sports has been an intricate part of cultures and societies in many different ways dating as far back as to prehistory. In fact, the first Olympics can be dated back to 776 BC taking place in Olympia, Greece. Sports have been…

abnormalities. One such disorder is Maple Syrup Urine Disease (MSUD) otherwise known as Branched-chain Ketoaciduria, a dangerous condition in which over saturation of amino acids in the blood can lead to toxicity progressing to encephalopathy, neurodegeneration, coma or respiratory failure (Haldeman-Englert, 2015). MSUD results from a malfunction of the branched-chain alpha-ketoacid dehydrogenase complex (BCKD) (Kniffin, 2013). This complex produces enzymes necessary for the proper breakdown of…