Lysosomal storage disease

the continuous pumping of hydrogen ions into the cell, allowing for lysosomal hydrolases to carry out optimal function. Lysosomes act as the digestive agent within the cell breaking down cellular waste, proteins, fats, and carbohydrates into simpler molecules…

Gaucher Disease In 1882 a French physician, Philippe Charles Ernest Gaucher, first discovered Gaucher disease in a 32 year old woman; she had a swollen liver and spleen. Gaucher disease is a genetic disease meaning it is an abnormality in an individual’s DNA. Gaucher disease (GD) is described as an inherited disorder known to affect many of the body’s organs, such as the liver, spleen, bones, bone marrow and in severe cases the brain. It is also the most common lysosomal storage disease.…

Pompe Disease is also referred to as GAA Deficiency, Glycogenesis Type II, and Glycogen Storage Disease Type II. It is a lysosomal storage disorder that must be passed down by both parents due to the fact that it is a recessive mutation in genes (Type II, 2014). As a lysosomal disorder, Pompe Disease is the inability of lysosomes to breakdown glycogen into glucose and causes the glycogen to build up inside the lysosome (Pompe, 2010). The glycogen build up has specific effects on the muscles…

calculated as follows with the information provided. Average pallet inventory 2441 Average unit inventory 732346 Peak pallet inventory 3051 Effective pallet storage capacity 2746 Required number of pallet storage locations 3231 Floor space requirements 87235.4 2. Multi-use warehouse in which cross-docking, case picking, and broken case picking operations occur. WAREHOUSE LAYOUT In the above warehouse layout, I considered the space available to design as 100% and the percentage…

The human memory is an inaccurate storage of our lives, memories are often revised, cut out, or replaced. Jim’s experience with incorrectly recalling the day his parents won the lottery can be due to many different ways the brain forgets information. Jim may know that his parents won the lottery but not have enough paid attention to the specific details of the day. This occurs often with exciting events, you focus so much on what is happening we do not remember particular details. This…

it’s completely harmless." explained the old man. You took a look at it again. "What does it do? But I know it could cuts off the heads." you questioned. "But it won 't just cut heads off, but it can cut any part unharmed." he answered. So you got confused. "So... It won 't spread any blood out?" you ask, confused. "Nope, it doesn’t." Now you want to buy it, he said it cost 600,000 Pokedollars (Means 6,000 dollars). You bought it. "Thanks. I guess?" you said. "One moment please." An old man…

McLaughlin stated there was a Ryobi pressure washer in the west corner of the room which was taken also. It appeared that the suspects attempted to gain entry through the garage door which was ajar. There were pry marks located on the door of the storage room. After obtaining the information regarding the missing items in the storage room, I relocated to the pantry room. Prior to entering the room, I observed the locking mechanism on the door broken and the door frame split open. Inside the…

So, the first week I got yelled at by another business owner for parking on the wrong side of the street. When I was shown the storage room, you just pointed out the items in the room, instead of walking me up to each one. When being shown around the building I was not shown the big garages in and out of the building or the main storage rooms we allow the customers to use. On top of that I was never informed that there is an entire upstairs part to the building. Upstairs hosts executive…

Grant, et al (1998) experimented with “40 participants who read a two-page article under silent or noisy conditions.” Participants were then tested with matching or mismatching conditions example; silent study/silent test and noisy study/noisy test or silent study/noisy test etc. The design of the test was to imitate standard classroom tests, and assess the participant’s ability to comprehend new material (i.e. memory for meaning). To accommodate the possibility that context-dependency effects…

The more the brain is encoding the information, the better possibility that it will be able to recall this information. Encoding has four main types to it; Acoustic, Visual, Tactile, and Semantic coding. In a way, we uses these four types of encoding to learn something new. This one of the errors in my experiment. I did not tell the subjects how they should study the words, I just gave them the words and told them to study them. “It is believed that, in general, encoding for short-term memory…